Curriculum Vitae - Vibe Gedsø Frøkjær, MD, born 1972
Academic degrees: University exam in medicine in 2000. (MD, Cand. Med) from the University of Copenhagen, Denmark. PhD from the University of Copenhagen in 2008.
Pregraduate appointments
1991: Research trainee at Novo Nordisk. Working with devolopment of media for growth of genetically modified mammal cells.
1991-1997: Guide at exhibitions at ”Experimentarium”, Centre for Communication of Natural Sciences.
1997 and 1998: Locum doctor at Department of Endocrine- and Breast Surgery, Copenhagen University Hospital, Rigshospitalet. Participated in projects concerning primary hyperparathyroidism, also in collaboration with the center for Osteoporosis at Århus University Hospital. See publications.
Postgraduate appointments:
2000: 6 months appointment at the Department of Neurology, Copenhagen University Hospital, Rigshospitalet.
2000-2002: 18 month rotation in Frederiksborg Amt, consisting of 6 month general surgery, 6 month internal medicine and 6 month general practice.
2002: (Present appointment): From March 2002 appointed as a researcher at Neurobiology Research Unit (NRU), Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. In addition, managing the interpretation of SPECT brain perfusion scans in the clinical setting. Participating in the work of implementing and optimizing the IRIX scanner. Managing the project of creating a reference material of brain perfusion SPECT (Single Photon Computed Emission Tomography) scans in healthy volunteers with 99mTc-sHMPAO for the IRIX scanner.
2004-2007: Research: Working on the phd project: Relating cerebral serotonin 2A receptor and serotonin transporter binding to personality and familial risk for mood disorder. Funded for 3 years by Copenhagen University. Clinical work: Implementing methods for SISCOM – subtraction images based on inter-ictal and peri-ictal SPECT studies. Responsibe for the interpretation of SISCOM studies in candidates for epileptic surgery, primarily children.
2008: Working at center for integrated molecular imaging (cimbi), Neurobiology Research Unit, Copenhagen University Hospital in a post doc position writing up studies on the associations between gender and endogenous sex hormones, cortisol waking response and post and presynaptic markers of serotonergic neurotransmission measured in vivo.
Research areas:
1991: Basic research Novo Nordisk, mentioned above.
1999-2000: Project on Primary Hyperparathyroidism and renal calcium excretion. Project on Primary hyperparathyroidism and risk of fracture. The work is published in the articles mentioned belove.
2002: Brain perfusion in normal brains and normal aging. Methodological study in healthy volunteers of the serotonin transporter with a new SPECT-ligand, 123I-ADAM.
2004-2007: The serotonergic system in mood disorders and in relation to personality differences, gender differences, and differences in pain perception in healthy subjects.
Publications
Frokjaer VG, Vinberg M, Baare W, Erritzoe D, Baare W, Holst KK, Mortensen EL, Arfan H, Madsen J, Kessing LV, Knudsen GM. Frontolimbic serotonin 2A receptor binding, neuroticism, and familial risk for mood disorder (submitted).
Frokjaer VG, Vinberg M, Erritzoe D, Svarer C, Baare W, Madsen K, Madsen J, Kessing LV, Knudsen GM. High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding (submitted).
Frokjaer VG, Erritzoe D, Madsen J, Paulson OB, Knudsen GM. Cerebral cortical serotonin 2A receptor binding is unaffected by gender and hormonal contraception (submitted).
Frokjaer VG, Mortensen EL, Nielsen FAa, Haugbol S, Pinborg LH, Adams KH, Svarer C, Hasselbalch SG, Holm S, Paulson OB, Knudsen GM. Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder. (Biol Psychiatry 2007).
Frokjaer VG, Pinborg LH, Madsen J, Wagner Aa, Knudsen GM. Evaluation of the serotonin transporter ligand [123I]ADAM for SPECT studies in humans. J Nucl Med. 2008, 49(2):247-254.
Erritzoe D, Rasmussen H, Kristiansen KT, Frokjaer VG, Haugbol S, Baare W, Lublin H, Knudsen GM, Glenthoj BY. Serotonin 2A binding in neuroleptic-naive schizophrenic patients and healthy controls using PET and [18-F]altanserin (accepted Neurospycho-pharmacology 2007).
Haugbol S, Lars H. Pinborg, Vibe G. Frokjaer, David Erritzøe, Lisbeth Marner, Steen G. Hasselbalch, Claus Svarer, Lis Hasholt, Søren Holm, Olaf B. Paulson, Gitte M. Knudsen. Functional Variations in the Serotonin Transporter Gene Affects in vivo Brain Serotonin 2A Receptor Binding (submitted).
Pinborg LH, Arfan H, Haugbol S, Kirsten OK, Hjelmborg JVB, Svarer C, Frokjaer VG,
Paulson OB, Holm S, Knudsen GM. The 5-HT2A receptor binding pattern in the human brain is strongly genetically determined (accepted Neuroimage 2007).
Frokjaer VG, Strauss GI, Mehlsen J, Knudsen GM, Rasmussen V, Larsen FS. Autonomic dysfunction and impaired cerebral autoregulation in cirrhosis. Clin Auton Res. 2006; 16: 208-16.
Haugbol S, Pinborg LH, Arfan HM, Frokjaer VG, Madsen J, Dyrby TB, Svarer C, Knudsen GM. Reproducibility of 5-HT(2A) receptor measurements and sample size estimations with [(18)F]altanserin PET using a bolus/infusion approach. Eur J Nucl Med Mol Imaging. 2006, 34(6):910-5.
Svarer C. Madsen K, Hasselbalch SG, Pinborg LH, Haugbøl S, Frøkjær VG, Holm S, Paulson OB, Knudsen GM. MR-based Automatic Delineation of Volumes of Interest in Human Brain PET-images using Probability Maps. Neuroimage. 2005, 24: 969-79.
Pinborg LH, Ziebell M, Frokjaer VG, de Nijs R, Svarer C, Haugbol S, Yndgaard S, Knudsen GM. Quantification of 123I-PE2I binding to dopamine transporter with SPECT after bolus and bolus/infusion. J Nucl Med. 2005, 46:1119-27.
Adams KH, Pinborg LH, Svarer C, Hasselbalch SG, Holm S, Haugbol S, Madsen K, Frokjaer V, Martiny L, Paulson OB, Knudsen GM. A database of [18F]-altanserin binding to 5-HT2A receptors in normal volunteers: normative data and relationship to physiological, and demographic variables. Neuroimage. 2004, 21:1105-13.
Vestergaard P, Mollerup CL, Frokjaer VG, Christiansen P, Blichert-Toft M, Mosekilde L. Cardiovascular Events before and after Surgery for Primary Hyperparathyroidism. World Journal of Surgery 2003, 27: 216-222.
Frokjaer VG, Mollerup CL. Primary hyperparathyroidism: Renal calcium excretion in patients with and without renal stone disease before and after parathyroidectomy. World Journal of Surgery 2002, 26: 532-535.
Mollerup CL, Vestergaard P, Frokjaer VG, Mosekilde L, Christiansen P, Blichert-Toft M. Risk of renal stone events in primary hyperparathyroidism before and after parathyroid surgery: controlled retrospective follow up study. British Medical Journal 2002, 325: 807.
Vestergaard P, Mollerup CL, Frokjaer VG, Christiansen P, Blichert-Toft M, Mosekilde L. Cohort study of risk of fracture before and after surgery for primary hyperparathyroidism. British Medical Journal 2000, 321: 598-602.
Manuscripts in preparation
Kupers R, Frokjaer VG, Naert A, Erritzoe D, Kehlet H, Knudsen GM. A PET [18F]altanserin study of 5-HT 2A receptor binding in the human brain and responses to painful heat.
Erritzoe D, Frokjaer VG, Arfan H, Haugbol S, Pinborg L, Svarer C, Madsen J, Paulson OB, Knudsen GM. Overweight associated with increased cortical 5-HT2A receptor binding in humans.
Erritzoe D, Frokjaer VG, Arfan H, Svarer C, Madsen J, Paulson OB, Knudsen GM. Comparison of presynaptic SERT and postsynaptic 5-HT2A receptor binding levels humans using PET.