Projects

The current research projects at NRU are listed below. Many of the projects are carried out jointly with NRU's collaborators. The projects deal both with clinical and experimental investigation where the clinical projects represent the majority. The projects are performed at Rigshospitalet in the PET, SPECT and experimental laboratories, respectively. Some studies involve MR investigation which are performed at the Danish Research Center for Magnetic Resonance at Hvidovre Hospital, which is also part of Copenhagen University Hospital. For futher information about a specific project, please use the indicated contact.

PET and clinical studies    Data analysis studies    Experimental studies

PET and clinical studies

Main responsible: Gitte Moos Knudsen

The serotonergic system in patients with cognitive and emotional disturbances
Responsible: Steen Hasselbalch

Molecular imaging of the brain’s 5-HT4 serotonin receptor and amyloid load in healthy and Alzheimer patients and in patients at risk for depression
Responsible: Karine Madsen, Steen Hasselbalch

The serotonergic system in affective disorders
Responsible: Vibe Frøkjær

The serotonergic system in early Alzheimer’s disease
Responsible: Lisbeth Marner, Steen Hasselbalch

Characterization of the serotonergic transmittersystem and brain morphology in young adult MDMA abusers
Responsible: David Erritzøe

The serotonergic transmittersystem in obesity
Responsible: Mette Haahr

Data analysis studies

Main responsible: Claus Svarer

Neuroinformatics
Responsible: Finn Aarup Nielsen

Automatic definition of volumes of interest (VOI's)
Responsible: Claus Svarer

Experimental studies

Main responsible: Susana Aznar, Jens D. Mikkelsen and Gitte Moos Knudsen

BDNF and 5-HT2A receptor interaction: Role in depression and antidepressant treatment
Responsible: Anders Bue Klein

5-HT2A receptor ineraction with other receptor systems and its involvement in synaptic plasticity
Responsible:  Martin Santini

Relation between amyloid beta depositions and structure, receptor content and cognition in minipigs
Responsible: Birgitte Rahbek Kornum

The 5-HT2A receptor in Alzheimer animal models
Responsible: Susana Aznar

Characterization of the alpha-7 nicotinic receptor in cognition and schizophrenia
Responsible: Morten Skøtt Thomsen

Characterization of the 5-HT2A radiolabelled agonists and its effect on 5-HT2A receptors
Responsible: Mikael Palner

Validation of 5-HT2A agonist as new PET ligands in minipigs
Responsible: Anders Ettrup

Relation between serotonergic innervation and predisposition to depression
Responsible: Susana Aznar

Cerebral blood flow autoregulation in renal dysfunction
Responsible: Sigurd Sigurdsson and Olaf B. Paulson