Neuropharmacological treatment: Precision medicine in epilepsy and

Project start: July 1st, 2019
Project end:
June 30th, 2024
40 mio DKK from Lundbeck Foundation
Prof. Gitte Moos Knudsen, NRU

A 2-min video pitch of the project can be found here.
An interview about the project with Gitte on DR P1 Morgen is available here.

The aim
of this thematic alliance is to establish which key features predict drug response in patients with epilepsy or depression.

There is currently an enormous unmet need for the development of effective precision medicine approaches for brain disorders. More precise treatment strategies are needed to replace the present “one-size-fits-all” and subsequent “trial-and-error” approach currently  applied in our patients. An important step to achieve this goal is to uncover endophenotypes and biomarkers that can critically help to stratify patient cohorts (see figure below).

To enable stratification of patients based on their underlying pathogenetic and pathophysiological brain disturbances will provide “enriched” patient populations that are more likely to benefit from specific interventions. Stratification will also be enormously beneficial for interpretation of clinical trials that aim to test new compounds and is essential to allow for an optimised treatment of patients with brain disorders. Another important challenge is to determine the target engagement of pharmacological interventions, and to predict occupancy based on, e.g., plasma drug concentrations.

With BrainDrugs, we will focus on two frequent and devastating brain disorders: epilepsy and major depression (MDD). We have chosen to study epilepsy and MDD because they are frequent and devastating brain disorders with significant comorbidity and because both conditions are treated with pharmacological interventions that often fail to succeed, including failure due to intolerable adverse effects. Epilepsy often co-occurs with mood disorders and there is reason to believe that the comorbidity is underrecognized in both patient groups. Comorbidity is also associated with less favorable outcome of drug treatment. That is, there is a huge unmet medical need to better diagnose and treat these two serious brain disorders.

Initially, we aim at understanding the mechanisms which explain the variation in drug response using a diverse set of methodologies, including standard epidemiological biostatistical approaches with national registry data and machine learning based on big data from routine care, e.g., clinical (symptom) characterization, neuroimaging, or genetics. The discovery phase will likely identify features of drug resistance, which will be used to characterize groups of patients and identify clusters of factors associated with comparable types of drug responses. From this, we will formulate a series of drug response indices that when validated, can be used to personalise drug interventions and to establish a recommendation for treatment of the individual patient.

Methods and Materials:
We will make use of Danish registries to identify associations between intake of brain targeting drugs and clinical outcomes in order to uncover which patient features define a successful antidepressive or antiepileptic drug treatment. To investigate if we can identify patient subgroups, we will conduct advanced text-mining analyses which extract specific clinical features from electronic patient records. Through existing deep phenotyping or genetic databases with biobanks, those features will be related to, e.g., genetic and neuroimaging data to define biologically valid patient subgroups suffering from depression and epilepsy. To increase power to detect biomarkers and treatment response, we will establish new cohorts of patients with epilepsy and depression that we follow longitudinally.

BrainDrugs will consist of seven coherent work packages, as depicted in the figure below.

Expected outcome and perspectives:
It is our ambition to set the stage for a precision medicine approach in pharmacological treatment of epilepsy and depression, for the benefit of future patients. To succeed in our mission, we have devised a strategy for implementation of research outcomes in the clinic. It is our hope that in the long run, BrainDrugs can serve as a model to be implemented internationally, and for other brain disorders.

Project management:
The organization of BrainDrugs is depicted in the organogram below.

The Executive Board (EB) consists of seven senior scientists that will oversee and review the progress of the work and make all relevant strategic decisions. The EB will gather physically at least once yearly, at the annual meeting, and will have audiovisual conferences in-between. The board is composed to broadly ensure coverage of most of the disciplines exerted in BrainDrugs:

- Gitte Moos Knudsen, MD, DMSc. PI of BrainDrugs. Chairperson at NRU, Rigshospitalet. Neurologist with research focus on translational neurobiology and neuropharmacology. Director of The Innovation Fund Denmark funded Center for Experimental Medicine Neuropharmacology ( and president-elect for the European College of Neuropharmacology (ECNP). Professor Knudsen will be overall responsible for BrainDrugs, including the financial and reporting responsibility, and she will be assisted by administrative staff to cover daily administration as well as financial and legal aspects of BrainDrugs.

- Søren Brunak, PhD. Professor of Disease Systems Biology at the University of Copenhagen and professor of Bioinformatics at the Technical University of Denmark. He has expertise within bioinformatics, systems biology and medical informatics.

- Ida Hageman, MD, DMSc. Assistant Director at Mental Health Services, Capital Region of Denmark. Her scientific interest is in major depression and in translational research and clinical research into affective disorders.

- Vibe G. Frøkjær, MD, PhD. Psychiatrist, Psychiatric Center Copenhagen and Neurobiology Research Unit, Rigshsopitalet. Her scientific interest is the influence hormonal changes on mental health, major depression and in translational research and clinical research into affective disorders.

- Lars H. Pinborg, MD, DMSc. Lundbeck Foundation associate professor in precision medicine, University of Copenhagen. He is in charge of the Epilepsy Clinic at RH and his scientific focus area includes clinical epileptology, molecular and structural neuroimaging, drug resistance in epilepsy, and epilepsy surgery.

- Thomas Werge, PhD. Professor at Department of Clinical Medicine, University of Copenhagen and Director of Institute of Biological Psychiatry, Mental Health Services, Capital Region of Denmark. He has expertise within precision psychiatry, neurogenetics, translational psychiatry, and translational genomics.

- Leif Østergaard, MD, DMSc. Professor at Department of Neuroradiology at Aarhus University and Director of Center of Functionally Integrated Neuroscience (CFIN) and MINDLab, Aarhus University. His main research area is neuroimaging in humans and it involves modeling and development of methods.

Project members:
The BrainDrugs alliance builds on strong cross-disciplinary research environments within universities and hospitals in Denmark and is supported by two European partners from Lausanne University Hospital (CHUV), Switzerland and VU University Medical Center (VUMC) in Amsterdam, Netherlands. The involved Danish institutions span several different departments at Copenhagen University Hospital, Rigshospitalet (RH), University of Copenhagen (UCPH), Aarhus University Hospital (AUH), and Aarhus University (AU), as well as the Filadelfia Epilepsy Hospital (Filadelfia) and three different mental health centers from the Capital Region of Denmark, namely Psychiatric Center Copenhagen, Psychiatric Center Glostrup, and Mental Health Center Sct. Hans.  The research team is composed of the following list of highly experienced clinical and academic partners:

Prof. Gitte Moos Knudsen - Neurobiology Research Unit, RH & SUND-UCPH

Bioinformatics and Statistics:
Prof. Søren Brunak - NNF Center for Protein Research, SUND-UCPH
Associate Prof. Esben Budtz-Jørgensen - Section of Biostatistics, SUND-UCPH

Clinical Psychiatry:

Head of Department Ida Hageman - Psychiatric Center Copenhagen, RH & SUND-UCPH
Prof. Martin Balslev Jørgensen - Psychiatric Center Copenhagen, RH & SUND-UCPH
Prof. Lars Kessing - Psychiatric Center Copenhagen, RH & SUND-UCPH
Prof. Kamilla Miskowiak - Psychiatric Center Copenhagen, RH & Dept of Psychology, UCPH
Prof. Poul Videbech - Mental Health Centre Glostrup & SUND-UCPH

Clinical Neurology:

Associate Prof. Jakob Christensen - Dept Neurology, AUH & Dept Clinical Medicine, AU
Head of Department Jesper Erdal - Dept Neurology, RH
Prof. Olaf Paulson - Neurobiology Research Unit, RH & SUND-UCPH
Associate Prof. Lars Pinborg - Neurobiology Research Unit & Dept of Neurology, RH & SUND-UCPH
Prof. Guido Rubboli - Filadelfia Epilepsy Hospital & SUND-UCPH
Prof. Philippe Ryvlin - CHUV, Lausanne, Switzerland & SUND-UCPH
Prof. Anne Sabers - Dept of Neurology, RH & SUND-UCPH


Prof. Brenda Penninx - Dept Psychiatry, VU University Medical Center in Amsterdam, Netherlands

Text mining:

Prof. Anders Søgaard - Dept Computer Science, UCPH

Neuroimaging Analysis:

Assistant Prof. Melanie Ganz - Neurobiology Research Unit, RH & Dept Computer Science, UCPH
Senior researcher Vibe Frøkjær, Neurobiology Research Unit & Psychiatric Center Copenhagen, RH
Prof. Leif Østergaard, Dept Neuroradiology, AUH & Dept Neuroradiology, AU


Prof. Thomas Werge, Dept Clinical Biochemistry, Mental Health Centre Sct. Hans & SUND-UCPH.

The currently ongoing PhD projects at NRU are listed below.

Student Project Supervisors Date of Enrollment Deadline
Camilla Borgsted Larsen Structural and functional brain signatures of sex-hormone transitions and implications for perinatal mental health

Vibe Gedsø Frøkjær
Gitte Moos Knudsen
Anja Pinborg

01.05.2018 30.04.2021
Agata Casado Sainz Dopamine dynamics and neuroenergetics in fronto-striatal circuit modulation Gitte Moos Knudsen
Rune Berg
Mikael Palner
Leslie Sombers
01.02.2019 28.03.2023
Nakul Raval In vivo PET imaging of α-Synuclein aggregates in pig brain Gitte Moos Knudsen
Mikael Palner
Stina Syvänen
01.03.2019 28.02.2022
Sophia Armand Serotonins rolle i tænkning, følelser og hjernefunktion i raske personer og i personer med kompulsiv adfærd Dea S. Stenbæk
Gitte Moos Knudsen
Barbara Sahakian
01.10.2019 30.09.2022
Annette Johansen Molecular neuroimaging of synaptic plasticity in the human brain Gitte Moos Knudsen
Patrick M Fisher
01.11.2019 26.11.2022
Stinne Høgh Maternal Mental Health Study (MAMA). Prevention of perinatal depression in high-risk group: effects and mothers' expectations

Vibe G. Frøkjær
Hanne K. Hegaard
Kristina M. Renault
Mette N. Svendsen
Laura E. Navne

11.05.2020 10.05.2023
Anine Persson Skibsted Functional MRI for the detection of covert consciousness and prognostication in patients with acute brain injury: A sub-study to CONNECT-ME (CONsciousness in NEurocritical Care cohorT study using fMRI and EEG)

Daniel Kondziella
Patrick Fisher
Gitte Moos Knudsen

01.08.2020 31.07.2023
Gjertrud Louise Laurell Development of novel methods for quantification of drug interactions in the living human brain

Gitte Moos Knudsen
R. Todd Ogden
Martin Schain

01.11.2020 31.10.2023
Søren Vinther Larsen Hormonal sensitivity and brain function: Do oral contraceptives distort serotonergic brain signaling and is it restored after discontinuation?

Vibe G. Frøkjær
Øjvind Lidegaard

16.11.2020 15.11.2023
Kristian Høj Reveles Jensen Brain neuroplasticity in major depressive disorder in response to treatment

Martin Balslev Jørgensen
Gitte Moos Knudsen
Vibeke Dam
Merete Osler
Anders Jørgensen

03.01.2021 02.01.2024
Sara Marie Ulv Larsen Ultra-fast MR neuroimaging: Effects of sleep, adrenergic inhibition and increased intracranial pressure

Gitte Moos Knudsen
Sebastian C Holst

01.02.2021 31.01.2024

Along with NRU's full time and part time staff, a number of visiting researchers, PhD students and students are involved in the research and clinical work at NRU.

The different staff categories are listed in the expanded Staff menu to the left. Simply use the last item "Find who?" if you are looking for a particular NRU employee but do not know to which category he/she belongs.

For any further information call (+45) 3545 6712 or send an email to .

Annual Reports:

All annual reports from NRU can be downloaded from here.

PhD theses:

All NRU PhD theses since 2005 are available for download here. Older theses are only available in printed form and upon request.

Doctoral dissertations:

  • Marner L. Communication among neurons. Quantitative measures in aging and disease. Defended Sep 16, 2011.
  • Pinborg LH. Molecular imaging of receptors and transporters in humans using PET and SPECT: from models to methods and potentials to pitfalls. Defended Jun 4, 2009.
  • Gerlach C. Disputats: Visual object recognition and category-specificity. Defended Nov 7, 2008.
  • Law I. Human brain mapping under increasing cognitive complexity using regional cerebral blood flow measurements and positron emission tomography. Defended Aug 31, 2007.
  • Møller K. Cerebral blood flow and metabolism in adults with acute bacterial meningitis. Defended Aug 24, 2007.
  • Strauss GI. The effect of hyperventilation upon cerebral blood flow and metabolism in patients with fulminant hepatic failure. Defended Mar 30, 2007.
  • Hasselbalch SG. Quantitation of brain metabolism in humans using PET-FDG: levels and limitations. Defended Apr 25, 2003.
  • Videbæk C. Single photon emission tomography for neuroreceptor studies: Methodological considerations. Defended in 2002.
  • Larsen FS. Cerebral circulation in liver failure: Ohm's law in force. Semin Liver Dis 1996;16:281-92. Defended in 1998.
  • Olsen KS. The influence of ketanserin on cerebral hemodynamics - with special reference to neuroanesthesia. Defended in 1997.
  • Waldemar G. Functional brain imaging with SPECT in normal aging and dementia. Methodological, pathophysiological, and diagnostic aspects. Cerebrovasc Brain Metab Rev 1995;7:89-130. Defended in 1996.
  • Knudsen GM. Application of the double-indicator technique for measurement of blood-brain barrier permeability in humans.Cerebrovasc Brain Metab Rev. 1994 Spring;6(1):1-30. Defended in 1994.

Peer-reviewed journal articles and books:


Original publications in peer-reviewed journals (34)
  • Alwassil OI, Khatri S, Schulte MK, Aripaka SS, Mikkelsen JD, Dukat M. N1H- and N1-Substituted Phenylguanidines as α7 Nicotinic Acetylcholine (nACh) Receptor Antagonists: Structure-Activity Relationship Studies. ACS Chem Neurosci. 2021 Jun 16;12(12):2194-2201
  • Bjertrup AJ, Jensen MB, Schjødt MS, Parsons CE, Kjærbye-Thygesen A, Mikkelsen RL, Moszkowicz M, Frøkjær VG, Vinberg M, Kessing LV, Væver MS, Miskowiak KW. Cognitive processing of infant stimuli in pregnant women with and without affective disorders and the association to postpartum depression. Eur Neuropsychopharmacol. 2021 Jan;42:97-109
  • Brandt IM, Köhler-Forsberg K, Ganz M, Ozenne B, Jorgensen MB, Poulsen A, Knudsen GM, Frokjaer VG, Fisher PM. Reward processing in major depressive disorder and prediction of treatment response - Neuropharm study. Eur Neuropsychopharmacol. 2021 Mar;44:23-33
  • Breusova K, Ernstsen KG, Palner M, Linnet K, Kristensen JL, Kretschmann AC. A quantitative method for the selective 5-HT2A agonist 25CN-NBOH in rat plasma and brain. J Pharm Biomed Anal. 2021 May 30;199:114016
  • Broberg L, Tabor A, Rosthøj S, Backhausen M, Frokjaer VG, Damm P, Hegaard HK. Effect of supervised group exercise on psychological well-being among pregnant women with or at high risk of depression (the EWE Study): A randomized controlled trial. Acta Obstet Gynecol Scand. 2021 Jan;100(1):129-138
  • Cantagallo E, De Backer M, Kicinski M, Ozenne B, Collette L, Legrand C, Buyse M, Péron J. A new measure of treatment effect in clinical trials involving competing risks based on generalized pairwise comparisons. Biom J. 2021 Feb;63(2):272-288
  • Christensen CE, Younis S, Lindberg U, de Koning P, Tolnai D, Paulson OB, Larsson HBW, Amin FM, Ashina M. Intradural artery dilation during experimentally induced migraine attacks. Pain. 2021 Jan;162(1):176-183
  • Dam VH, Hjordt LV, da Cunha-Bang S, Sestoft D, Knudsen GM, Stenbaek DS. Trait aggression is associated with five-factor personality traits in males. Brain Behav. 2021 Jul;11(7):e02175
  • Donovan LL, Johansen JV, Ros NF, Jaberi E, Linnet K, Johansen SS, Ozenne B, Issazadeh-Navikas S, Hansen HD, Knudsen GM. Effects of a single dose of psilocybin on behaviour, brain 5-HT2A receptor occupancy and gene expression in the pig. Eur Neuropsychopharmacol. 2021 Jan;42:1-11
  • Faurholt-Jepsen M, Frøkjær VG, Nasser A, Jørgensen NR, Kessing LV, Vinberg M. Associations between the cortisol awakening response and patient-evaluated stress and mood instability in patients with bipolar disorder: an exploratory study. Int J Bipolar Disord. 2021 Mar 1;9(1):8
  • Freiburghaus T, Svensson JE, Matheson GJ, Plavén-Sigray P, Lundberg J, Farde L, Cervenka S. Low convergent validity of [11C]raclopride binding in extrastriatal brain regions: A PET study of within-subject correlations with [11C]FLB 457. Neuroimage. 2021 Feb 1;226:117523
  • Ganz M, Nørgaard M, Beliveau V, Svarer C, Knudsen GM, Greve DN. False positive rates in positron emission tomography (PET) voxelwise analyses. J Cereb Blood Flow Metab. 2021 Jul;41(7):1647-1657
  • Giai J, Maucort-Boulch D, Ozenne B, Chiêm JC, Buyse M, Péron J. Net benefit in the presence of correlated prioritized outcomes using generalized pairwise comparisons: A simulation study. Stat Med. 2021 Feb 10;40(3):553-565
  • Ip CT, Olbrich S, Ganz M, Ozenne B, Köhler-Forsberg K, Dam VH, Beniczky S, Jørgensen MB, Frokjaer VG, Søgaard B, Christensen SR, Knudsen GM. Pretreatment qEEG biomarkers for predicting pharmacological treatment outcome in major depressive disorder: Independent validation from the NeuroPharm study. Eur Neuropsychopharmacol. 2021 Aug;49:101-112
  • Ip CT, Olbrich S, Ganz M, Ozenne B, Köhler-Forsberg K, Dam VH, Beniczky S, Jørgensen MB, Frokjaer VG, Søgaard B, Christensen SR, Knudsen GM. Pretreatment qEEG biomarkers for predicting pharmacological treatment outcome in major depressive disorder: Independent validation from the NeuroPharm study. Eur Neuropsychopharmacol. 2021 Aug;49:101-112
  • Jørgensen LM, Henriksen T, Mardosiene S, Keller SH, Stenbæk DS, Hansen HD, Jespersen B, Thomsen C, Weikop P, Svarer C, Knudsen GM. Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study. J Cereb Blood Flow Metab. 2021 Aug;41(8):1954-1963
  • Kaltsouni E, Fisher PM, Dubol M, Hustad S, Lanzenberger R, Frokjaer VG, Wikström J, Comasco E, Sundström-Poromaa I. Brain reactivity during aggressive response in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator. Neuropsychopharmacology. 2021 Jul;46(8):1460-1467
  • Laurell GL, Plavén-Sigray P, Jucaite A, Varrone A, Cosgrove KP, Svarer C, Knudsen GM; Karolinska Schizophrenia Project Consortium, Ogden RT, Zanderigo F, Cervenka S, Hillmer AT, Schain M. Nondisplaceable Binding Is a Potential Confounding Factor in 11C-PBR28 Translocator Protein PET Studies. J Nucl Med. 2021 Mar;62(3):412-417
  • Lee CJ, Toft-Petersen AP, Ozenne B, Phelps M, Olesen JB, Ellinor PT, Gislason G, Lip GYH, Torp-Pedersen C, Gerds TA. Assessing absolute stroke risk in patients with atrial fibrillation using a risk factor-based approach. Eur Heart J Cardiovasc Pharmacother. 2021 Apr 9;7(FI1):f3-f10
  • Lee M, Fatouros-Bergman H, Plavén-Sigray P, Ikonen Victorsson P, Sellgren CM, Erhardt S, Flyckt L, Farde L, Cervenka S. No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis. NPJ Schizophr. 2021 Sep 21;7(1):46
  • Madsen MK, Stenbæk DS, Arvidsson A, Armand S, Marstrand-Joergensen MR, Johansen SS, Linnet K, Ozenne B, Knudsen GM, Fisher PM. Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience. Eur Neuropsychopharmacol. 2021 Sep;50:121-132
  • Madsen MK, Knudsen GM. Plasma psilocin critically determines behavioral and neurobiological effects of psilocybin. Neuropsychopharmacology. 2021 Jan;46(1):257-258
  • Mariegaard J, Wenstrup J, Lim KZM, Bidstrup PE, von Heymann A, Johansen C, Knudsen GM, Law I, Specht L, Stenbæk DS. Prevalence of cognitive impairment and its relation to mental health in Danish lymphoma survivors. Support Care Cancer. 2021 Jun;29(6):3319-3328
  • Mehta D, Grewen K, Pearson B, Wani S, Wallace L, Henders AK, Binder EB, Frokjaer VG, Meltzer-Brody S, Wray NR, Stuebe AM. Genome-wide gene expression changes in postpartum depression point towards an altered immune landscape. Transl Psychiatry. 2021 Mar 4;11(1):155
  • Nørgaard M, Beliveau V, Ganz M, Svarer C, Pinborg LH, Keller SH, Jensen PS, Greve DN, Knudsen GM. A high-resolution in vivo atlas of the human brain's benzodiazepine binding site of GABAA receptors. Neuroimage. 2021 May 15;232:117878
  • Opel N, Narr KL, Abbott C, Argyelan M, Espinoza R, Emsell L, Bouckaert F, Sienaert P, Vandenbulcke M, Nordanskog P, Repple J, Kavakbasi E, Jorgensen MB, Paulson OB, Hanson LG, Dols A, van Exel E, Oudega ML, Takamiya A, Kishimoto T, Ousdal OT, Haavik J, Hammar Å, Oedegaard KJ, Kessler U, Bartsch H, Dale AM, Baune BT, Dannlowski U, Oltedal L, Redlich R. Elevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy. J Psychiatry Neurosci. 2021 Jul 5;46(4):E418-E426
  • Opheim G, van der Kolk A, Markenroth Bloch K, Colon AJ, Davis KA, Henry TR, Jansen JFA, Jones SE, Pan JW, Rössler K, Stein JM, Strandberg MC, Trattnig S, Van de Moortele PF, Vargas MI, Wang I, Bartolomei F, Bernasconi N, Bernasconi A, Bernhardt B, Björkman-Burtscher I, Cosottini M, Das SR, Hertz-Pannier L, Inati S, Jurkiewicz MT, Khan AR, Liang S, Ma RE, Mukundan S, Pardoe H, Pinborg LH, Polimeni JR, Ranjeva JP, Steijvers E, Stufflebeam S, Veersema TJ, Vignaud A, Voets N, Vulliemoz S, Wiggins CJ, Xue R, Guerrini R, Guye M. 7T Epilepsy Task Force Consensus Recommendations on the Use of 7T MRI in Clinical Practice. Neurology. 2021 Feb 16;96(7):327-341
  • Ott CV, Macoveanu J, Bowie CR, Fisher PM, Knudsen GM, Kessing LV, Miskowiak KW. Change in prefrontal activity and executive functions after action-based cognitive remediation in bipolar disorder: a randomized controlled trial. Neuropsychopharmacology. 2021 May;46(6):1113-1121
  • Plavén-Sigray P, Matheson GJ, Coughlin JM, Hafizi S, Laurikainen H, Ottoy J, De Picker L, Rusjan P, Hietala J, Howes OD, Mizrahi R, Morrens M, Pomper MG, Cervenka S. Meta-analysis of the Glial Marker TSPO in Psychosis Revisited: Reconciling Inconclusive Findings of Patient-Control Differences. Biol Psychiatry. 2021 Feb 1;89(3):e5-e8
  • Raval NR, Johansen A, Donovan LL, Ros NF, Ozenne B, Hansen HD, Knudsen GM. A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain. Int J Mol Sci. 2021 Jan 15;22(2):E835
  • Stenbæk DS, Madsen MK, Ozenne B, Kristiansen S, Burmester D, Erritzoe D, Knudsen GM, Fisher PM. Brain serotonin 2A receptor binding predicts subjective temporal and mystical effects of psilocybin in healthy humans. J Psychopharmacol. 2021 Apr;35(4):459-468
  • Svensson JE, Svanborg C, Plavén-Sigray P, Kaldo V, Halldin C, Schain M, Lundberg J. Serotonin transporter availability increases in patients recovering from a depressive episode. Transl Psychiatry. 2021 May 10;11(1):264
  • Younis S, Christensen CE, Vestergaard MB, Lindberg U, Tolnai D, Paulson OB, Larsson HB, Hougaard A, Ashina M. Glutamate levels and perfusion in pons during migraine attacks: A 3T MRI study using proton spectroscopy and arterial spin labeling. J Cereb Blood Flow Metab. 2021 Mar;41(3):604-616
  • Wagner MK, Berg SK, Tang LH, Stenbaek DS, Hassager C, Missel M. Understanding the lived experiences of short- and long-term consequences on daily life after out-of-hospital cardiac arrest. A focus group study. J Adv Nurs. 2021 Mar;77(3):1442-1452

Books and book chapters
  • Gade A, Knudsen GM. Metaboliske, endokrine og andre systemiske sygdomme. In: Gade A, Gerlach C, Starrfelt R, Pedersen PM (eds). Klinisk neuropsykologi. 2. udgave. København: Frydenlund Academic, 2021:379-390
  • Knudsen G.M., Hasselbalch S.G. (2021) Imaging of the Serotonin System: Radiotracers and Applications in Memory Disorders. In: Dierckx R.A., Otte A., de Vries E.F., van Waarde A., Lammertsma A.A. (eds) PET and SPECT of Neurobiological Systems. Springer, Cham.

Multicenter studies without co-authorship

  • Gau R, Noble S, Heuer K, Bottenhorn KL, Bilgin IP, Yang YF, Huntenburg JM, Bayer JMM, Bethlehem RAI, Rhoads SA, Vogelbacher C, Borghesani V, Levitis E, Wang HT, Van Den Bossche S, Kobeleva X, Legarreta JH, Guay S, Atay SM, Varoquaux GP, Huijser DC, Sandström MS, Herholz P, Nastase SA, Badhwar A, Dumas G, Schwab S, Moia S, Dayan M, Bassil Y, Brooks PP, Mancini M, Shine JM, O'Connor D, Xie X, Poggiali D, Friedrich P, Heinsfeld AS, Riedl L, Toro R, Caballero-Gaudes C, Eklund A, Garner KG, Nolan CR, Demeter DV, Barrios FA, Merchant JS, McDevitt EA, Oostenveld R, Craddock RC, Rokem A, Doyle A, Ghosh SS, Nikolaidis A, Stanley OW, Uruñuela E; Brainhack Community. Brainhack: Developing a culture of open, inclusive, community-driven neuroscience. Neuron. 2021 Jun 2;109(11):1769-1775


Original publications in peer-reviewed journals (46)
  • Andersen HG, Raghava JM, Svarer C, Wulff S, Johansen LB, Antonsen PK, Nielsen MØ, Rostrup E, Vernon AC, Jensen LT, Pinborg LH, Glenthøj BY, Ebdrup BH. Striatal Volume Increase After Six Weeks of Selective Dopamine D2/3 Receptor Blockade in First-Episode, Antipsychotic-Naïve Schizophrenia Patients. Front Neurosci. 2020 May 20;14:484
  • Andersen JV, Jakobsen E, Westi EW, Lie MEK, Voss CM, Aldana BI, Schousboe A, Wellendorph P, Bak LK, Pinborg LH, Waagepetersen HS. Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex. Glia. 2020 Dec;68(12):2601-2612
  • Baltzersen OB, Meltzer HY, Frokjaer VG, Raghava JM, Baandrup L, Fagerlund B, Larsson HBW, Fibiger HC, Glenthøj BY, Knudsen GM, Ebdrup BH. Identification of a Serotonin 2A Receptor Subtype of Schizophrenia Spectrum Disorders With Pimavanserin: The Sub-Sero Proof-of-Concept Trial Protocol. Front Pharmacol. 2020 Apr 30;11:591
  • Beliveau V, Ozenne B, Strother S, Greve DN, Svarer C, Knudsen GM, Ganz M. The structure of the serotonin system: A PET imaging study. Neuroimage. 2020 Jan 15;205:116240
  • Bratteby K, Torkelsson E, L'Estrade ET, Peterson K, Shalgunov V, Xiong M, Leffler H, Zetterberg FR, Olsson TG, Gillings N, Nilsson UJ, Herth MM, Erlandsson M. In Vivo Veritas: 18F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors. J Med Chem. 2020 Jan 23;63(2):747-755
  • Donat CK, Hansen HH, Hansen HD, Mease RC, Horti AG, Pomper MG, L'Estrade ET, Herth MM, Peters D, Knudsen GM, Mikkelsen JD. In Vitro and In Vivo Characterization of Dibenzothiophene Derivatives [125I]Iodo-ASEM and [18F]ASEM as Radiotracers of Homo- and Heteromeric α7 Nicotinic Acetylcholine Receptors. Molecules. 2020 Mar 20;25(6)
  • Donovan LL, Magnussen JH, Dyssegaard A, Lehel S, Hooker JM, Knudsen GM, Hansen HD. Imaging HDACs In Vivo: Cross-Validation of the [11C]Martinostat Radioligand in the Pig Brain. Mol Imaging Biol. 2020 Jun;22(3):569-577
  • Erritzoe D, Ashok AH, Searle GE, Colasanti A, Turton S, Lewis Y, Huiban M, Moz S, Passchier J, Saleem A, Beaver J, Lingford-Hughes A, Nutt DJ, Howes OD, Gunn RN, Knudsen GM, Rabiner EA. Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge. Neuropsychopharmacology. 2020 Apr;45(5):804-810
  • Foged MT, Martens T, Pinborg LH, Hamrouni N, Litman M, Rubboli G, Leffers AM, Ryvlin P, Jespersen B, Paulson OB, Fabricius M, Beniczky S. Diagnostic added value of electrical source imaging in presurgical evaluation of patients with epilepsy: A prospective study. Clin Neurophysiol. 2020 Jan;131(1):324-329
  • Frokjaer VG. Pharmacological sex hormone manipulation as a risk model for depression. J Neurosci Res. 2020 Jul;98(7):1283-1292
  • Hansen HD, Lindberg U, Ozenne B, Fisher PM, Johansen A, Svarer C, Keller SH, Hansen AE, Knudsen GM. Visual stimuli induce serotonin release in occipital cortex: A simultaneous positron emission tomography/magnetic resonance imaging study. Hum Brain Mapp. 2020 Aug 19;41(16):4753-4763
  • Hjordt LV, Ozenne B, Armand S, Dam VH, Jensen CG, Köhler-Forsberg K, Knudsen GM, Stenbæk DS. Psychometric Properties of the Verbal Affective Memory Test-26 and Evaluation of Affective Biases in Major Depressive Disorder. Front Psychol. 2020 Jun 5;11:961
  • Holst KK, Budtz-Jørgensen E. A two-stage estimation procedure for non-linear structural equation models. Biostatistics. 2020 Oct 1;21(4):676-691
  • Jensen ME, Galli A, Thomsen M, Jensen KL, Thomsen GK, Klausen MK, Vilsbøll T, Christensen MB, Holst JJ, Owens A, Robertson S, Daws L, Zanella D, Gether U, Knudsen GM, Fink-Jensen A. Glucagon-like peptide-1 Receptor Regulation of Basal Dopamine Transporter Activity Is Species-Dependent. Neurochem Int. 2020 Sep;138:104772
  • Knudsen GM, Ganz M, Appelhoff S, Boellaard R, Bormans G, Carson RE, Catana C, Doudet D, Gee AD, Greve DN, Gunn RN, Halldin C, Herscovitch P, Huang H, Keller SH, Lammertsma AA, Lanzenberger R, Liow JS, Lohith TG, Lubberink M, Lyoo CH, Mann JJ, Matheson GJ, Nichols TE, Nørgaard M, Ogden T, Parsey R, Pike VW, Price J, Rizzo G, Rosa-Neto P, Schain M, Scott PJ, Searle G, Slifstein M, Suhara T, Talbot PS, Thomas A, Veronese M, Wong DF, Yaqub M, Zanderigo F, Zoghbi S, Innis RB. Guidelines for the content and format of PET brain data in publications and archives: A consensus paper. J Cereb Blood Flow Metab. 2020 Aug;40(8):1576-1585
  • Kringelbach ML, Cruzat J, Cabral J, Knudsen GM, Carhart-Harris R, Whybrow PC, Logothetis NK, Deco G. Dynamic coupling of whole-brain neuronal and neurotransmitter systems. Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9566-9576
  • Kramer V, Dyssegaard A, Flores J, Soza-Ried C, Rösch F, Knudsen GM, Amaral H, Herth MM. Characterization of the serotonin 2A receptor selective PET tracer (R)-[18F]MH.MZ in the human brain. Eur J Nucl Med Mol Imaging. 2020 Feb;47(2):355-365
  • Krarup S, Mertz C, Jakobsen E, Lindholm SEH, Pinborg LH, Bak LK. Distinct effects on cAMP signaling of carbamazepine and its structural derivatives do not correlate with their clinical efficacy in epilepsy. Eur J Pharmacol. 2020 Nov 5;886:173413
  • Köhler-Forsberg K, Jorgensen A, Dam VH, Stenbæk DS, Fisher PM, Ip CT, Ganz M, Poulsen HE, Giraldi A, Ozenne B, Jørgensen MB, Knudsen GM, Frokjaer VG. Predicting Treatment Outcome in Major Depressive Disorder Using Serotonin 4 Receptor PET Brain Imaging, Functional MRI, Cognitive-, EEG-Based, and Peripheral Biomarkers: A NeuroPharm Open Label Clinical Trial Protocol. Front Psychiatry. 2020 Jul 23;11:641
  • Larsen SV, Köhler-Forsberg K, Dam VH, Poulsen AS, Svarer C, Jensen PS, Knudsen GM, Fisher PM, Ozenne B, Frokjaer VG. Oral contraceptives and the serotonin 4 receptor: a molecular brain imaging study in healthy women. Acta Psychiatr Scand. 2020 Oct;142(4):294-306
  • Licht CL, Mortensen EL, Hjordt LV, Stenbaek DS, Arentzen TE, Nørremølle A, Knudsen GM. Serotonin transporter gene (SLC6A4) variation and sensory processing sensitivity-Comparison with other anxiety-related temperamental dimensions. Mol Genet Genomic Med. 2020 Aug;8(8):e1352
  • Lind A, Boraxbekk CJ, Petersen ET, Paulson OB, Siebner HR, Marsman A. Regional Myo-Inositol, Creatine, and Choline Levels Are Higher at Older Age and Scale Negatively with Visuospatial Working Memory: A Cross-Sectional Proton MR Spectroscopy Study at 7 Tesla on Normal Cognitive Ageing. J Neurosci. 2020 Oct 14;40(42):8149-8159
  • L 'Estrade ET, Shalgunov V, Edgar FG, Strebl-Bantillo MG, Xiong M, Crestey F, Neelamegam R, Dyssegaard A, Lehel S, Erlandsson M, Ohlsson T, Hooker JM, Knudsen GM, Herth MM, Hansen HD. Radiosynthesis and preclinical evaluation of [11 C]Cimbi-701 - Towards the imaging of cerebral 5-HT7 receptors. J Labelled Comp Radiopharm. 2020 Feb;63(2):46-55
  • L'Estrade ET, Erlandsson M, Edgar FG, Ohlsson T, Knudsen GM, Herth MM. Towards selective CNS PET Imaging of the 5-HT7 Receptor System: Past, Present and Future. Neuropharmacology. 2020 Aug 1;172:107830
  • Macoveanu J, Kjaerstad HL, Chase HW, Frangou S, Knudsen GM, Vinberg M, Kessing LV, Miskowiak KW. Abnormal prefrontal cortex processing of reward prediction errors in recently diagnosed patients with bipolar disorder and their unaffected relatives. Bipolar Disord. 2020 Dec;22(8):849-859
  • Madsen MK, Fisher PM, Stenbæk DS, Kristiansen S, Burmester D, Lehel S, Páleníček T, Kuchař M, Svarer C, Ozenne B, Knudsen GM. A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding. Eur Neuropsychopharmacol. 2020 Apr;33:71-80
  • Mertz C, Krarup S, Jensen CD, Lindholm SEH, Kjær C, Pinborg LH, Bak LK. Aspects of cAMP Signaling in Epileptogenesis and Seizures and Its Potential as Drug Target. Neurochem Res. 2020 Jun;45(6):1247-1255
  • Miller CP, Prener M, Dissing S, Paulson OB. Transcranial low-frequency pulsating electromagnetic fields (T-PEMF) as post-concussion syndrome treatment. Acta Neurol Scand. 2020 Dec;142(6):597-604
  • Nissen K, Klem L, Jeppesen R, Axelsen TM, Christiansen SH, Gøtzsche CR, Pinborg L, Jespersen B, Klemp K, Woldbye D. [Gene therapy for central nervous system disorders]. Ugeskr Laeger. 2020 Jan 13;182(3):V09190535
  • Nørgaard M, Ganz M, Svarer C, Frokjaer VG, Greve DN, Strother SC, Knudsen GM. Different preprocessing strategies lead to different conclusions: A [11C]DASB-PET reproducibility study. J Cereb Blood Flow Metab. 2020 Sep;40(9):1902-1911
  • Ousdal OT, Argyelan M, Narr KL, Abbott C, Wade B, Vandenbulcke M, Urretavizcaya M, Tendolkar I, Takamiya A, Stek ML, Soriano-Mas C, Redlich R, Paulson OB, Oudega ML, Opel N, Nordanskog P, Kishimoto T, Kampe R, Jorgensen A, Hanson LG, Hamilton JP, Espinoza R, Emsell L, van Eijndhoven P, Dols A, Dannlowski U, Cardoner N, Bouckaert F, Anand A, Bartsch H, Kessler U, Oedegaard KJ, Dale AM, Oltedal L; GEMRIC. Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed. Biol Psychiatry. 2020 Mar 1;87(5):451-461
  • Ozenne BMH, Scheike TH, Staerk L, Gerds TA. On the estimation of average treatment effects with right-censored time to event outcome and competing risks. Biom J. 2020 May;62(3):751-763
  • Ozenne B, Fisher PM, Budtz-Jørgensen E. Small sample corrections for Wald tests in Latent Variable Models. J. R. Stat. Soc. C. 2020 Aug; 69:841-861
  • Paulson OB, Vigdis I. Cigarette smoking and cerebral blood flow in a cohort of middle-aged adults. J Cereb Blood Flow Metab. 2020 Apr;40(4):904-905
  • Pfisterer U, Petukhov V, Demharter S, Meichsner J, Thompson JJ, Batiuk MY, Martinez AA, Vasistha NA, Thakur A, Mikkelsen J, Adorjan I, Pinborg LH, Pers TH, von Engelhardt J, Kharchenko PV, Khodosevich K. Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis. Nat Commun. 2020 Oct 7;11(1):5038
  • Sander CY, Hansen HD, Wey HY. Advances in simultaneous PET/MR for imaging neuroreceptor function. J Cereb Blood Flow Metab. 2020 Jun;40(6):1148-1166
  • Shalgunov V, Xiong M, L'Estrade ET, Raval NR, Andersen IV, Edgar FG, Speth NR, Baerentzen SL, Hansen HD, Donovan LL, Nasser A, Peitersen ST, Kjaer A, Knudsen GM, Syvänen S, Palner M, Herth MM. Blocking of efflux transporters in rats improves translational validation of brain radioligands. EJNMMI Res. 2020 Oct 19;10(1):124
  • Spies M, Nasser A, Ozenne B, Jensen PS, Knudsen GM, Fisher PM. Common HTR2A variants and 5-HTTLPR are not associated with human in vivo serotonin 2A receptor levels. Hum Brain Mapp. 2020 Jul 22;41(16):4518-4528
  • Thystrup CK, Vangkilde S, Ozenne B, Stenbæk DS. Severity of self-reported depressive symptoms in a healthy sample is modulated by trait Harm Avoidance, not by 5-HTTLPR polymorphism. Psychiatry Res. 2020 Sep;291:113029
  • Tiger M, Svensson J, Liberg B, Saijo T, Schain M, Halldin C, Farde L, Lundberg J. [11 C]raclopride positron emission tomography study of dopamine-D2/3 receptor binding in patients with severe major depressive episodes before and after electroconvulsive therapy and compared to control subjects. Psychiatry Clin Neurosci. 2020 Apr;74(4):263-269
  • Ulv Larsen SM, Landolt HP, Berger W, Nedergaard M, Knudsen GM, Holst SC. Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep. PLoS Biol. 2020 May 5;18(5):e3000623
  • Vedel AG, Holmgaard F, Danielsen ER, Langkilde A, Paulson OB, Ravn HB, Rasmussen LS, Nilsson JC. Blood pressure and brain injury in cardiac surgery: a secondary analysis of a randomized trial. Eur J Cardiothorac Surg. 2020 Nov 1;58(5):1035-1044
  • Verbeeck J, Ozenne B, Anderson WN. Evaluation of inferential methods for the net benefit and win ratio statistics. J Biopharm Stat. 2020 Sep 2;30(5):765-782
  • Wagner MK, Berg SK, Hassager C, Armand S, Møller JE, Ekholm O, Rasmussen TB, Fisher PM, Knudsen GM, Stenbæk DS. Cognitive impairment and psychopathology in out-of-hospital cardiac arrest survivors in Denmark: The REVIVAL cohort study protocol. BMJ Open. 2020 Sep 29;10(9):e038633
  • Wulff S, Nielsen MØ, Rostrup E, Svarer C, Jensen LT, Pinborg L, Glenthøj BY. The relation between dopamine D2 receptor blockade and the brain reward system: a longitudinal study of first-episode schizophrenia patients. Psychol Med. 2020 Jan;50(2):220-228
  • Younis S, Hougaard A, Christensen CE, Vestergaard MB, Petersen ET, Boer VO, Paulson OB, Ashina M, Marsman A, Larsson HBW. Feasibility of Glutamate and GABA Detection in Pons and Thalamus at 3T and 7T by Proton Magnetic Resonance Spectroscopy. Front Neurosci. 2020 Oct 23;14:559314
Books and book chapters
  • Paulson OB, Gjerris F, Sørensen PS, Waldemarn G, Sørensen JH, Sellebjerg F (eds). Klinisk neurologi og neurokirurgi. 7. udg. København: FADL’s forlag. 2020:1-773.


Original publications in peer-reviewed journals (53)
  • Agren T, Millroth P, Andersson P, Ridzén M, Björkstrand J. Detailed analysis of skin conductance responses during a gambling task: Decision, anticipation, and outcomes. Psychophysiology. 2019 Jun;56(6):e13338
  • Bach Justesen A, Foged MT, Fabricius M, Skaarup C, Hamrouni N, Martens T, Paulson OB, Pinborg LH, Beniczky S. Diagnostic yield of high-density versus low-density EEG: The effect of spatial sampling, timing and duration of recording. Clin Neurophysiol. 2019 Nov;130(11):2060-206
  • Bærentzen S, Casado-Sainz A, Lange D, Shalgunov V, Tejada IM, Xiong M, L'Estrade ET, Edgar FG, Lee H, Herth MM, Palner M. The Chemogenetic Receptor Ligand Clozapine N-Oxide Induces in vivo Neuroreceptor Occupancy and Reduces Striatal Glutamate Levels. Front Neurosci. 2019 Apr 3;13:187
  • Christensen CE, Amin FM, Younis S, Lindberg U, de Koning P, Petersen ET, Paulson OB, Larsson HBW, Ashina M. Sildenafil and calcitonin gene-related peptide dilate intradural arteries: A 3T MR angiography study in healthy volunteers. Cephalalgia. 2019 Feb;39(2):264-273
  • Christensen CE, Younis S, Lindberg U, Boer VO, de Koning P, Petersen ET, Paulson OB, Larsson HBW, Amin FM, Ashina M. Ultra-high field MR angiography in human migraine models: a 3.0 T/7.0 T comparison study. J Headache Pain. 2019 May 6;20(1):48
  • da Cunha-Bang S, Fisher PM, Hjordt LV, Holst K, Knudsen GM. Amygdala reactivity to fearful faces correlates positively with impulsive aggression. Soc Neurosci. 2019 Apr;14(2):162-172
  • da Cunha-Bang S, Ettrup A, Mc Mahon B, Skibsted AP, Schain M, Lehel S, Dyssegaard A, Jørgensen LM, Møller K, Gillings N, Svarer C, Knudsen GM. Measuring endogenous changes in serotonergic neurotransmission with [11C]Cimbi-36 positron emission tomography in humans. Transl Psychiatry. 2019 Apr 11;9(1):134
  • Dam VH, Thystrup CK, Jensen PS, Bland AR, Mortensen EL, Elliott R, Sahakian BJ, Knudsen GM, Frokjaer VG, Stenbæk DS. Psychometric Properties and Validation of the EMOTICOM Test Battery in a Healthy Danish Population. Front Psychol. 2019 Dec 3;10:2660
  • Deen M, Hougaard A, Hansen HD, Svarer C, Eiberg H, Lehel S, Knudsen GM, Ashina M. Migraine is associated with high brain 5-HT levels as indexed by 5-HT4 receptor binding. Cephalalgia. 2019 Apr;39(4):526-532
  • Deen M, Hougaard A, Hansen HD, Schain M, Dyssegaard A, Knudsen GM, Ashina M. Association Between Sumatriptan Treatment During a Migraine Attack and Central 5-HT1B Receptor Binding. JAMA Neurol. 2019 Jul 1;76(7):834-840
  • Duez L, Tankisi H, Hansen PO, Sidenius P, Sabers A, Pinborg LH, Fabricius M, Rásonyi G, Rubboli G, Pedersen B, Leffers AM, Uldall P, Jespersen B, Brennum J, Henriksen OM, Fuglsang-Frederiksen A, Beniczky S. Electromagnetic source imaging in presurgical workup of patients with epilepsy: A prospective study. Neurology. 2019 Feb 5;92(6):e576-e586
  • Dyrvig M, Mikkelsen JD, Lichota J. DNA methylation regulates CHRNA7 transcription and can be modulated by valproate. Neurosci Lett. 2019 Jun 21;704:145-152
  • Ebert SE, Jensen P, Ozenne B, Armand S, Svarer C, Stenbaek DS, Moeller K, Dyssegaard A, Thomsen G, Steinmetz J, Forchhammer BH, Knudsen GM, Pinborg LH. Molecular imaging of neuroinflammation in patients after mild traumatic brain injury: a longitudinal 123 I-CLINDE SPECT study. Eur J Neurol. 2019 Dec;26(12):1426-1432
  • Erritzoe D, Smith J, Fisher PM, Carhart-Harris R, Frokjaer VG, Knudsen GM. Recreational use of psychedelics is associated with elevated personality trait openness: Exploration of associations with brain serotonin markers. J Psychopharmacol. 2019 Sep;33(9):1068-1075
  • Foged MT, Stefánsdóttir A, Brændgaard M, Holm E, Pinborg LH, Sabers A. Why are antiepileptic drugs continued after successful epilepsy surgery in adults? Epilepsy Behav. 2019 Nov;100(Pt A):106452
  • Frederiksen KS, Madsen K, Andersen BB, Beyer N, Garde E, Høgh P, Waldemar G, Hasselbalch SG, Law I. Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease. Alzheimers Dement (N Y). 2019 Jun 7;5:208-215
  • Galea LAM, Frokjaer VG. Perinatal Depression: Embracing Variability toward Better Treatment and Outcomes. Neuron. 2019 Apr 3;102(1):13-16
  • Griem-Krey N, Klein AB, Herth M, Wellendorph P. Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets. J Vis Exp. 2019 Mar 12;(145)
  • Hansen HD, Constantinescu CC, Barret O, Herth MM, Magnussen JH, Lehel S, Dyssegaard A, Colomb J, Billard T, Zimmer L, Tamagnan G, Knudsen GM. Evaluation of [18 F]2FP3 in pigs and non-human primates. J Labelled Comp Radiopharm. 2019 Jan;62(1):34-42
  • Heurling K, Smith R, Strandberg OT, Schain M, Ohlsson T, Hansson O, Schöll M. Regional times to equilibria and their impact on semi-quantification of [18F]AV-1451 uptake. J Cereb Blood Flow Metab. 2019 Nov;39(11):2223-2232
  • Hjordt LV, Stenbæk DS. Sensory processing sensitivity and its association with seasonal affective disorder. Psychiatry Research. 2019 Feb;272:359-364
  • Holm SK, Madsen KS, Vestergaard M, Born AP, Paulson OB, Siebner HR, Uldall P, Baaré WFC. Previous glucocorticoid treatment in childhood and adolescence is associated with long-term differences in subcortical grey matter volume and microstructure. Neuroimage Clin. Neuroimage Clin. 2019;23:101825
  • Holmgaard F, Vedel AG, Rasmussen LS, Paulson OB, Nilsson JC, Ravn HB. The association between postoperative cognitive dysfunction and cerebral oximetry during cardiac surgery: a secondary analysis of a randomised trial. Br J Anaesth. 2019 Aug;123(2):196-205
  • Jensen CG, Krogh SC, Westphael G, Hjordt LV. Mindfulness is positively related to socioeconomic job status and income and independently predicts mental distress in a long-term perspective: Danish validation studies of the Five-Factor Mindfulness Questionnaire. Psychol Assess. 2019 Jan;31(1):e1-e20
  • Johansen A, Holm S, Dall B, Keller S, Kristensen JL, Knudsen GM, Hansen HD. Human biodistribution and radiation dosimetry of the 5-HT2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions. EJNMMI Res. 2019 Jul 31;9(1):71
  • Kjær C, Barzaghi G, Bak LK, Goetze JP, Yde CW, Woldbye D, Pinborg LH, Jensen LJ. Transcriptome analysis in patients with temporal lobe epilepsy. Brain. 2019 Oct 1;142(10):e55
  • Kuypers KP, Ng L, Erritzoe D, Knudsen GM, Nichols CD, Nichols DE, Pani L, Soula A, Nutt D. Microdosing psychedelics: More questions than answers? An overview and suggestions for future research. J Psychopharmacol. 2019 Sep;33(9):1039-1057
  • Lansner J, Jensen CG, Petersen A, Fisher PM, Frokjaer VG, Vangkilde S, Knudsen GM. Three weeks of SSRI administration enhances the visual perceptual threshold - a randomized placebo-controlled study. Psychopharmacology (Berl). 2019 Jun;236(6):1759-1769
  • Larsen LK, Frøkjaer VG, Nielsen JS, Skrobik Y, Winkler Y, Møller K, Petersen M, Egerod I. Delirium assessment in neuro-critically ill patients: A validation study. Acta Anaesthesiol Scand. 2019 Mar;63(3):352-359
  • Larsen HM, Hansen SK, Mikkelsen JD, Hyttel P, Stummann TC. Alpha7 nicotinic acetylcholine receptors and neural network synaptic transmission in human induced pluripotent stem cell-derived neurons. Stem Cell Res. 2019 Dec;41:101642
  • López-Picón FR, Kirjavainen AK, Forsback S, Takkinen JS, Peters D, Haaparanta-Solin M, Solin O. In vivo characterization of a novel norepinephrine transporter PET tracer [18F]NS12137 in adult and immature Sprague-Dawley rats. Theranostics. 2019 Jan 1;9(1):11-19
  • L'Estrade ET, Hansen HD, Falk-Petersen C, Haugaard A, Griem-Krey N, Jung S, Lüddens H, Schirmeister T, Erlandsson M, Ohlsson T, Knudsen GM, Herth MM, Wellendorph P, Frølund B. Synthesis and Pharmacological Evaluation of [11C]4-Methoxy-N-[2-(thiophen-2-yl)imidazo[1,2-a]pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the δ-Subunit-Containing γ-Aminobutyric Acid Type A Receptors. ACS Omega. 2019 May 22;4(5):8846-8851
  • Madsen MK, Fisher PM, Burmester D, Dyssegaard A, Stenbæk DS, Kristiansen S, Johansen SS, Lehel S, Linnet K, Svarer C, Erritzoe D, Ozenne B, Knudsen GM. Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels. Neuropsychopharmacology. 2019 Jun;44(7):1328-1334
  • Magnusson PO, Boer VO, Marsman A, Paulson OB, Hanson LG, Petersen ET. Gamma-aminobutyric acid edited echo-planar spectroscopic imaging (EPSI) with MEGA-sLASER at 7T. Magn Reson Med. 2019 Feb;81(2):773-780
  • Mehta D, Rex-Haffner M, Søndergaard HB, Pinborg A, Binder EB, Frokjaer VG. Genome-wide gene expression in a pharmacological hormonal transition model and its relation to depressive symptoms. Acta Psychiatr Scand. 2019 Jul;140(1):77-84
  • Mehta D, Rex-Haffner M, Søndergaard HB, Pinborg A, Binder EB, Frokjaer VG. Evidence for oestrogen sensitivity in perinatal depression: pharmacological sex hormone manipulation study. Br J Psychiatry. 2019 Sep;215(3):519-527
  • Nørgaard M, Ganz M, Svarer C, Feng L, Ichise M, Lanzenberger R, Lubberink M, Parsey RV, Politis M, Rabiner EA, Slifstein M, Sossi V, Suhara T, Talbot PS, Turkheimer F, Strother SC, Knudsen GM. Cerebral serotonin transporter measurements with [11C]DASB: A review on acquisition and preprocessing across 21 PET centres. J Cereb Blood Flow Metab. 2019 Feb;39(2):210-222
  • Nørgaard M, Ganz M, Svarer C, Frokjaer VG, Greve DN, Strother SC, Knudsen GM. Optimization of preprocessing strategies in Positron Emission Tomography (PET) neuroimaging: A [11C]DASB PET study. NeuroImage. 2019 Jun 1;199:466-479
  • Ozenne B, Tae-Hee C, Mikkelsen IK, Hermier M, Thomalla G, Pedraza S, Roy P, Berthezène Y, Nighoghossian N, Østergaard L, Baron JC, Maucort-Boulch D. Individualized Quantification of the Benefit from Reperfusion Therapy using Stroke Predictive Models. Eur J Neurosci. 2019 Oct;50(8):3251-3260
  • Peinkhofer C#, Knudsen GM, Moretti R, Kondziella D#. Cortical modulation of pupillary function: systematic review. PeerJ. 2019 May 7;7:e6882.
  • Prabhakaran J, DeLorenzo C, Zanderigo F, Knudsen GM, Gilling N, Pratap M, Jorgensen MJ, Daunais J, Kaplan JR, Parsey RV, Mann JJ, Kumar D. In vivo PET Imaging of [11C]CIMBI-5, a 5-HT2AR Agonist Radiotracer in Nonhuman Primates. J Pharm Pharm Sci. 2019;22(1):352-364
  • Sigurdsson ST, Bie P, Nielsen AH, Strandgaard S, Paulson OB. No effect of the angiotensin receptor blocker candesartan on cerebrovascular autoregulation in rats during very high and low sodium intake. J Renin Angiotensin Aldosterone Syst. 2019 Jul-Sep; 20(3): 1470320319874615
  • Stéen EJL, Jørgensen JT, Petersen IN, Nørregaard K, Lehel S, Shalgunov V, Birke A, Edem PE, L'Estrade ET, Hansen HD, Villadsen J, Erlandsson M, Ohlsson T, Yazdani A, Valliant JF, Kristensen JL, Barz M, Knudsen GM, Kjær A, Herth MM. Improved radiosynthesis and preliminary in vivo evaluation of the 11C-labeled tetrazine [11C]AE-1 for pretargeted PET imaging. Bioorg Med Chem Lett. 2019 Apr 15;29(8):986-990
  • Stenbæk DS, Budtz-Jørgensen E, Pinborg A, Jensen PS, Frokjaer VG. Neuroticism modulates mood responses to pharmacological sex hormone manipulation in healthy women. Psychoneuroendocrinology. 2019 Jan;99:251-256
  • Stenbaek DS, Kristiansen S, Burmester D, Madsen MK, Frokjaer VG, Knudsen GM, Fisher PM. Trait Openness and serotonin 2A receptors in healthy volunteers: A positron emission tomography study. Hum Brain Mapp. 2019 May;40(7):2117-2124
  • Sundström Poromaa I, Comasco E, Bäckström T, Bixo M, Jensen P, Frokjaer VG. Negative Association Between Allopregnanolone and Cerebral Serotonin Transporter Binding in Healthy Women of Fertile Age. Front Psychol. 2019 Jan 11;9:2767
  • Svensson JE, Schain M, Plavén-Sigray P, Cervenka S, Tiger M, Nord M, Halldin C, Farde L, Lundberg J. Validity and reliability of extrastriatal [11C]raclopride binding quantification in the living human brain. Neuroimage. 2019 Aug 29;202:116143
  • Tampio L'Estrade E, Xiong M, Shalgunov V, Edgar FG, Volk B, Baerentzen SL, Palner M, Erlandsson M, Ohlsson T, Knudsen GM, Herth MM. Development and Evaluation of Two Potential 5-HT7 Receptor PET Tracers: [18F]ENL09 and [18F]ENL10. ACS Chem Neurosci. 2019 Sep 18;10(9):3961-3968
  • Tozlu C, Ozenne B, Tae-Hee C, Nighoghossian N, Mikkelsen IK, Derex L, Hermier M, Pedraza S, Fiehler J, Østergaard L, Berthezène Y, Baron JC, Maucort-Boulch D. Comparison of classification methods for tissue outcome after ischaemic stroke. Eur J Neurosci. 2019 Nov;50(10):3590-3598
  • Vassilieva A, Olsen MH, Peinkhofer C, Knudsen GM, Kondziella D. Automated pupillometry to detect command following in neurological patients: a proof-of-concept study. PeerJ. 2019 May 13;7:e6929
  • Vedel AG, Holmgaard F, Siersma V, Langkilde A, Paulson OB, Ravn HB, Nilsson JC, Rasmussen LS. Domain-specific cognitive dysfunction after cardiac surgery. A secondary analysis of a randomized trial. Acta Anaesthesiol Scand. 2019 Jul;63(6):730-738
  • Veronese M, Moro L, Arcolin M, Dipasquale O, Rizzo G, Expert P, Khan W, Fisher PM, Svarer C, Bertoldo A, Howes O, Turkheimer FE. Covariance statistics and network analysis of brain PET imaging studies. Sci Rep. 2019 Feb 21;9(1):2496
  • Wickham J, Ledri M, Bengzon J, Jespersen B, Pinborg LH, Englund E, Woldbye DPD, Andersson M, Kokaia M. Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients. Sci Rep. 2019 Dec 18;9(1):19393.
Books and book chapters
  • Holst SC, Werth E, Landolt HP. Pharmacotherapy of Sleep-Wake Disorders. Praxis (Bern 1994). 2019 Jan;108(2):131-138. doi: 10.1024/1661-8157/a003189.
  • Landolt HP, Holst SC, Valomon A. Clinical and Experimental Human Sleep-Wake Pharmacogenetics. Handb Exp Pharmacol. 2019;253:207-241. doi: 10.1007/164_2018_175.
  • Nørgaard M, Ozenne B, Svarer C, Frokjaer VG, Schain M, Strother SC, Ganz M. Preprocessing, Prediction, and Significance: Framework and Application to Brain Imaging. Springer Nature Switzerland AG 2019 D. Shen et al. (Eds.): MICCAI 2019, Lecture Notes in Computer Science 11767, pp. 196-204, 2019.
Multicenter studies without co-authorship
  • Perani D, Iaccarino L, Jacobs AH; IMBI Brain Imaging Working Group. Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies. Alzheimers Dement (Amst). 2019 Apr 16;11:327-332
  • Perani D, Iaccarino L, Lammertsma AA, Windhorst AD, Edison P, Boellaard R, Hansson O, Nordberg A, Jacobs AH; IMBI Project. A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies. Alzheimers Dement. 2019 Aug;15(8):1081-1103


Original publications in peer-reviewed journals (41)
  • Antonsen KK#, Klausen MK#, Brunchmann AS, le Dous N, Jensen ME, Miskowiak KW, Fisher PM, Thomsen GK, Rindom H, Fahmy TP, Vollstaedt-Klein S, Benveniste H, Volkow ND, Becker U, Ekstrøm C, Knudsen GM, Vilsbøll T, Fink-Jensen A. Does glucagon-like peptide-1 (GLP-1) receptor agonist stimulation reduce alcohol intake in patients with alcohol dependence: study protocol of a randomised, double-blinded, placebo-controlled clinical trial. BMJ Open. 2018 Jul 16;8(7):e019562
  • Bailey DL, Pichler BJ, Gückel B, Antoch G, Barthel H, Bhujwalla ZM, Biskup S, Biswal S, Bitzer M, Boellaard R, Braren RF, Brendle C, Brindle K, Chiti A, la Fougère C, Gillies R, Goh V, Goyen M, Hacker M, Heukamp L, Knudsen GM, Krackhardt AM, Law I, Morris JC, Nikolaou K, Nuyts J, Ordonez AA, Pantel K, Quick HH, Riklund K, Sabri O, Sattler B, Troost EGC, Zaiss M, Zender L, Beyer T. Combined PET/MRI: Global Warming-Summary Report of the 6th International Workshop on PET/MRI, March 27-29, 2017, Tübingen, Germany. Mol Imaging Biol. 2018 Feb;20(1):4-20
  • Baroumand AG, van Mierlo P, Strobbe G, Pinborg LH, Fabricius M, Rubboli G, Leffers AM, Uldall P, Jespersen B, Brennum J, Henriksen OM, Beniczky S. Automated EEG source imaging: A retrospective, blinded clinical validation study. Clin Neurophysiol. 2018 Sep 24;129(11):2403-2410
  • Borgsted C, Ozenne⁠ B, Mc Mahon B, Madsen KM, Hjordt⁠ LV, Hageman⁠ I, Baaré⁠ WFC, Knudsen GM, Fisher PM. Amygdala response to emotional faces in seasonal affective disorder. J Affect Disord. 2018 Mar 15;229:288-295
  • Carass A, Cuzzocreo JL, Han S, Hernandez-Castillo CR, Rasser PE, Ganz M, Beliveau V, Dolz J, Ben Ayed I, Desrosiers C, Thyreau B, Romero JE, Coupé P, Manjón JV, Fonov VS, Collins DL, Ying SH, Onyike CU, Crocetti D, Landman BA, Mostofsky SH, Thompson PM, Prince JL. Comparing fully automated state-of-the-art cerebellum parcellation from magnetic resonance images. Neuroimage. 2018 Aug 9;183:150-172
  • da Cunha-Bang S, Fisher PM, Hjordt LV, Perfalk E, Beliveau V, Holst K, Knudsen GM. Men with high serotonin 1B receptor binding respond to provocations with heightened amygdala reactivity. Neuroimage. 2018 Feb 1;166:79-85
  • Deco G, Cruzat J, Cabral J, Knudsen GM, Carhart-Harris RL, Whybrow PC, Logothetis NK, Kringelbach ML. Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Curr Biol. 2018 Oct 8;28(19):3065-3074
  • Deen M, Hansen HD, Hougaard A, Nørgaard M, Eiberg H, Lehel S, Ashina M, Knudsen GM. High brain serotonin levels in migraine between attacks: A 5-HT4 receptor binding PET study. Neuroimage Clin. 2018 Jan 28;18:97-102
  • Deen M, Hansen HD, Hougaard A, da Cunha-Bang S, Nørgaard M, Svarer C, Keller SH, Thomsen C, Ashina M, Knudsen GM. Low 5-HT1B receptor binding in the migraine brain: A PET study. Cephalalgia. 2018 Mar;38(3):519-527
  • Foged MT, Vinter K, Stauning L, Kjær TW, Ozenne B, Beniczky S, Paulson OB, Madsen FF, Pinborg LH; Danish Epilepsy Surgery Group. Verbal learning and memory outcome in selective amygdalohippocampectomy versus temporal lobe resection in patients with hippocampal sclerosis. Epilepsy Behav. 2018 Feb;79:180-187.
  • Hjordt LV, Dam VH, Ozenne B, Hageman I, Mc Mahon B, Mortensen EL, Knudsen GM, Stenbæk DS. Self-perceived personality characteristics in seasonal affective disorder and their implications for severity of depression. Psychiatry Res. 2018 Feb 6;262:108-114
  • Holm E, Foged MT, Beniczky S, Jespersen B, Brennum J, Pinborg LH. Efficacy of the Danish Epilepsy Surgery Programme. Acta Neurol Scand. 2018 Feb;137(2):245-251
  • Holm SK, Madsen KS, Vestergaard M, Paulson OB, Uldall P, Siebner HR, Born AP, Baaré WFC. Total brain, cortical and white matter volumes in children previously treated with glucocorticoids. Pediatr Res. 2018 Apr;83(4):804-812
  • Holst SC, Landolt HP. Sleep-Wake Neurochemistry. Sleep Med Clin. 2018 Jun;13(2):137-146
  • Hornboll B, Macoveanu J, Nejad A, Rowe J, Elliott R, Knudsen GM, Siebner HR, Paulson OB. Neuroticism predicts the impact of serotonin challenges on fear processing in subgenual anterior cingulate cortex. Sci Rep. 2018 Dec 17;8(1):17889
  • Ip CT, Ganz M, Ozenne B, Sluth LB, Gram M, Viardot G, l'Hostis P, Danjou P, Knudsen GM, Christensen SR. Pre-intervention test-retest reliability of EEG and ERP over four recording intervals. Int J Psychophysiol. 2018 Sep 22;134:30-43
  • Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Hansson O, Klunk WE, van der Flier WM, Villemagne VL, Frisoni GB, Fleisher AS, Lleó A, Mintun MA, Wallin A, Engelborghs S, Na DL, Chételat G, Molinuevo JL, Landau SM, Mattsson N, Kornhuber J, Sabri O, Rowe CC, Parnetti L, Popp J, Fladby T, Jagust WJ, Aalten P, Lee DY, Vandenberghe R, Resende de Oliveira C, Kapaki E, Froelich L, Ivanoiu A, Gabryelewicz T, Verbeek MM, Sanchez-Juan P, Hildebrandt H, Camus V, Zboch M, Brooks DJ, Drzezga A, Rinne JO, Newberg A, de Mendonça A, Sarazin M, Rabinovici GD, Madsen K, Kramberger MG, Nordberg A, Mok V, Mroczko B, Wolk DA, Meyer PT, Tsolaki M, Scheltens P, Verhey FRJ, Visser PJ; Amyloid Biomarker Study Group. Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia. JAMA Psychiatry. 2018 Jan 1;75(1):84-95
  • Johansen A, Hansen HD, Svarer C, Lehel S, Leth-Petersen S, Kristensen JL, Gillings N, Knudsen GM. The importance of small polar radiometabolites in molecular neuroimaging: A PET study with [11C]Cimbi-36 labeled in two positions. J Cereb Blood Flow Metab. 2018 Apr;38(4):659-668
  • Jørgensen LM, Weikop P, Svarer C, Feng L, Keller SH, Knudsen GM. Cerebral serotonin release correlates with [11C]AZ10419369 PET measures of 5-HT1B receptor binding in the pig brain. J Cereb Blood Flow Metab. 2018 Jul;38(7):1243-1252
  • Kirjavainen AK, Forsback S, López-Picón FR, Marjamäki P, Takkinen J, Haaparanta-Solin M, Peters D, Solin O. 18F-labeled norepinephrine transporter tracer [18F]NS12137: radiosynthesis and preclinical evaluation. Nucl Med Biol. 2018 Jan;56:39-46
  • Mc Mahon B, Nørgaard M, Svarer C, Andersen SB, Madsen MK, Baaré WFC, Madsen J, Frokjaer VG, Knudsen GM. Seasonality-resilient individuals downregulate their cerebral 5-HT transporter binding in winter - A longitudinal combined 11C-DASB and 11C-SB207145 PET study. Eur Neuropsychopharmacol. 2018 Oct;28(10):1151-1160
  • Medger K, Bennett NC, Chimimba CT, Oosthuizen MK, Mikkelsen JD, Coen CW. Analysis of gonadotrophin-releasing hormone-1 and kisspeptin neuronal systems in the nonphotoregulated seasonally breeding eastern rock elephant-shrew (Elephantulus myurus). J Comp Neurol. 2018 Oct 15;526(15):2388-2405
  • Miskowiak KW, Macoveanu J, Jørgensen MB, Støttrup MM, Ott CV, Jensen HM, Jørgensen A, Harmer J, Paulson OB, Kessing LV, Siebner HR. Neural response after a single ECT session during retrieval of emotional self-referent words in depression: a randomized, sham-controlled fMRI study. Int J Neuropsychopharmacol. 2018 Mar 1;21(3):226-235
  • Miskowiak KW, Macoveanu J, Jørgensen MB, Ott CV, Støttrup MM, Jensen HM, Jørgensen A, Harmer CJ, Paulson OB, Siebner HR, Kessing LV. Effect of electroconvulsive therapy on neural response to affective pictures: A randomized, sham-controlled fMRI study. Eur Neuropsychopharmacol. 2018 Aug;28(8):915-924
  • Mora S, Merchan A, Vilchez O, Aznar S, Klein AB, Ultved L, Campa L, Suñol C, Flores P, Moreno M. Reduced cortical serotonin 5-HT2A receptor binding and glutamate activity in high compulsive drinker rats. Neuropharmacology. 2018 Sep 7;143:10-19
  • Oltedal L, Narr KL, Abbott C, Anand A, Argyelan M, Bartsch H, Dannlowski U, Dols A, van Eijndhoven P, Emsell L, Erchinger VJ, Espinoza R, Hahn T, Hanson LG, Hellemann G, Jorgensen MB, Kessler U, Oudega ML, Paulson OB, Redlich R, Sienaert P, Stek ML, Tendolkar I, Vandenbulcke M, Oedegaard KJ, Dale AM. Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy. Biol Psychiatry. 2018 Oct 15;84(8):574-581
  • Ott CV, Vinberg M, Bowie CR, Christensen EM, Knudsen GM, Kessing LV, Miskowiak KW. Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial. Trials. 2018 Sep 12;19(1):487
  • Overgaard A, Lieblich SE, Richardson R, Galea LAM, Frokjaer VG. Paroxetine blunts the corticosterone response to swim-induced stress and increases depressive-like behavior in a rat model of postpartum depression. Psychoneuroendocrinology. 2018 Mar;89:223-228
  • Peinkhofer C, Martens P, Grand J, Truelsen T, Knudsen GM, Kjaergaard J, Kondziella D. Influence of Strategic Cortical Infarctions on Pupillary Function. Front Neurol. 2018 Oct 29;9:916
  • Petersen JZ, Schmidt LS, Vinberg M, Jørgensen MB, Hageman I, Ehrenreich H, Knudsen GM, Kessing LV, Miskowiak KW. Effects of recombinant human erythropoietin on cognition and neural activity in remitted patients with mood disorders and first-degree relatives of patients with psychiatric disorders: a study protocol for a randomized controlled trial. Trials. 2018 Nov 6;19(1):611
  • Pinborg L, Jespersen B, Beniczky S, Fabricius M, Rasonyi G, Uldall P, Tsiropoulos I, Leffers AM, Madsen C, Foged M, Ziebell M, Henriksen O, Jørgensen M, Vinter K, Stauning L, Broholm H, Brennum J, Sabers A, Rubboli G. [Epilepsy surgery]. Ugeskr Laeger. 2018 Mar 26;180(13)
  • Runegaard AH, Sørensen AT, Fitzpatrick CM, Jørgensen SH, Petersen AV, Hansen NW, Weikop P, Andreasen JT, Mikkelsen JD, Perrier JF, Woldbye D, Rickhag M, Wortwein G, Gether U. Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons. eNeuro. 2018 Jun 18;5(3):1-28
  • Sharma P, Scherg M, Pinborg LH, Fabricius M, Rubboli G, Pedersen B, Leffers AM, Uldall P, Jespersen B, Brennum J, Henriksen OM, Beniczky S. Ictal and interictal electric source imaging in pre-surgical evaluation: a prospective study. Eur J Neurol. 2018 Sep;25(9):1154-1160
  • Skibsted AP, Amiri M, Fisher PM, Sidaros A, Hribljan MC, Larsen VA, Højgaard JLS, Nikolic M, Hauerberg J, Fabricius ME, Knudsen GM, Møller K, Kondziella D. Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG (CONNECT-ME): Protocol for a Longitudinal Prospective Study and a Tertiary Clinical Care Service. Front Neurol. 2018 Nov 27;9:1012
  • Steensberg AT, Olsen AS, Litman M, Jespersen B, Kolko M, Pinborg LH. Visual field defects after temporal lobe resection for epilepsy. Seizure. 2018 Jan;54:1-6
  • T L'Estrade E, Hansen HD, Erlandsson M, Ohlsson TG, Knudsen GM, Herth MM. Classics in Neuroimaging: The Serotonergic 2A Receptor System-from Discovery to Modern Molecular Imaging. ACS Chem Neurosci. 2018 Jun 20;9(6):1226-1229
  • Vedel AG, Holmgaard F, Rasmussen LS, Langkilde A, Paulson OB, Lange T, Thomsen C, Olsen PS, Ravn HB, Nilsson JC. High-target versus low-target blood pressure management during cardiopulmonary bypass to prevent cerebral injury in cardiac surgery patients: A randomized controlled trial. Circulation. 2018 Apr 24;137(17):1770-1780
  • Villadsen J, Hansen HD, Jørgensen LM, Keller SH, Andersen FL, Petersen IN, Knudsen GM, Svarer C. Automatic delineation of brain regions on MRI and PET images from the pig. J Neurosci Methods. 2018 Jan 15;294:51-58
  • Wickham J, Brödjegård NG, Vighagen R, Pinborg LH, Bengzon J, Woldbye DPD, Kokaia M, Andersson M. Prolonged life of human acute hippocampal slices from temporal lobe epilepsy surgery. Sci Rep. 2018 Mar 7;8(1):4158
  • Younis S, Hougaard A, Christensen CE, Vestergaard MB, Petersen ET, Paulson OB, Larsson HBW, Ashina M. Effects of sildenafil and calcitonin gene-related peptide on brainstem glutamate levels: a pharmacological proton magnetic resonance spectroscopy study at 3.0 T. J Headache Pain. 2018 Jun 18;19(1):44
  • Østergaard L, Jørgensen MB, Knudsen GM. Low on Energy? An energy supply-demand perspective on stress and depression. Neurosci Biobehav Rev. 2018 Nov;94:248-270
Books and book chapters
  • Herth MM, Knudsen GM. PET Imaging of the 5-HT2A Receptor System: A Tool to Study the Receptor’s In Vivo Brain Function. In: Guiard BP, Di Giovanni G. (Eds.). 5HT2A Receptors in the Central Nervous System. The Receptors, Vol. 32. Springer International Publishing, New York (USA). ISBN: 9783319704722


Original publications in peer-reviewed journals (43)
  • Beliveau V, Ganz M, Feng L, Ozenne B, Højgaard L, Fisher PM, Svarer C, Greve DN, Knudsen GM. A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System. J Neurosci. 2017 Jan 4;37(1):120-128
  • Celicanin M, Blaabjerg M, Maersk-Moller C, Beniczky S, Marner L, Thomsen C, Back FW, Kondziella D, Andersen H, Somnier F, Illes Z, Pinborg LH. Autoimmune encephalitis associated with voltage-gated potassium channels-complex and leucine-rich glioma-inactivated 1 antibodies - a national cohort study. Eur J Neurol. 2017 Aug;24(8):999-1005
  • da Cunha-Bang S, Fisher PM, Hjordt LV, Perfalk E, Persson Skibsted A, Bock C, Ohlhues Baandrup A, Deen M, Thomsen C, Sestoft DM, Knudsen GM. Violent offenders respond to provocations with high amygdala and striatal reactivity. Soc Cogn Affect Neurosci. 2017 May 1;12(5):802-810
  • da Cunha-Bang S, Hjordt LV, Perfalk E, Beliveau V, Bock C, Lehel S, Thomsen C, Sestoft D, Svarer C, Knudsen GM. Serotonin 1B receptor binding is associated with trait anger and level of psychopathy in violent offenders. Biol Psychiatry. 2017 Aug 15;82(4):267-274
  • da Cunha-Bang S, Hjordt LV, Dam VH, Stenbæk DS, Sestoft D, Knudsen GM. Anterior cingulate serotonin 1B receptor binding is associated with emotional response inhibition. J Psychiatr Res. 2017 Sep;92:199-204
  • Deen M, Christensen CE, Hougaard A, Hansen HD, Knudsen GM, Ashina M. Serotonergic mechanisms in the migraine brain - a systematic review. Cephalalgia. 2017 Mar;37(3):251-264
  • Dickson JC, Tossici-Bolt L, Sera T, Booij J, Ziebell M, Morbelli S, Assenbaum-Nan S, Borght TV, Pagani M, Kapucu OL, Hesse S, Van Laere K, Darcourt J, Varrone A, Tatsch K. The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [123I]FP-CIT SPECT imaging. EJNMMI Res. 2017 Dec;7(1):10
  • Edgar FG, Hansen HD, Leth-Petersen S, Ettrup A, Kristensen JL, Knudsen GM, Herth MM. Synthesis, radiofluorination and preliminary evaluation of the potential 5-HT2A receptor agonists [18 F]Cimbi-92 and [18 F]Cimbi-150. J Labelled Comp Radiopharm. 2017 Oct;60(12):586-591
  • Feng L, Jensen P, Thomsen G, Dyssegaard A, Svarer C, Knudsen LV, Møller K, Thomsen C, Mikkelsen JD, Guilloteau D, Knudsen GM, Pinborg LH. The variability of translocator protein signal in brain and blood of genotyped healthy humans using in vivo 123I-CLINDE SPECT imaging - a test-retest study. J Nucl Med. 2017 Jun;58(6):989-995
  • Fisher PM, Larsen CB, Beliveau V, Henningsson S, Pinborg A, Holst KK, Jensen PS, Svarer C, Siebner HR, Knudsen GM, Frokjaer VG. Pharmacologically Induced Sex Hormone Fluctuation Effects on Resting-State Functional Connectivity in a Risk Model for Depression: A Randomized Trial. Neuropsychopharmacology. 2017 Jan;42(2):446-453
  • Fisher PM, Ozenne B, Svarer C, Adamsen D, Lehel S, Baaré WF, Jensen PS, Knudsen GM. BDNF val66met association with serotonin transporter binding in healthy humans. Transl Psychiatry. 2017 Feb 14;7(2):e1029
  • Foged MT, Lindberg U, Vakamudi K, Larsson HBW, Pinborg LH, Kjær TW, Fabricius M, Svarer C, Ozenne B, Thomsen C, Beniczky S, Paulson OB, Posse S. Safety and EEG data quality of concurrent high-density EEG and high-speed fMRI at 3 Tesla. PLoS One. 2017 May 26;12(5):e0178409
  • Ganz M, Feng L, Hansen HD, Beliveau V, Svarer C, Knudsen GM, Greve DN. Cerebellar heterogeneity and its impact on PET data quantification of 5-HT receptor radioligands. J Cereb Blood Flow Metab. 2017 Sep;37(9):3243-3252
  • Ganz M, Kondermann D, Andrulis J, Knudsen GM, Maier-Hein L. Crowdsourcing for error detection in cortical surface delineations. Int J Comput Assist Radiol Surg. 2017 Jan;12(1):161-166
  • Hansen HD, Mandeville JB, Sander CY, Hooker JM, Catana C, Rosen BR, Knudsen GM. Functional characterization of 5-HT1B receptor drugs in nonhuman primates using simultaneous PET-MR. J Neurosci. 2017 Nov 1;37(44):10671-10678
  • Hansen HH, Weikop P, Mikkelsen MD, Rode F, Mikkelsen JD. The pan-Kv7 (KCNQ) Channel Opener Retigabine Inhibits Striatal Excitability by Direct Action on Striatal Neurons In Vivo. Basic Clin Pharmacol Toxicol. 2017 Jan;120(1):46-51
  • Henningsen JB, Ancel C, Mikkelsen JD, Gauer F, Simonneaux V. Roles of RFRP-3 in the daily and seasonal regulation of reproductive activity in female Syrian hamsters. Endocrinology. 2017 Mar 1;158(3):652-663
  • Hjordt LV, Stenbæk DS, Madsen KS, Mc Mahon B, Jensen CG, Vestergaard M, Hageman I, Meder D, Hasselbalch SG, Knudsen GM. State-dependent alterations in inhibitory control and emotional face identification in seasonal affective disorder. J Abnorm Psychol. 2017 Apr;126(3):291-300
  • Hjordt LV, Stenbæk DS, Ozenne B, Mc Mahon B, Hageman I, Hasselbalch SG, Knudsen GM. Season-independent cognitive deficits in seasonal affective disorder and their relation to depressive symptoms. Psychiatry Res. 2017 Jul 30;257:219-226
  • Jennings KJ, Chasles M, Cho H, Mikkelsen J, Bentley G, Keller M, Kriegsfeld LJ. The Preoptic Area and the RFamide-Related Peptide Neuronal System Gate Seasonal Changes in Chemosensory Processing. Integr Comp Biol. 2017 Nov 1;57(5):1055-1065
  • Jensen CH, Hansen HD, Bay T, Vogensen SB, Lehel S, Thiesen L, Bundgaard C, Clausen RP, Knudsen GM, Herth MM, Wellendorph P, Frølund B. Radiosynthesis and Evaluation of [11C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid Binding Sites. ACS Chem Neurosci. 2017 Jan 18;8(1):22-27
  • Jørgensen LM, Weikop P, Villadsen J, Visnapuu T, Ettrup A, Hansen HD, Baandrup AO, Andersen FL, Bjarkam CR, Thomsen C, Jespersen B, Knudsen GM. Cerebral 5-HT release correlates with [11C]Cimbi36 PET measures of 5-HT2A receptor occupancy in the pig brain. J Cereb Blood Flow Metab. 2017 Feb;37(2):425-434
  • Jørgensen LM, Piil K, Bashir A, Larsen MB, Poggenborg PS, Bjørck S, Fugleholm K. Is one-stop surgery for carpal tunnel syndrome safe? A retrospective long-term follow-up study in a neurosurgical unit in Copenhagen. BMJ Open. 2017 Sep 25;7(9):e016103
  • Kessing LV, Munkholm K, Faurholt-Jepsen M, Miskowiak KW, Nielsen LB, Frikke-Schmidt R, Ekstrøm C, Winther O, Pedersen BK, Poulsen HE, McIntyre RS, Kapczinski F, Gattaz WF, Bardram J, Frost M, Mayora O, Knudsen GM, Phillips M, Vinberg M. The Bipolar Illness Onset study - research protocol for the BIO cohort study. BMJ Open. 2017 Jun 23;7(6):e015462
  • Kondziella D, Fisher PM, Larsen VA, Hauerberg J, Fabricius M, Møller K, Knudsen GM. Functional MRI for Assessment of the Default Mode Network in Acute Brain Injury. Neurocrit Care. 2017 Dec;27(3):401-406
  • Lauritzen MH, Magnusson P, Laustsen C, Butt SA, Ardenkjær-Larsen JH, Søgaard LV, Paulson OB, Åkeson P. Imaging Regional Metabolic Changes in the Ischemic Rat Heart In Vivo Using Hyperpolarized [1-13C]Pyruvate. Tomography. 2017 Sep;3(3):123-130
  • Midttun M, Azad BB, Broholm R, Jensen LT, Svarer C, Jensen PE. Heat-washout measurements compared to distal blood pressure and perfusion in orthopaedic patients with foot ulcers. Clin Physiol Funct Imaging. 2017 Jan;37(1):79-83
  • Miskowiak KW, Kessing LV, Ott CV, Macoveanu J, Harmer CJ, Jørgensen A, Revsbech R, Jensen HM, Paulson OB, Siebner HR, Jørgensen MB. Does a single session of electroconvulsive therapy alter the neural response to emotional faces in depression? A randomised sham-controlled functional magnetic resonance imaging study. J Psychopharmacol. 2017 Sep;31(9):1215-1224
  • Nørbak-Emig H, Pinborg LH, Raghava JM, Svarer C, Baaré WFC, Allerup P, Friberg L, Rostrup E, Glenthøj B, Ebdrup BH. Extrastriatal dopamine D2/3 receptors and cortical grey matter volumes in antipsychotic-naïve schizophrenia patients before and after initial antipsychotic treatment. World J Biol Psychiatry. 2017 Oct;18(7):539-549
  • Nørgaard M, Ganz M, Svarer C, Fisher PM, Churchill NW, Beliveau V, Grady C, Strother SC, Knudsen GM. Brain Networks Implicated in Seasonal Affective Disorder: A Neuroimaging PET Study of the Serotonin Transporter. Front Neurosci. 2017 Nov 3;11:614
  • Olsen AS, Steensberg AT, la Cour M, Kjaer TW, Damato B, Pinborg LH, Kolko M. Can DMCO Detect Visual Field Loss in Neurological Patients? A Secondary Validation Study. Ophthalmic Res. 2017;58(2):85-93
  • Perfalk E, Cunha-Bang SD, Holst KK, Keller S, Svarer C, Knudsen GM, Frokjaer VG. Testosterone levels in healthy men correlate negatively with serotonin 4 receptor binding. Psychoneuroendocrinology. 2017 Mar 22;81:22-28
  • Petersen IN, Villadsen J, Hansen HD, Madsen J, Jensen AA, Gillings N, Lehel S, Herth MM, Knudsen GM, Kristensen JL. 18F-Labelling of electron rich iodonium ylides: application to the radiosynthesis of potential 5-HT2A receptor PET ligands. Org Biomol Chem. 2017 May 23;15(20):4351-4358
  • Rasmussen JH, Nørgaard M, Hansen AE, Vogelius IR, Aznar MC, Johannesen HH, Costa J, Engberg AM, Kjær A, Specht L, Fischer BM. Feasibility of Multiparametric Imaging with PET/MR in Head and Neck Squamous Cell Carcinoma. J Nucl Med. 2017 Jan;58(1):69-74
  • Skibsted AP, Cunha-Bang SD, Carré JM, Hansen AE, Beliveau V, Knudsen GM, Fisher PM. Aggression-related brain function assessed with the Point Subtraction Aggression Paradigm in fMRI. Aggress Behav. 2017 Nov;43(6):601-610
  • Stéen EJ, Nyberg N, Lehel S, Andersen VL, Di Pilato P, Knudsen GM, Kristensen JL, Herth MM. Development of a simple proton nuclear magnetic resonance-based procedure to estimate the approximate distribution coefficient at physiological pH (logD7.4): Evaluation and comparison to existing practices. Bioorg Med Chem Lett. 2017 Jan 15;27(2):319-322
  • Stenbæk DS, Fisher PM, Ozenne B, Andersen E, Hjordt LV, McMahon B, Hasselbalch SG, Frokjaer VG, Knudsen GM. Brain serotonin 4 receptor binding is inversely associated with verbal memory recall. Brain Behav. 2017 Mar 17;7(4):e00674
  • Stenbæk DS, Dam VH, Fisher PM, Hansen N, Hjordt LV, Frøkjær VG. No evidence for a role of the serotonin 4 receptor in five-factor personality traits: A positron emission tomography brain study. PLoS One. 2017 Sep 7;12(9):e0184403
  • Tossici-Bolt L, Dickson JC, Sera T, Booij J, Asenbaun-Nan S, Bagnara MC, Borght TV, Jonsson C, de Nijs R, Hesse S, Koulibaly PM, Akdemir UO, Koole M, Tatsch K, Varrone A. [123I]FP-CIT ENC-DAT normal database: the impact of the reconstruction and quantification methods. EJNMMI Phys. 2017 Dec;4(1):8
  • Tuominen L, Miettunen J, Cannon DM, Drevets WC, Frokjaer VG, Hirvonen J, Ichise M, Jensen PS, Keltikangas-Järvinen L, Klaver JM, Knudsen GM, Takano A, Suhara T, Hietala J. Neuroticism associates with cerebral in vivo serotonin transporter binding differently in males and females. Int J Neuropsychopharmacol. 2017 Dec 1;20(12):963-970
  • Vestergaard M, Holm SK, Uldall P, Siebner HR, Paulson OB, Baaré WFC, Madsen KS. Glucocorticoid treatment earlier in childhood and adolescence show dose-response associations with diurnal cortisol levels. Dev Psychobiol. 2017 Dec;59(8):1010-1020
  • Wichern F, Jensen MM, Christensen DZ, Mikkelsen JD, Gondré-Lewis MC, Thomsen MS. Perinatal nicotine treatment induces transient increases in NACHO protein levels in the rat frontal cortex. Neuroscience. 2017 Jan 25;346:278-283
  • Yang KC, Stepanov V, Martinsson S, Ettrup A, Takano A, Knudsen GM, Halldin C, Farde L, Finnema SJ. Fenfluramine Reduces [11C]Cimbi-36 Binding to the 5-HT2A Receptor in the Nonhuman Primate Brain. Int J Neuropsychopharmacol. 2017 Sep 1;20(9):683-691


Original publications in peer-reviewed journals (47)
  • Albert NL, Unterrainer M, Diemling M, Xiong G, Bartenstein P, Koch W, Varrone A, Dickson JC, Tossici-Bolt L, Sera T, Asenbaum S, Booij J, Kapucu LÖ, Kluge A, Ziebell M, Darcourt J, Nobili F, Pagani M, Sabri O, Hesse S, Borght TV, Van Laere K, Tatsch K, la Fougère C. Implementation of the European multicentre database of healthy controls for [(123)I]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes. Eur J Nucl Med Mol Imaging. 2016 Jul;43(7):1315-22
  • Andersson M, Avaliani N, Svensson A, Wickham J, Pinborg LH, Jespersen B, Christiansen SH, Bengzon J, Woldbye DP, Kokaia M. Optogenetic control of human neurons in organotypic brain cultures. Sci Rep. 2016 Apr 21;6:24818
  • Arvaniti M, Jensen MM, Soni N, Wang H, Klein AB, Thiriet N, Pinborg LH, Muldoon PP, Wienecke J, Imad Damaj M, Kohlmeier KA, Gondré-Lewis MC, Mikkelsen JD, Thomsen MS. Functional interaction between Lypd6 and nicotinic acetylcholine receptors. J Neurochem. 2016 Sep;138(6):806-20
  • Beniczky S, Duez L, Scherg M, Hansen PO, Tankisi H, Sidenius P, Sabers A, Pinborg LH, Uldall P, Fuglsang-Frederiksen A. Visualizing spikes in source-space: Rapid and efficient evaluation of magnetoencephalography. Clin Neurophysiol. 2016 Feb;127(2):1067-72
  • Blomster LV, Strøbaek D, Hougaard C, Klein J, Pinborg LH, Mikkelsen JD, Christophersen P. Quantification of the functional expression of the Ca2+ -activated K+ channel KCa 3.1 on microglia from adult human neocortical tissue. Glia. 2016 Dec;64(12):2065-2078
  • Bortz DM, Upton BA, Mikkelsen JD, Bruno JP. Positive allosteric modulators of the α7 nicotinic acetylcholine receptor potentiate glutamate release in the prefrontal cortex of freely-moving rats. Neuropharmacology. 2016 Dec;111:78-91
  • Buchert R, Kluge A, Tossici-Bolt L, Dickson J, Bronzel M, Lange C, Asenbaum S, Booij J, Atay Kapucu LÖ, Svarer C, Koulibaly PM, Nobili F, Pagani M, Sabri O, Sera T, Tatsch K, Vander Borght T, Van Laere K, Varrone A, Iida H. Reduction in camera-specific variability in [123I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls. Eur J Nucl Med Mol Imaging. 2016 Jul;43(7):1323-36
  • da Cunha-Bang S, Mc Mahon B, MacDonald Fisher P, Jensen PS, Svarer C, Moos Knudsen G. High trait aggression in men is associated with low 5-HT levels, as indexed by 5-HT4 receptor binding. Soc Cogn Affect Neurosci. 2016 Apr;11(4):548-55
  • Dam JH, Bender D, Peters D, Någren K. [(11)C]NS9531, [(11)C]NS9762 and [(11)C]NS6417, specific SERT tracers: pre-clinical evaluation in pigs and optimization of synthesis conditions using [(11)C]methyl triflate. Nucl Med Biol. 2016 Jan;43(1):42-51
  • Dogonowski AM, Blinkenberg M, Paulson OB, Sellebjerg F, Sørensen PS, Siebner HR, Madsen KH. Recovery from an acute relapse is associated with changes in motor resting-state connectivity in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2016 Aug;87(8):912-4
  • Donat CK, Gaber K, Meixensberger J, Brust P, Pinborg LH, Hansen HH, Mikkelsen JD. Changes in Binding of [123I]CLINDE, a High-Affinity Translocator Protein 18 kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury. Neuromolecular Med. 2016 Jun;18(2):158-69
  • Ettrup A, Svarer C, McMahon B, da Cunha-Bang S, Lehel S, Møller K, Dyssegaard A, Ganz M, Beliveau V, Jørgensen LM, Gillings N, Knudsen GM. Serotonin 2A receptor agonist binding in the human brain with [(11)C]Cimbi-36: Test-retest reproducibility and head-to-head comparison with the antagonist [(18)F]altanserin. Neuroimage. 2016 Apr 15;130:167-74
  • Feng L, Svarer C, Madsen K, Ziebell M, Dyssegaard A, Ettrup A, Hansen HD, Lehel S, Yndgaard S, Paulson OB, Knudsen GM, Pinborg LH. Design of Infusion Schemes for Neuroreceptor Imaging: Application to [11C]Flumazenil-PET Steady-State Study. Biomed Res Int. 2016;2016:9132840
  • Greve DN, Salat DH, Bowen SL, Izquierdo-Garcia D, Schultz AP, Catana C, Becker JA, Svarer C, Knudsen G, Sperling RA, Johnson KA. Different partial volume correction methods lead to different conclusions: An 18F-FDG-PET study of aging. Neuroimage. 2016 May 15;132:334-43
  • Hansen HH, Fabricius K, Barkholt P, Mikkelsen JD, Jelsing J, Pyke C, Knudsen LB, Vrang N. Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson's disease. Brain Res. 2016 Sep 1;1646:354-65
  • Henningsen JB, Poirel VJ, Mikkelsen JD, Tsutsui K, Simonneaux V, Gauer F. Sex differences in the photoperiodic regulation of RF-amide related peptide (RFRP) and its receptor GPR147 in the Syrian hamster. J Comp Neurol. 2016 Jun 15;524(9):1825-38
  • Herth MM, Petersen IN, Hansen HD, Hansen M, Ettrup A, Jensen AA, Lehel S, Dyssegaard A, Gillings N, Knudsen GM, Kristensen JL. Synthesis and evaluation of 18F-labeled 5-HT2A receptor agonists as PET ligands. Nucl Med Biol. 2016 Apr 19;43(8):455-462
  • Hervig ME, Thomsen MS, Kalló I, Mikkelsen JD. Acute phencyclidine administration induces c-Fos-immunoreactivity in interneurons in cortical and subcortical regions. Neuroscience. 2016 Oct 15;334:13-25
  • Jakobsen GR, Fisher PM, Dyssegaard A, McMahon B, Holst KK, Lehel S, Svarer C, Jensen PS, Knudsen GM, Frokjaer VG. Brain serotonin 4 receptor binding is associated with the cortisol awakening response. Psychoneuroendocrinology. 2016 May;67:124-32
  • Jensen CG, Niclasen J, Vangkilde SA, Petersen A, Hasselbalch SG. General Inattentiveness Is a Long-Term Reliable Trait Independently Predictive of Psychological Health: Danish Validation Studies of the Mindful Attention Awareness Scale. Psychol Assess. 2016 May;28(5):e70-87
  • Jensen CG, Hjordt LV, Stenbæk DS, Andersen E, Back SK, Lansner J, Hageman I, Dam H, Nielsen AP, Knudsen GM, Frokjaer VG, Hasselbalch SG. Development and Psychometric Validation of the Verbal Affective Memory Test. Memory. 2016 Oct;24(9):1208-23
  • Jorgensen A, Magnusson P, Hanson LG, Kirkegaard T, Benveniste H, Lee H, Svarer C, Mikkelsen JD, Fink-Jensen A, Knudsen GM, Paulson OB, Bolwig TG, Jorgensen MB. Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression. Acta Psychiatrica Scandinavica. 2016 Feb 3;133(2):154-164
  • Klein AB, Bay T, Villumsen IS, Falk-Petersen CB, Marek A, Frølund B, Clausen RP, Hansen HD, Knudsen GM, Wellendorph P. Autoradiographic imaging and quantification of the high-affinity GHB binding sites in rodent brain using 3H-HOCPCA. Neurochem Int. 2016 Sep 8;100:138-145
  • Knudsen GM, Jensen PS, Erritzoe D, Baaré WFC, Ettrup A, Fisher PM, Gillings N, Hansen HD, Hansen LK, Hasselbalch SG, Henningsson S, Herth MM, Holst KK, Iversen P, Kessing LV, Macoveanu J, Madsen KS, Mortensen EL, Nielsen FÅ, Paulson OB, Siebner HR, Stenbæk DS, Svarer C, Jernigan TL, Strother SC, Frokjaer VG. The Center for Integrated Molecular Brain Imaging (Cimbi) Database. NeuroImage. 2016 Jan 1;124(Pt B):1213-1219
  • Kondziella D, Friberg CK, Frokjaer VG, Fabricius M, Møller K. Preserved consciousness in vegetative and minimal conscious states: systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2016 May;87(5):485-92
  • Larsen IU, Mortensen EL, Vinther-Jensen T, Nielsen JE, Knudsen GM, Vogel A. Personality traits in Huntington's disease: An exploratory study of gene expansion carriers and non-carriers. Am J Med Genet B Neuropsychiatr Genet. 2016 Dec;171(8):1153-1160
  • Laursen HR, Henningsson S, Macoveanu J, Jernigan TL, Siebner HR, Holst KK, Skimminge A, Knudsen GM, Ramzøy TZ, Erritzoe D. Serotonergic neurotransmission in emotional processing: New evidence from long-term recreational poly-drug ecstasy use. J Psychopharmacol. 2016 Dec;30(12):1296-1304
  • Leth-Petersen S, Gabel-Jensen C, Gillings N, Lehel S, Hansen HD, Knudsen GM, Kristensen JL. Metabolic fate of hallucinogenic NBOMes. Chem Res Toxicol. 2016 Jan 19;29(1):96-100
  • Lyukmanova EN, Shulepko MA, Kudryavtsev D, Bychkov ML, Kulbatskii DS, Kasheverov IE, Astapova MV, Feofanov AV, Thomsen MS, Mikkelsen JD, Shenkarev ZO, Tsetlin VI, Dolgikh DA, Kirpichnikov MP. Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor. PLoS One. 2016 Feb 23;11(2):e0149733
  • Macoveanu J, Henningsson S, Pinborg A, Jensen PS, Knudsen GM, Frokjaer VG, Siebner HR. Sex-Steroid Hormone Manipulation Reduces Brain Response to Reward. Neuropsychopharmacology. 2016 Mar;41(4):1057-65
  • Macoveanu J, Fisher PM, Madsen MK, Mc Mahon B, Knudsen GM, Siebner HR. Bright-light intervention induces a dose-dependent increase in striatal response to risk in healthy volunteers. Neuroimage. 2016 Jun 16;139:37-43
  • Madsen MK, Mc Mahon B, Andersen SB, Siebner HR, Knudsen GM, Fisher PM. Threat-related amygdala functional connectivity is associated with 5-HTTLPR genotype and neuroticism. Soc Cogn Affect Neurosci. 2016 Jan;11(1):140-9
  • Mandeville JB, Sander CY, Wey HY, Hooker JM, Hansen HD, Svarer C, Knudsen GM, Rosen BR. A regularized full reference tissue model for PET neuroreceptor mapping. Neuroimage. 2016 Jun 27;139:405-414
  • Mc Mahon B, Andersen SB, Madsen MK, Hjordt LV, Hageman I, Dam H, Svarer C, da Cunha-Bang S, Baaré W, Madsen J, Hasholt L, Holst K, Frokjaer VG, Knudsen GM. Seasonal difference in brain serotonin transporter binding predicts symptom severity in patients with seasonal affective disorder. Brain. 2016 May;139(Pt 5):1605-14
  • Miskowiak KW, Vinberg M, Glerup L, Paulson OB, Knudsen GM, Ehrenreich H, Harmer CJ, Kessing LV, Siebner HR, Macoveanu J. Neural correlates of improved executive function following erythropoietin treatment in mood disorders. Psychol Med. 2016 Jun;46(8):1679-91
  • Miskowiak KW, Macoveanu J, Vinberg M, Assentoft E, Randers L, Harmer CJ, Ehrenreich H, Paulson OB, Knudsen GM, Siebner HR, Kessing LV. Effects of erythropoietin on memory-relevant neurocircuitry activity and recall in mood disorders. Acta Psychiatr Scand. 2016 Sep;134(3):249-59
  • Nørbak-Emig H, Ebdrup BH, Fagerlund B, Svarer C, Rasmussen H, Friberg L, Allerup PN, Rostrup E, Pinborg LH, Glenthøj BY. Frontal D2/3 receptor availability in schizophrenia patients before and after their first antipsychotic treatment: Relation to cognitive functions and psychopathology. Int J Neuropsychopharmacol. 2016 Apr 29;19(5)
  • Palner M, Beinat C, Banister S, Zanderigo F, Park JH, Shen B, Hjoernevik T, Jung JH, Lee BC, Kim SE, Fung L, Chin FT. Effects of common anesthetic agents on [18F]flumazenil binding to the GABAA Receptor. EJNMMI Res. 2016 Dec;6(1):80
  • Petersen IN, Villadsen J, Hansen HD, Jensen AA, Lehel S, Gillings N, Herth MM, Knudsen GM, Kristensen JL. Convergent 18F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands. Bioorg Med Chem. 2016 Nov 1;24(21):5353-5356
  • Rasmussen H, Frokjaer VG, Hilker RW, Madsen J, Anhøj S, Oranje B, Pinborg LH, Glenthøj B, Knudsen GM. Low frontal serotonin 2A receptor binding is a state marker for schizophrenia?  Eur Neuropsychopharmacol. 2016 Jul;26(7):1248-50
  • Rötering S, Scheunemann M, Günther R, Löser R, Hiller A, Peters D, Brust P, Fischer S, Steinbach J. Tos-Nos-Mos: Synthesis of different aryl sulfonate precursors for the radiosynthesis of the alpha7 nicotinic acetylcholine receptor radioligand [18F]NS14490. Appl Radiat Isot. 2016 Apr 28;114:57-62
  • Salaga M, Blomster LV, Piechota-Polańczyk A, Zielińska M, Jacenik D, Cygankiewicz AI, Krajewska WM, Mikkelsen JD, Fichna J. Encenicline, an α7 Nicotinic Acetylcholine Receptor Partial Agonist, Reduces Immune Cell Infiltration in the Colon and Improves Experimental Colitis in Mice. J Pharmacol Exp Ther. 2016 Jan;356(1):157-69
  • Stenbæk DS, Einarsdottir HS, Goregliad-Fjeallingsdal T, Knudsen GM, Frokjaer VG, Hasselbalch SG. Evaluation of acute tryptophan depletion and sham depletion with a gelatin-based collagen peptide protein mixture. Eur Neuropsychopharmacol. 2016 Jan;26(1):147-9
  • Stenbæk DS, Fisher PM, Budtz-Jørgensen E, Pinborg A, Hjordt LV, Jensen PS, Knudsen GM, Frokjaer VG. Sex hormone manipulation slows reaction time and increases labile mood in healthy women. Psychoneuroendocrinology. 2016 Jun;68:39-46
  • Thomsen MS, Arvaniti M, Jensen MM, Shulepko MA, Dolgikh DA, Pinborg LH, Härtig W, Lyukmanova EN, Mikkelsen JD. Lynx1 and Aβ1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes. Neurobiol Aging. 2016 Oct;46:13-21
  • Vedel AG, Holmgaard F, Rasmussen LS, Paulson OB, Thomsen C, Danielsen ER, Langkilde A, Goetze JP, Lange T, Ravn HB, Nilsson JC. Perfusion Pressure Cerebral Infarct (PPCI) trial - the importance of mean arterial pressure during cardiopulmonary bypass to prevent cerebral complications after cardiac surgery: study protocol for a randomised controlled trial. Trials. 2016 May 17;17(1):247
  • Wu J, Liu Q, Tang P, Mikkelsen JD, Shen J, Whiteaker P, Yakel JL. Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain. Trends Pharmacol Sci. 2016 Jul;37(7):562-74
Books and book chapters
  • Fisher PM, Knudsen GM. Molecular Neuroimaging Genetics. In: Bigos, K.L., Hariri, A.R., Weinberger, D.R. (Eds.) Neuroimaging Genetics – Principles and Practices (2016). Oxford University Press, New York (USA), ISBN: 9780199920211
  • Sørensen PS, Paulson OB, Gjerris F (eds). Nervesystemets sygdomme. Neurologi for fysioterapeuter, ergoterapeuter og neurologisk personale. 4. udg. København: Gads Forlag, 2016:1-552
  • Paulson OB. Kognitive funktioner, sprog og tale. In: Sørensen PS, Paulson OB, Gjerris F (eds). Nervesystemets sygdomme. Neurologi for fysioterapeuter, ergoterapeuter og neurologisk personale. 4. udg. København: Gads Forlag, 2016:39-45
  • Paulson OB. Det motoriske system. In: Sørensen PS, Paulson OB, Gjerris F (eds). Nervesystemets sygdomme. Neurologi for fysioterapeuter, ergoterapeuter og neurologisk personale. 4. udg. København: Gads Forlag, 2016:77-119
  • Paulson OB. Bevidstløshed. In: Sørensen PS, Paulson OB, Gjerris F (eds). Nervesystemets sygdomme. Neurologi for fysioterapeuter, ergoterapeuter og neurologisk personale. 4. udg. København: Gads Forlag, 2016:249-257
  • Paulson OB. Demens og andre neuropsykologiske dysfunktioner. In: Sørensen PS, Paulson OB, Gjerris F (eds). Nervesystemets sygdomme. Neurologi for fysioterapeuter, ergoterapeuter og neurologisk personale. 4. udg. København: Gads Forlag, 2016:271-282
  • Paulson OB. Cerebrovaskulære sygdomme. In: Sørensen PS, Paulson OB, Gjerris F (eds). Nervesystemets sygdomme. Neurologi for fysioterapeuter, ergoterapeuter og neurologisk personale. 4. udg. København: Gads Forlag, 2016:329-355
  • Paulson OB. Neurodegenerative og motoriske neuronsygdomme. In: Sørensen PS, Paulson OB, Gjerris F (eds). Nervesystemets sygdomme. Neurologi for fysioterapeuter, ergoterapeuter og neurologisk personale. 4. udg. København: Gads Forlag, 2016:375-379
  • Paulson OB. Infektioner I nervesystemet. In: Sørensen PS, Paulson OB, Gjerris F (eds). Nervesystemets sygdomme. Neurologi for fysioterapeuter, ergoterapeuter og neurologisk personale. 4. udg. København: Gads Forlag, 2016:439-451
  • Paulson OB. Demensgivende sygdomme. In: Sørensen PS, Paulson OB, Gjerris F (eds). Nervesystemets sygdomme. Neurologi for fysioterapeuter, ergoterapeuter og neurologisk personale. 4. udg. København: Gads Forlag, 2016:453-459
  • Paulson OB. Neurologiske komplikationer til metaboliske og endokrine sygdomme. In: Sørensen PS, Paulson OB, Gjerris F (eds). Nervesystemets sygdomme. Neurologi for fysioterapeuter, ergoterapeuter og neurologisk personale. 4. udg. København: Gads Forlag, 2016:527-531
  • Paulson OB. Intoksikationer og ernæringsdeficit. In: Sørensen PS, Paulson OB, Gjerris F (eds). Nervesystemets sygdomme. Neurologi for fysioterapeuter, ergoterapeuter og neurologisk personale. 4. udg. København: Gads Forlag, 2016:533-537


Original publications in peer-reviewed journals (43)
  • Andersen VL, Hansen HD, Herth MM, Dyssegaard A, Knudsen GM, Kristensen JL. (11)C-labeling and preliminary evaluation of pimavanserin as a 5-HT2A receptor PET-radioligand. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1053-6
  • Asghar Butt S, Søgaard LV, Ardenkjaer-Larsen JH, Lauritzen MH, Engelholm LH, Paulson OB, Mirza O, Holck S, Magnusson P, Akeson P. Monitoring mammary tumor progression and effect of tamoxifen treatment in MMTV-PymT using MRI and magnetic resonance spectroscopy with hyperpolarized [1-13 C]pyruvate. Magn Reson Med. 2015 Jan;73(1):51-8
  • Beliveau V, Svarer C, Frokjaer VG, Knudsen GM, Greve DN, Fisher PM. Functional connectivity of the dorsal and median raphe nuclei at rest. Neuroimage. 2015 Aug 1;116:187-95
  • Bertelsen B, Oranje B, Melchior L, Fagerlund B, Werge TM, Mikkelsen JD, Tümer Z, Glenthøj BY. Association Study of CHRNA7 Promoter Variants with Sensory and Sensorimotor Gating in Schizophrenia Patients and Healthy Controls: A Danish Case-Control Study. Neuromolecular Med. 2015 Dec;17(4):423-30
  • Blaabjerg M, Mærsk-Møller CC, Kondziella D, Somnier F, Celicanin M, Andersen H, Bach FW, Pinborg LH. Workup and treatment of autoimmune encephalitis. Ugeskr Laeger. 2015 Nov 2;177(45)
  • Boutin H, Pinborg LH. TSPO imaging in stroke: from animal models to human subjects. Clin Transl Imaging. 2015 Dec;3(6):423-35
  • Bruun M, Hjermind LE, Thomsen C, Danielsen E, Thomsen LL, Pinborg LH, Khabbazbavani N, Nielsen JE. Familial hemiplegic migraine type 1 associated with parkinsonism: a case report. Case Rep Neurol. 2015 Apr 14;7(1):84-9
  • Fisher PM, Holst KK, Adamsen D, Klein AB, Frokjaer VG, Jensen PS, Svarer C, Gillings N, Baare WFC, Mikkelsen JD, Knudsen GM. BDNF val66met and 5-HTTLPR polymorphisms predict a human in vivo marker for brain serotonin levels. Hum Brain Mapp. 2015 Jan;36(1):313-23
  • Fisher PM, Haahr ME, Jensen CG, Frokjaer VG, Siebner HR, Knudsen GM. Fluctuations in [11C]SB207145 PET binding associated with change in threat-related amygdala reactivity in humans. Neuropsychopharmacology. 2015 May;40(6):1510-8
  • Fisher PM, Grady CL, Madsen MK, Strother SC, Knudsen GM. 5-HTTLPR differentially predicts brain network responses to emotional faces. Hum Brain Mapp. 2015 Jul;36(7):2842-51
  • Frimer NA, Overgaard A, Lie MEK, Mikkelsen JD, Frokjaer VG. Ovariectomy drives asynchronous changes in serotonin receptor 2A and transporter availability in rats. J Steroids Horm Sci. 2015 Nov; 6: 161
  • Frokjaer VG, Pinborg A, Holst KK, Overgaard A, Henningsson S, Heede M, Larsen EC, Jensen PS, Agn M, Nielsen AP, Stenbæk DS, da Cunha-Bang S, Lehel S, Siebner HR, Mikkelsen JD, Svarer C, Knudsen GM. Role of Serotonin Transporter Changes in Depressive Responses to Sex-Steroid Hormone Manipulation: A Positron Emission Tomography Study. Biol Psychiatry. 2015 Oct 15;78(8):534-43
  • Ganz M, Greve DN, Fischl B, Konukoglu E, for the Alzheimer’s Disease Neuroimaging Initiative. Relevant Feature Set Estimation with a Knock-out Strategy and Random Forests. NeuroImage. 2015 Aug 10;122:131-148
  • Hansen HD, Andersen VL, Lehel S, Magnussen JH, Dyssegaard A, Stroth N, Kristensen JL, Knudsen GM, Herth MM. Labeling and preliminary in vivo evaluation of the 5-HT7 receptor selective agonist [(11)C]E-55888. Bioorg Med Chem Lett. 2015 May 1;25(9):1901-4
  • Henningsson S, Madsen KH, Pinborg A, Heede M, Knudsen GM, Siebner HR, Frokjaer VG. Role of emotional processing in depressive responses to sex-hormone manipulation: a pharmacological fMRI study. Transl Psychiatry. 2015 Dec 1;5:e688
  • Herth MM, Andersen VL, Hansen HD, Stroth N, Volk B, Lehel S, Dyssegaard A, Ettrup A, Svenningsson P, Knudsen GM, Kristensen JL. Evaluation of 3-Ethyl-3-(phenylpiperazinylbutyl)oxindoles as PET Ligands for the Serotonin 5-HT7 Receptor: Synthesis, Pharmacology, Radiolabeling, and in Vivo Brain Imaging in Pigs. J Med Chem. 2015 Apr 23;58(8):3631-6
  • Herth M, Knudsen GM. Current Radiosynthesis Strategies for 5-HT2A Receptor PET Tracers. J Labelled Comp Radiopharm. 2015 Jun 15;58(7):265-73
  • Holm SK, Vestergaard M, Madsen KS, Baaré WF, Hammer TB, Born AP, Siebner HR, Paulson OB, Uldall PV. Children and adolescents previously treated with glucocorticoids display lower verbal intellectual abilities. Acta Paediatr. 2015 Aug;104(8):784-91
  • Haahr ME, Hansen DL, Fisher PM, Svarer C, Stenbæk D, Madsen K, Madsen J, Holst JJ, Baaré WF, Hojgaard L, Almdahl T, Knudsen GM. Central 5-HT neurotransmission modulates weight loss following gastric bypass surgery in obese individuals. J Neurosci. 2015 Apr 8;35(14):5884-9
  • Jansen WJ, Ossenkoppele R, Knol DL, Tijms BM, Scheltens P, Verhey FR, Visser PJ; Amyloid Biomarker Study Group. Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis. JAMA. 2015 May 19;313(19):1924-38
  • Jensen CG, Lansner J, Petersen A, Vangkilde SA, Ringkøbing SP, Frokjaer VG, Adamsen D, Knudsen GM, Denninger JW, Hasselbalch SG. Open and Calm--a randomized controlled trial evaluating a public stress reduction program in Denmark. BMC Public Health. 2015 Dec 16;15:1245
  • Jensen MM, Arvaniti M, Mikkelsen JD, Michalski D, Pinborg LH, Härtig W, Thomsen MS. Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease. Neurobiol Aging. 2015 Apr;36(4):1629-38
  • Jensen P, Kondziella D, Thomsen G, Dyssegaard A, Svarer C, Pinborg LH. Anti-NMDAR encephalitis: demonstration of neuroinflammation and the effect of immunotherapy. Neurology. 2015 Feb 24;84(8):859
  • Jensen P, Feng L, Law I, Svarer C, Knudsen GM, Mikkelsen JD, de Nijs R, Larsen VA, Dyssegaard A, Thomsen GK, Fischer W, Guilloteau D, Pinborg LH. TSPO imaging in glioblastoma multiforme: A direct comparison between 123I-CLINDE SPECT, 18F-FET PET and gadolinium-enhanced MRI. J Nucl Med. 2015 Sep;56(9):1386-90
  • Jensen P, Meden P, Knudsen LV, Knudsen GM, Thomsen C, Feng L, Pinborg LH. [Golf handicap score is a suitable scale for monitoring rehabilitation after apoplexia cerebri]. Ugeskr Laeger. 2015 Dec 21;177(52)
  • Jorgensen A, Hansen BS, Stanislaus S, Düring S, Jørgensen MB, Pinborg LH, Kondziella D. Anti-N-methyl-d-aspartate receptor encephalitis is an important differential diagnosis in acute psychiatric disease. Acta Psychiatr Scand. 2015 Jan;131(1):69-70
  • Keller SH, Hansen C, Hansen C, Andersen FL, Ladefoged C, Svarer C, Kjær A, Højgaard L, Law I, Henriksen OM, Hansen AE. Motion correction in simultaneous PET/MR brain imaging using sparsely sampled MR navigators: a clinically feasible tool. EJNMMI Phys. 2015 Dec;2(1):14. Erratum in: EJNMMI Phys. 2015 Dec;2(1):23
  • Ledri M, Sørensen AT, Madsen MG, Christiansen SH, Ledri LN, Cifra A, Bengzon J, Lindberg E, Pinborg LH, Jespersen B, Gøtzsche CR, Woldbye DP, Andersson M, Kokaia M. Differential Effect of Neuropeptides on Excitatory Synaptic Transmission in Human Epileptic Hippocampus. J Neurosci. 2015 Jul 1;35(26):9622-31
  • Lunn TH, Frokjaer VG, Hansen TB, Kristensen PW, Lind T, Kehlet H. Analgesic Effect of Perioperative Escitalopram in High Pain Catastrophizing Patients after Total Knee Arthroplasty: A Randomized, Double-blind, Placebo-controlled Trial. Anesthesiology. 2015 Apr;122(4):884-94
  • Madsen K, Torstensen E, Holst KK, Haahr ME, Knorr U, Frokjaer VG, Brandt-Larsen M, Iversen P, Fisher PM, Knudsen GM. Familial risk for major depression is associated with lower striatal 5-HT4 receptor binding. Int J Neuropsychopharmacol. 2015 Jan 1;18(1)
  • Magnussen JH, Ettrup A, Donat CK, Peters D, Pedersen MHF, Knudsen GM, Mikkelsen JD. Radiosynthesis and in vitro validation of 3H-NS14492 as a novel high affinity alpha7 nicotinic receptor radioligand. Eur J Pharmacol. 2015 May 1; 762;35-41
  • Miskowiak KW, Vinberg M, Macoveanu J, Ehrenreich H, Køster N, Inkster B, Paulson OB, Kessing LV, Skimminge A, Siebner HR. Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders. Biol Psychiatry. 2015 Aug 15;78(4)270-7
  • Nalla AA, Thomsen G, Knudsen GM, Frokjaer VG. The effect of storage conditions on salivary cortisol concentrations using an Enzyme Immuno Assay. Scand J Clin Lab Invest. 2015 Jan;75(1):92-5
  • Nørgaard M, Ganz M, Svarer C, Beliveau V, Fisher PM, Mc Mahon B, Greve DN, Strother SC, Knudsen GM. Estimation of Regional Seasonal Variations in SERT-levels using the FreeSurfer PET pipeline: a reproducibility study. Proceedings of the MICCAI workshop on Computational Methods for Molecular Imaging, 2015
  • Ossenkoppele R, Jansen WJ, Rabinovici GD, Knol DL, van der Flier WM, van Berckel BN, Scheltens P, Visser PJ; Amyloid PET Study Group. Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis. JAMA. 2015 May 19;313(19):1939-49
  • Overgaard A, Axel AM, Lie ME, Hansen HH, Mikkelsen JD. High plasma triglyceride levels strongly correlate with low kisspeptin in the arcuate nucleus of male rats. Endocr Regul. 2015;49(2):51-7
  • Ratner C, Madsen AN, Kristensen LV, Skov LJ, Pedersen KS, Mortensen OH, Knudsen GM, Raun K, Holst B. Impaired oxidative capacity due to decreased CPT1b levels as a contributing factor to fat accumulation in obesity. Am J Physiol Regul Integr Comp Physiol. 2015 Jun 1;308(11):R973-82
  • Spies M, Knudsen GM, Lanzenberger R, Kasper S. Investigating the Serotonin Transporter in Psychiatric Disorders: Insights from PET Imaging. Lancet Psychiatry. 2015 Aug;2(8):743-55
  • Stenbæk DS, Toftager M, Hjordt LV, Jensen PS, Holst KK, Bryndorf T, Holland T, Bogstad J, Pinborg A, Horness P, Frokjaer VG. Mental distress and personality in women undergoing GnRH antagonist versus GnRH agonist protocols for assisted reproductive technology. Hum Reprod. 2015 Jan;30(1):103-10
  • Teodoro R, Scheunemann M, Deuther-Conrad W, Wenzel B, Fasoli FM, Gotti C, Kranz M, Donat CK, Patt M, Hillmer A, Zheng MQ, Peters D, Steinbach J, Sabri O, Huang Y, Brust P. A Promising PET Tracer for Imaging of α7 Nicotinic Acetylcholine Receptors in the Brain: Design, Synthesis, and in Vivo Evaluation of a Dibenzothiophene-Based Radioligand. Molecules. 2015 Oct 9;20(10):18387-18421
  • Thomsen MS, Zwart R, Ursu D, Jensen MM, Pinborg LH, Gilmour G, Wu J, Sher E, Mikkelsen JD. α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties. PLoS One. 2015 Jun 18;10(6):e0130572
  • Visser AK, Ettrup A, Klein AB, van Waarde A, Bosker FJ, Meerlo P, Knudsen GM, de Boer SF. Similar serotonin-2A receptor binding in rats with different coping styles or levels of aggression. Synapse. 2015 Apr;69(4):226-32
  • Wulff S, Pinborg LH, Svarer C, Jensen LT, Nielsen MØ, Allerup P, Bak N, Rasmussen H, Frandsen E, Rostrup E, Glenthøj BY. Striatal D2/3 Binding Potential Values in Drug-Naïve First-Episode Schizophrenia Patients Correlate With Treatment Outcome. Schizophr Bull. 2015 Sep;41(5):1143-52
Books and book chapters
  • Eskesen V, Paulson OB. Bevidsthedssvækkelse og bevidstløshed. In: Paulson OB, Gjerris F, Sørensen PS (Eds). Klinisk neurologi og neurokirurgi. 6. udg. København: FADL, 2015:200-217
  • Knudsen GM, Paulson OB. Hjernens fysiologi. In: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 6. udg. København: FADL, 2015:276-290
  • Knudsen GM, Sørensen PS. Neurologiske komplikationer til systemsygdomme. In: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 6. udg. København: FADL, 2015: 748-69
  • Paulson OB, Sørensen PS. Intoksikationer og ernæringsdeficit. In: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 6. udg. København: FADL, 2015:668-688
  • Paulson OB, Gjerris F. Det motoriske system. In: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 6. udg. København: FADL, 2015:66-112
  • Paulson OB, Sørensen PS. Det sensoriske system. In: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 6. udg. København: FADL, 2015:52-64
  • Paulson OB, Gjerris F. Neurologisk undersøgelse. In: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 6. udg. København: FADL, 2015:14-18


Original publications in peer-reviewed journals (42)
  • Agn M, Svarer C, Frokjaer VG, Greve DN, Knudsen GM, Leemput KV. Improved Resolution and Reliability in Dynamic PET Using Bayesian Regularization of MRTM2. 2014 IEEE International Symposium on Biomedical Imaging
  • Andersen SB, Holst KK, McMahon B, Madsen MK, Møller P, Hageman I, Knudsen GM. Sweet taste sensitivity is influenced by 5-HTTLPR genotype and affected in seasonal affective disorder. Psychiatry Research. 2014 Dec 15;220(1-2):727-9
  • Andersen VL, Hansen HD, Herth MM, Knudsen GM, Kristensen JL. 11C-labeling and preliminary evaluation of vortioxetine as a PET radioligand. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2408-11
  • Bartzen-Sprauer J, Klosen P, Ciofi P, Mikkelsen JD, Simonneaux V. Photoperiodic co-regulation of kisseptin, neurokinin B and dynorphin in the hypothalamus of a seasonal rodent. J Neuroendocrinol. 2014 Aug;26(8):510-20
  • Bertelsen B, Melchior L, Tümer Z, Groth C, Mol Debes N, Skov L, Holst KK, Fagerlund B, Mikkelsen JD. Association of the CHRNA7 promoter variant -86T with Tourette syndrome and comorbid obsessive-compulsive disorder. Psychiatry Res. 2014 Nov 30;219(3):710-1
  • Bortz DM, Jørgensen CV, Mikkelsen JD, Bruno JP. Transient inactivation of the ventral hippocampus in neonatal rats impairs the mesolimbic regulation of prefrontal glutamate release in adulthood. Neuropharmacology. 2014 Sep;84:19-30
  • Brindisi M, Butini S, Franceschini S, Brogi S, Trotta F, Ros S, Cagnotto A, Salmona M, Casagni A, Andreassi M, Saponara S, Gorelli B, Weikop P, Mikkelsen JD, Scheel-Kruger J, Sandager-Nielsen K, Novellino E, Campiani G, Gemma S. Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies. J Med Chem. 2014 Nov 26;57(22):9578-97
  • Comasco E, Frøkjær VG, Poromaa IS. Functional and molecular neuroimaging of menopause and hormone replacement therapy. Frontiers Neuroscience. 2014 Dec 8;8:388
  • Dogonowski AM, Andersen KW, Madsen KH, Sørensen PS, Paulson OB, Blinkenberg M, Siebner HR. Multiple sclerosis impairs regional functional connectivity in the cerebellum. Neuroimage Clin. 2014;4:130-8
  • Dyrby TB, Lundell H, Burke MW, Reislev NL, Paulson OB, Ptito M, Siebner HR. Interpolation of diffusion weighted imaging datasets. Neuroimage. 2014 Dec;103:202-13
  • Ettrup A, da Cunha-Bang S, McMahon B, Lehel S, Dyssegaard A, Skibsted AW, Jørgensen LM, Hansen M, Baandrup AO, Bache S, Svarer C, Kristensen JL, Gillings N, Madsen J, Knudsen GM. Serotonin 2A receptor agonist binding in the human brain with [11C]Cimbi-36. J Cereb Blood Flow Metab. 2014 Jul;34(7):1188-96
  • Feng L, Svarer C, Thomsen G, de Nijs R, Larsen VA, Jensen P, Adamsen D, Dyssegaard A, Fischer W, Meden P, Krieger D, Møller K, Knudsen GM, Pinborg LH. In Vivo Quantification of Cerebral Translocator Protein Binding in Humans Using 6-Chloro-2-(4'-123I-Iodophenyl)-3-(N,N-Diethyl)-Imidazo[1,2-a]Pyridine-3-Acetamide SPECT. J Nucl Med. 2014 Dec;55(12):1966-72
  • Finnema SJ, Stepanov V, Ettrup A, Nakao R, Amini N, Svedberg M, Lehmann C, Hansen M, Knudsen GM, Halldin C. Characterization of [11C]Cimbi-36 as an Agonist PET Radioligand for the 5-HT2A and 5-HT2C Receptors in the Nonhuman Primate Brain. Neuroimage. 2014 Jan;84:342-53
  • Fisher PM, Madsen MK, Mc Mahon B, Holst KK, Andersen SB, Laursen HR, Hasholt LF, Siebner HR, Knudsen GM. Three-week bright-light intervention has dose-related effects on threat-related corticolimbic reactivity and functional coupling. Biol Psychiatry. 2014 Aug 15;76(4):332-9
  • Frokjaer VG, Erritzoe D, Holst KK, Madsen KS, Fisher PM, Madsen J, Svarer C, Knudsen GM. In abstinent MDMA users the cortisol awakening response is off-set but associated with prefrontal serotonin transporter binding as in non-users. Int J Neuropsychopharmacol. 2014 Aug;17(8):1119-28
  • Greve DN, Svarer C, Fisher PM, Feng L, Hansen AE, Baare W, Rosen B, Fischl B, Knudsen GM. Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data. Neuroimage. 2014 May 15;92:225-3
  • Hansen FH, Skjørringe T, Yasmeen S, Arends NV, Sahai MA, Erreger K, Andreassen TF, Holy M, Hamilton PJ, Neergheen V, Karlsborg M, Newman AH, Pope S, Heales SJ, Friberg L, Law I, Pinborg LH, Sitte HH, Loland C, Shi L, Weinstein H, Galli A, Hjermind LE, Møller LB, Gether U. Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. J Clin Invest. 2014 Jul 1;124(7):3107-20
  • Hansen HD, Herth MM, Ettrup A, Andersen VL, Lehel S, Dyssegaard A, Kristensen JL, Knudsen GM. Radiosynthesis and In Vivo Evaluation of Novel Radioligands for PET Imaging of Cerebral 5-HT7 Receptors. J Nucl Med. 2014 Apr;55(4):640-6
  • Hansen HD, Lacivita E, Di Pilato P, Herth MM, Lehel S, Ettrup A, Andersen VL, Dyssegaard A, De Giorgio P, Perrone R, Berardi F, Colabufo NA, Mauro N, Knudsen GM, Leopoldo M. Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor. Eur J Med Chem. 2014 May 22;79:152-63
  • Herth MM, Leth-Petersen S, Lehel S, Hansen M, Knudsen GM, Gillings N, Madsen J, Kristensen JL. Accelerating preclinical PET-screening: reductive amination with [11C]methoxybenzaldehydes. RSC Advances 4 (41), 21347-21350
  • Hesse S, van de Giessen E, Zienteka F, Petroff D, Wintere K, Dickson JC, Tossici-Bolt L, Serah T, Asenbaum S, Darcourt J, Akdemir UO, Knudsen GM, Nobili F, Pagani M, Vanderborght T, Van Laere K,Varrone A,Tatsch K, Sabri O, Booij J. Association of central serotonin transporter availability and body mass index in healthy Europeans. Eur Neuropsychopharmacol. 2014 Aug;24(8):1240-7
  • Haahr ME, Fisher PM, Jensen CG, Frokjaer VG, Mahon BM, Madsen K, Baaré WF, Lehel S, Norremolle A, Rabiner EA, Knudsen GM. Central 5-HT4 receptor binding as biomarker of serotonergic tonus in humans: a [11C]SB207145 PET study. Mol Psychiatry. 2014 Apr;19(4):427-32
  • Jensen CG, Elsass P, Neustrup L, Bihal T, Flyger H, Kay SM, Khan S, Jensen SS, Pedersen A,Würtzen H. What to listen for in the first consultation. Breast cancer patients’ own focus on talking about acceptance-based psychological coping predicts decreased psychological distress and depression. Patient Educ Couns. 2014 Nov;97(2):165-72
  • Jørgensen SR, Andersen MD, Overgaard A, Mikkelsen JD. Changes in RFamide-related peptide-1 (RFRP-1)-immunoreactivity during postnatal development and the estrous cycle. Endocrinology. 2014 Nov;155(11):4402-10
  • Klein AB, Ultved L, Adamsen D, Santini MA, Tobeña A, Fernandez-Teruel A, Flores P, Moreno M, Cardona D, Knudsen GM, Aznar S, Mikkelsen JD. 5-HT2A and mGlu2 receptor binding levels are related to differences in impulsive behavior in the Roman Low- (RLA) and High- (RHA) avoidance rat strains. Neuroscience. 2014 Mar 28;263:36-45
  • Koch W, Unterrainer M, Xiong G, Bartenstein P, Diemling M, Varrone A, Dickson JC, Tossici-Bolt L, Sera T, Asenbaum S, Booij J, Kapucu OL, Kluge A, Ziebell M, Darcourt J, Nobili F, Pagani M, Hesse S, Vander Borght T, Van Laere K, Tatsch K, la Fougère C. Extrastriatal binding of [(123)I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls. Eur J Nucl Med Mol Imaging. 2014 Oct;41(10):1938-46
  • Lacivita E, Niso M, Hansen HD, Di Pilato P, Herth MM, Lehel S, Ettrup A, Montenegro L, Perrone R, Berardi F, Colabufo NA, Leopoldo M, Knudsen GM. Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT7 receptor. Bioorg Med Chem. 2014 Mar 1;22(5):1736-50
  • Macoveanu J, Knorr U, Søndergaard MG, Jørgensen A, Fauerholdt-Jepsen M, Paulson OB, Knudsen GM, Siebner HR, Kessing LV. Altered reward processing in the orbitofrontal cortex and hippocampus in healthy first-degree relatives of patients with depression. Psychol Med. 2014 Apr;44(6):1183-95
  • Macoveanu J, Fisher PM, Haahr ME, Frokjaer VG, Knudsen GM, Siebner HR. Effects of selective serotonin reuptake inhibition on neural activity related to risky decisions and monetary rewards in healthy males. Neuroimage. 2014 Oct;99:434-42
  • Overgaard A, Ruiz-Pino F, Castellano JM, Tena-Sempere M and Mikkelsen JD. Disparate changes in kisspeptin and neurokinin B expression in the arcuate nucleus following sex steroid manipulation reveal differential regulation of the two KNDy peptides in rats. Endocrinology. 2014 Oct;155(10):3945-55
  • Paulson OB, Hossmann KA, Ingvar M, Sokoloff L. In memoriam: Bo K Siesjö, 1930-2013. J Cereb Blood Flow Metab. 2014;34(1):1-1
  • Pedersen SF, Ludvigsen TP, Johannesen HH, Löfgren J, Ripa RS, Hansen AE, Ettrup AJ, Christoffersen BØ, Pedersen HD, Olsen LH, Højgaard L, Kjær A. Feasibility of simultaneous PET/MR in diet-induced atherosclerotic minipig: a pilot study for translational imaging. Am J Nucl Med Mol Imaging. 2014 Aug 15;4(5):448-58
  • Pyndt Jørgensen B, Hansen JT, Krych L, Larsen C, Klein AB, Nielsen DS, Josefsen K, Hansen AK, Sørensen DB. A Possible Link between Food and Mood: Dietary Impact on Gut Microbiota and Behavior in BALB/c Mice. PLoS One. 2014 Aug 18;9(8):e103398
  • Rasmussen H, Ebdrup BH, Oranje B, Pinborg LH, Knudsen GM, Glenthøj B. Neocortical serotonin2A receptor binding predicts quetiapine associated weight gain in antipsychotic-naive first-episode schizophrenia patients. Int J Neuropsychopharmacol. 2014 Nov;17(11):1729-36
  • Santini MA, Balu DT, Puhl MD, Hill-Smith TE, Berg AR, Lucki I, Mikkelsen JD, Coyle JT. D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT2A receptor agonist DOI. Behav Brain Res. 2014 Feb 1;259:242
  • Sigurdsson ST, Paulson OB, Høj Nielsen A, Strandgaard S. Bradykinin antagonist counteracts the acute effect of both angiotensin-converting enzyme inhibition and of angiotensin receptor blockade on the lower limit of autoregulation of cerebral blood flow. J Cereb Blood Flow Metab. 2014 Mar;34(3):467-71
  • Stenbæk DS, Jensen CG, Holst KK, Mortensen EL, Knudsen GM, Frokjaer VG. Does Harm Avoidance mediate effects of recollected parental bonding on mental distress in adulthood? Compr Psychiatry. 2014 May;55(4):1007-14
  • Stenbæk DS, Hjordt LV, Haahr ME, Worm D, Hansen DL, Mortensen EL, Knudsen GM. Personality characteristics in surgery seeking and non-surgery seeking obese individuals compared to non-obese controls. Eating Behaviors. 2014 Aug 28;15(4):595-598
  • Thomsen MS, Cinar B, Jensen MM, Lyukmanova EN, Shulepko MA, Tsetlin V, Klein AB, Mikkelsen, JD. Expression of the Ly-6 family proteins Lynx1 and Ly6H in the rat brain is compartmentalized, cell-type specific, and developmentally regulated. Brain Struct Funct. 2014 Nov;219(6):1923-34
  • Visser AKD, Meerlo P, Ettrup A, Knudsen GM, Bosker FJ, den Boer JA, Dierckx RAJO, van Waarde A. Acute social defeat does not alter cerebral 5-HT2A receptor binding in male Wistar rats. Synapse 2014 Sep;68(9):379-86
  • Wey HY, Catana C, Hooker JM, Dougherty DD, Knudsen GM, Wang DJ, Chonde DB, Rosen BR, Gollub RL, Kong J. Simultaneous fMRI-PET of the Opioidergic Pain System in Human Brain. Neuroimage. 2014 Nov 15;102 Pt 2:275-82
  • Wu X, Hanson LG, Skimminge A, Sorensen PS, Paulson OB, Mathiesen HK, Blinkenberg M. Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis. Neurol Res. 2014 Aug;36(8):701-8
Books and book chapters
  • Frøkjær VG. Molecular Imaging of Depressive Disorders. In: Dierckx R.A.J.O., Otte A., de Vries E.F.J., van Waarde A., den Boer J.A. (Eds.) PET and SPECT in Psychiatry (2014). Springer, New York (USA), ISBN: 9783642403835
  • Knudsen GM, Hasselbalch SG. Imaging of the Serotonin System: Radiotracers and Applications in Memory Disorders. In: Dierckx, R.A.J.O., Otte, A., de Vries, E.F.J., van Waarde, A., Luiten, P.G.M. (Eds.) PET and SPECT of Neurobiological Systems (2014). Springer, New York (USA), ISBN: 9783642420139


Original publications in peer-reviewed journals (57)
  • Allen M, Smallwood J, Christensen J, Gramm D, Rasmussen B, Jensen CG, Roepstorff A, Lutz A. The balanced mind: the variability of task-unrelated thoughts predicts error monitoring. Front Hum Neurosci. 2013 Nov 7;7:743
  • Andersen VL, Herth MM, Lehel S, Knudsen GM, Kristensen JL. Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl-11C-methanes. Tetrahedron Letters. 2013 Jan;54(3):213-6
  • Beniczky S, Lantz G, Rosenzweig I, Åkeson P, Pedersen B, Pinborg LH, Ziebell M, Jespersen B, Fuglsang-Frederiksen A. Source localization of rhythmic ictal EEG activity: a study of diagnostic accuracy following STARD criteria. Epilepsia. 2013 Oct;54(10):1743-52
  • Bortz DM, Mikkelsen JD, Bruno JP. Localized infusions of the partial alpha 7 nicotinic receptor agonist SSR180711 evoke rapid and transient increases in prefrontal glutamate release. Neuroscience. 2013 Dec 26;255:55-67
  • Broberg BV, Madsen KH, Plath N, Olsen CK, Glenthøj BY, Paulson OB, Bjelke B, Søgaard LV. A schizophrenia rat model induced by early postnatal phencyclidine treatment and characterized by Magnetic Resonance Imaging. Behavioural Brain Research. 2013 Aug 1;250:1-8
  • Christensen DZ, Thomsen MS, Mikkelsen JD. Reduced basal and novelty-induced levels of Activity-regulated cytoskeleton protein (Arc) mRNA in the cerebral cortex and hippocampus of APPswe/PS1dE9 transgenic mice. Neurochem Int. 2013 Jul;63(1):54-60
  • Clemmensen C, Smajilovic S, Madsen AN, Klein AB, Holst B, Brauner-Osborne H. Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice. J Endocrinol. 2013 Apr 15;217(2):151-60.
  • da Cunha-Bang S, Stenbæk DS, Holst K, Licht CL, Jensen PS, Frokjaer VG, Mortensen EL, Knudsen GM. Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals. Psychiatry Res. 2013 May 30;212(2):125-31
  • Dogonowski AM, Siebner HR, Sørensen PS, Wu X, Biswal B, Paulson OB, Dyrby TB, Skimminge A, Blinkenberg M, Madsen KH. Expanded functional coupling of subcortical nuclei with the motor resting-state network in multiple sclerosis. Mult Scler. 2013 Apr;19(5):559-66
  • Dogonowski AM, Siebner HR, Soelberg Sørensen P, Paulson OB, Dyrby TB, Blinkenberg M, Madsen KH. Resting-state connectivity of pre-motor cortex reflects disability in multiple sclerosis. Acta Neurol Scand. 2013 Nov;128(5):328-35
  • Elfving B, Christensen T, Ratner C, Wienecke J, Klein AB. Transient activation of mTOR following forced treadmill exercise in rats. Synapse. 2013 Sep;67(9):620-5
  • Ettrup A, Holm S, Hansen M, Wasim M, Santini M, Palner M, Madsen J, Svarer C, Kristensen JL, and Knudsen GM. Preclinical safety assessment of the 5-HT2A receptor agonist PET radioligand [11C]Cimbi-36. Molecular Imaging and Biology. 2013 Aug;15(4):376-83
  • Fagerlund B, Pinborg LH, Mortensen EL, Friberg L, Baaré WF, Gade A, Svarer C, Glenthøj BY. Relationship of frontal D2/3 binding potentials to cognition: a study of antipsychotic-naive schizophrenia patients. Int J Neuropsychopharmacol. 2013 Feb;16(1):23-36
  • Fisher PM, Hariri AR. Identifying serotonergic mechanisms underlying the corticolimbic response to threat in humans. Philos Trans R Soc Lond B Biol Sci. 2013 Feb 25;368(1615):20120192
  • Frokjaer VG, Erritzoe D, Jensen PS, Madsen J, Baaré W, Knudsen GM. Prefrontal serotonin transporter availability is positively associated with the cortisol awakening response. European Neuropsychopharmacology. 2013 Apr;23(4):285-94
  • Grady CL, Siebner HR, Hornboll B, Macoveanu J, Paulson OB, Knudsen GM. Acute pharmacologically induced shifts in serotonin availability abolish emotion-selective responses to negative face emotions in distinct brain networks. Eur Neuropsychopharmacol. 2013 May;23(5):368-78
  • Hansen HD, Ettrup A, Herth MM, Dyssegaard A, Ratner C, Gillings N, Knudsen GM. Direct comparison of [18F]MH.MZ and [18F]Altanserin for 5-HT2A molecular imaging with PET. Synapse. 2013 Jun;67(6):328-37
  • Hansen HH, Jensen MM, Overgaard A, Weikop P, Mikkelsen JD. Tesofensine induces appetite suppression and weight loss with reversal of low forebrain dopamine levels in the diet-induced obese rat. Pharmacol Biochem Behav. 2013 Sep;110:265-71
  • Hasselbalch BJ, Knorr U, Hasselbalch SG, Gade A, Kessing LV. The cumulative load of depressive illness is associated with cognitive function in the remitted state of unipolar depressive disorder. Eur Psychiatry. 2013 Aug;28(6):349-55
  • Herth MM, Andersen VL, Lehel S, Madsen J, Knudsen GM, Kristensen JL. Development of a 11C-labeled tetrazine for rapid tetrazine-trans-cyclooctene ligation. Chem Commun (Camb). 2013 May 8;49(36):3805-7
  • Holst KK, Budtz-Joergensen E. Linear Latent Variable Models: The lava-package. Computational Statistics. 2013;28(4):1385-1452
  • Hornbøll B, Macoveanu J, Rowe J, Elliott R, Paulson OB, Siebner HR, Knudsen GM. Acute serotonin 2A receptor blocking alters the processing of fearful faces in the orbitofrontal cortex and amygdala. J Psychopharmacol. 2013 Oct;27(10):903-14
  • Haagensen AM, Klein AB, Ettrup A, Matthews LR, Sørensen DB. Cognitive performance of göttingen minipigs is affected by diet in a spatial hole-board discrimination test. PLoS One. 2013 Nov 5;8(11):e79429
  • Haahr ME, Fisher PM, Holst KK, Madsen K, Jensen CG, Marner L, Lehel S, Baaré W, Knudsen GM, Hasselbalch SG. The 5-HT4 receptor levels in hippocampus correlates inversely with memory test performance in humans. Human brain mapping. 2013 Nov;34(11):3066-74
  • Janati A, Talbi R, Klosen P, Mikkelsen JD, Magoul R, Simonneaux V, El Ouezzani S. Distribution and seasonal variation in hypothalamic RF-amide peptides in a semi-desert rodent, the jerboa. J Neuroendocrinol. 2013 Apr;25(4):402-11
  • Jørgensen CV, Jacobsen JP, Caron MG, Klein AB, Knudsen GM, Mikkelsen JD. Cerebral 5-HT2A receptor binding, but not mGluR2, is increased in tryptophan hydroxylase 2 decrease-of-function mice. Neurosci Lett. 2013 Oct 25;555:118-22
  • Jørgensen CV, Klein AB, El-Sayed M, Knudsen GM, Mikkelsen JD. Metabotropic glutamate receptor 2 and corticotrophin-releasing factor receptor-1 gene expression is differently regulated by BDNF in rat primary cortical neurons. Synapse. 2013 Nov;67(11):794-800
  • Kalbitzer J, Kalbitzer U, Knudsen GM, Cumming P, Heinz A. How the cerebral serotonin homeostasis predicts environmental changes: a model to explain seasonal changes of brain 5-HTT as intermediate phenotype of the 5-HTTLPR. Psychopharmacology (Berl). 2013 Dec;230(3):333-43
  • Keller SH, Svarer C, Sibomana M. Attenuation correction for the HRRT PET-scanner using transmission scatter correction and total variation regularization. IEEE Trans Med Imaging. 2013 Sep;32(9):1611-21
  • Klein AB, Jennum P, Knudsen S, Gammeltoft S, Mikkelsen JD. Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy. Neuroscience Letters. 2013 Jun 7;544:31-5
  • Knudsen SB, Strandgaard S, Paulson OB. Sekundær prævention af apopleksi med effektiv antihypertensiv behandling. Ugeskr Læger. 2013;175(15):1024
  • Lie ME, Overgaard A, Mikkelsen JD. Effect of a postnatal high-fat diet exposure on puberty onset, estrous cycle regularity, and kisspeptin expression in female rats. Reprod Biol. 2013 Dec;13(4):298-308
  • Lindquist SG, Duno M, Batbayli M, Puschmann A, Braendgaard H, Mardosiene S, Svenstrup K, Pinborg LH, Vestergaard K, Hjermind LE, Stokholm J, Andersen BB, Johannsen P, Nielsen JE. Corticobasal and ataxia syndromes widen the spectrum of C9ORF72 hexanucleotide expansion disease. Clin Genet. 2013 Mar;83(3):279-83
  • Lou AR, Madsen KH, Julian HO, Toft PB, Kjaer TW, Paulson OB, Prause JU, Siebner HR. Postoperative increase in grey matter volume in visual cortex after unilateral cataract surgery. Acta Ophthalmol. 2013 Feb;91(1):58-65.
  • Lund H, Krakauer M, Skimminge A, Sellebjerg F, Garde E, Siebner HR, Paulson OB, Hesse D, Hanson LG. Blood-brain barrier permeability of normal appearing white matter in relapsing-remitting multiple sclerosis. PLoS One. 2013;8(2):e56375
  • Macoveanu J, Hornboll B, Elliott R, Erritzoe D, Paulson OB, Siebner H, Knudsen GM, Rowe JB. Serotonin 2A receptors, citalopram and tryptophan-depletion: a multimodal imaging study of their interactions during response inhibition. Neuropsychpharm. 2013 May;38(6):996-1005
  • Macoveanu J, Rowe JB, Hornboll B, Elliott R, Paulson OB, Knudsen GM, Siebner HR. Serotonin 2A receptors contribute to the regulation of risk-averse decisions. Neuroimage. 2013 Dec;83:35-44
  • Macoveanu J, Rowe JB, Hornboll B, Elliott R, Paulson OB, Knudsen GM, Siebner HR. Playing it safe but losing anyway-Serotonergic signaling of negative outcomes in dorsomedial prefrontal cortex in the context of risk-aversion. Eur Neuropsychopharmacol. 2013 Aug;23(8):919-30
  • Melchior L, Bertelsen B, Debes NM, Groth C, Skov L, Mikkelsen JD, Brøndum-Nielsen K, Tümer Z. Microduplication of 15q13.3 and Xq21.31 in a family with tourette syndrome and comorbidities. Am J Med Genet B Neuropsychiatr Genet. 2013 Dec;162(8):825-31
  • Menezes MM, Santini MA, Benvenga MJ, Marek GJ, Merchant KM, Mikkelsen JD, Svensson KA. The mGlu2/3 Receptor Agonists LY354740 and LY379268 Differentially Regulate Restraint-Stress-Induced Expression of c-Fos in Rat Cerebral Cortex. Neuroscience Journal, vol. 2013, Article ID 736439, 8 pages, 2013. doi:10.1155/2013/736439
  • Mohammadi D. INMiND: getting to the bottom of neuroinflammation. Lancet Neurol. 2013 Dec;12(12):1135-6
  • Nobili F, Naseri M, De Carli F, Asenbaum S, Booij J, Darcourt J, Ell P, Kapucu O, Kemp P, Svarer C, Morbelli S, Pagani M, Sabri O, Tatsch K, Tossici-Bolt L, Sera T, Borght TV, Van Laere K, Varrone A. Automatic semi-quantification of [123I] FP-CIT SPECT scans in healthy volunteers using BASGAN – version 2. Results from the ENC-DAT database. European Journal of Nuclear Medicine and Molecular Imaging. 2013 Apr;40(4):565-73
  • Overgaard A, Holst KK, Mandrup K, Boberg J, Christiansen S, Jacobsen PR, Hass U, Mikkelsen JD. The effect of perinatal exposure to ethinyl oestradiol or a mixture of endocrine disrupting pesticides on kisspeptin neurons in the rat hypothalamus. NeuroToxicology. 2013 Jul;37:154-62
  • Overgaard A, Tena-Sempere M, Franceschini I, Desroziers E, Simonneaux V, Mikkelsen JD. Comparative Analysis of Kisspeptin-immunoreactivity Reveals Genuine Differences between Rats and Mice. Peptides. 2013 Jul;45:85-90
  • Paterson LM, Kornum B, Nutt D, Pike V, Knudsen GM. 5-HT radioligands for human brain imaging with PET and SPECT. Med Res Rev. 2013 Jan;33(1):54-111
  • Piekarski DJ, Zhao S, Jennings KJ, Iwasa T, Legan SJ, Mikkelsen JD, Tsutsui K, Kriegsfeld LJ. Gonadotropin-inhibitory hormone reduces sexual motivation but not lordosis behavior in female Syrian hamsters (Mesocricetus auratus). Horm Behav. 2013 Aug;64(3):501-10
  • Rasmussen H, Ebdrup BH, Aggernaes B, Lublin H, Oranje B, Pinborg LH, Knudsen GM, Glenthøj B. Norquetiapine and Depressive Symptoms in Initially Antipsychotic-Naive First-Episode Schizophrenia. J Clin Psychopharmacol. 2013 Apr;33(2):266-269
  • Reverte I, Klein AB, Domingo JL, Colomina MT. Long term effects of murine postnatal exposure to decabromodiphenyl ether (BDE-209) on learning and memory are dependent upon APOE polymorphism and age. Neurotoxicol Teratol. 2013 Nov-Dec;40:17-27
  • Risgaard R, Ettrup A, Balle T, Dyssegaard A, Hansen HD, Lehel S, Madsen J, Pedersen H, Püschl A, Badolo L, Bang-Andersen B, Knudsen GM, Kristensen JL. Radiolabelling and PET brain imaging of the α1-adrenoceptor antagonist Lu AE43936. Nuclear Medicine and Biology. 2013 Jan;40(1):135-40
  • Sander CY, Hooker JM, Catana C, Normandin MD, Alpert NM, Knudsen GM, Vanduffel W, Rosen BR, Mandeville JB. Neurovascular coupling to D2/D3 receptor occupancy using simultaneous PET/functional MRI. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11169-74
  • Santini MA, Ratner C, Aznar S, Klein AB, Knudsen GM, Mikkelsen JD. Enhanced prefrontal serotonin 2A receptor signaling in the subchronic PCP mouse model of schizophrenia. Journal of Neuroscience Research. 2013 May;91(5):634-41
  • Söderlund AT, Dickson JC, Prvulovich E, Ben-Haim S, Kemp P, Booij J, Nobili F, Thomsen G, Sabri O, Koulibaly PM, Akdemir UO, Pagani M, van Laere K, Dobrozemsky G, George J, Sera T, Tatsch K, Bomanji J. Value of semiquantitative analysis for clinical reporting of 123I-2-β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane SPECT studies. Journal of Nuclear Medicine. 2013 May;54(5):714-22
  • Thomsen G, Knudsen GM, Jensen PS, Ziebell M, Holst KK, Asenbaum S, Booij J, Darcourt J, Dickson JC, Kapucu ÖL, Nobili F, Sabri O, Sera T, Tatsch K, Tossici-Bolt L, van Laere K, Vanderborght T, Varrone A, Pagani M, Pinborg LH. No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT. EJNMMI Res. 2013 May 20;3(1):39
  • Thomsen G, Ziebell M, Jensen PS, da Cuhna-Bang S, Knudsen GM, Pinborg LH. No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I. Obesity (Silver Spring). 2013 Sep;21(9):1803-6
  • van de Giessen E, Hesse S, Caan MW, Zientek F, Dickson JC, Tossici-Bolt L, Sera T, Asenbaum S, Guignard R, Akdemir UO, Knudsen GM, Nobili F, Pagani M, Vander Borght T, Van Laere K, Varrone A, Tatsch K, Booij J, Sabri O. No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers. Neuroimage. 2013 Jan 1;64:61-7
  • Varrone A, Dickson JC, Tossici-Bolt L, Sera T, Asenbaum S, Booik J, Kapucu OL, Kluge A, Knudsen GM, Koulibaly PM, Nobili F, Pagani M, Sabri O, Vander Borght T, Van Laere K, Tatsch K. European multicentre database of healthy controls for [¹²³I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis. Eur J Nucl Med Mol Imaging. 2013 Jan;40(2):213-27
  • Ziebell M, Andersen BB, Pinborg LH, Knudsen GM, Stockholm J, Thomsen G, Karlsborg M, Høgh P, Mørk ML, Hasselbalch SG. Striatal dopamine transporter binding does not correlate with clinical severity in dementia with Lewy bodies. J Nucl Med. 2013 Jul;54(7):1072-6
Books and book chapters
  • Paulson OB, Henriksen HH, Parving H-H. Professor, Overlæge, Niels A. Lassen – Klinisk fysiolog og hjerneforsker. I: Hansen SH, Permin H, eds. Bispebjerg Hospital 100 år. Mosaikker af et hospitals liv. Eget Forlag 2013:216-21
  • Thage O, Paulson OB. Etablering og tidlig udvikling1913-1975. I: Paulson OB, Thage O, Waldemar G, eds. Neurologi i 100 år. Eget Forlag. 2013:10-19
  • Paulson OB, Sørensen PS. Udviklingen fortsætter.1975 til 1999. I: Paulson OB, Thage O, Waldemar G, eds. Neurologi i 100 år. Eget Forlag. 2013:28-41
  • Paulson OB, Sørensen PS. Neuroonkologi. I: Paulson OB, Thage O, Waldemar G, eds. Neurologi i 100 år. Eget Forlag. 2013:112-115
  • Paulson OB, Knudsen GM. Billeddannelse af hjernen. I: Paulson OB, Thage O, Waldemar G, eds. Neurologi i 100 år. Eget Forlag. 2013:128-133
  • Knudsen GM, Mikkelsen JD, Paulson OB, Svarer C. Klinisk neurobiologi. I: Paulson OB, Thage O, Waldemar G, eds. Neurologi i 100 år. Eget Forlag. 2013:134-143
  • Paulson OB. Professorer og overlæger 1913-2013. I: Paulson OB, Thage O, Waldemar G, eds. Neurologi i 100 år. Eget Forlag. 2013:162-166
  • Paulson OB. Publikationer 1972-2013. I: Paulson OB, Thage O, Waldemar G, eds. Neurologi i 100 år. Eget Forlag. 2013:168-172


Original publications in peer-reviewed journals (44)
  • Absalom N, Eghorn LF, Villumsen IS, Karim N, Bay T, Olsen JV, Knudsen GM, Bräuner-Osborne H, Frølund B, Clausen RP, Chebib M, Wellendorph P. α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13404-9
  • Ancel C, Bentsen AH, Sébert ME, Tena-Sempere M, Mikkelsen JD, Simonneaux V.Stimulatory Effect of RFRP-3 on the Gonadotrophic Axis in the Male Syrian Hamster: The Exception Proves the Rule. Endocrinology. 2012 Mar;153(3):1352-63
  • Balslev D, Siebner HR, Paulson OB, Kassuba T. The cortical eye proprioceptive signal modulates neural activity in higher-order visual cortex as predicted by the variation in visual sensitivity. Neuroimage. 2012 Jul 16;61(4):950-6
  • Blinkenberg M, Akeson P, Sillesen H, Lövgaard S, Sellebjerg F, Paulson OB, Siebner HR, Sørensen PS. Chronic cerebrospinal venous insufficiency and venous stenoses in multiple sclerosis. Acta Neurol Scand. 2012 Dec;126(6):421-7
  • Blinkenberg M, Mathiesen HK, Tscherning T, Jønsson A, Svarer C, Holm S, Sellebjerg F, Paulson OB, Hanson LG, Sorensen PS. Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study. Neurol Res. 2012 Jan;34(1):52-8
  • Clemmensen C, Aznar S, Knudsen GM and Klein AB. The microtubule-associated protein 1A (MAP1A) is an early molecular target of soluble Aβ-peptide Cellular and Molecular. Cell Mol Neurobiol. 2012 May;32(4):561-6
  • Dickson JC, Tossici-Bolt L, Sera T, de Nijs R, Booij J, Bagnara MC, Seese A, Koulibaly PM, Akdemir UO, Jonsson C, Koole M, Raith M, Lonsdale MN, George J, Zito F, Tatsch K. Proposal for the standardisation of multi-centre trials in nuclear medicine imaging: prerequisites for a European 123I-FP-CIT SPECT database. Eur J Nucl Med Mol Imaging. 2012 Jan;39(1):188-97
  • Eiberg H, Hansen L, Korbo L, Nielsen I, Svenstrup K, Bech S, Pinborg L, Friberg L, Hjermind L, Olsen O, Nielsen J. Novel mutation in ATP13A2 widens the spectrum of Kufor-Rakeb syndrome (PARK9).Clin Genet. 2012 Sep;82(3):256-63
  • Fisher PM, Holst KK, Mc Mahon B, Haahr ME, Madsen K, Gillings N,  Baaré WF, Jensen PS,  Knudsen GM. 5-HTTLPR status predictive of neocortical 5-HT4 binding assessed with [11C]SB207145 PET in humans. Neuroimage. 2012 Aug 1;62(1):130-6
  • Fisher PM, Hariri AR. Linking variability in brain chemistry and circuit function through multimodal human neuroimaging. Genes Brain Behav. 2012 Aug;11(6):633-42
  • Gagnon L, Schneider FC, Siebner HR, Paulson OB, Kupers R, Ptito M. Activation of the hippocampal complex during tactile maze solving in congenitally blind subjects. Neuropsychologia. 2012;50:1663-71.
  • Hasselbalch BJ, Knorr U, Bennike B, Hasselbalch SG, Søndergaard MH, Kessing LV. Decreased levels of brain-derived neurotrophic factor in the remitted state of unipolar depressive disorder. Acta Psychiatr Scand. 2012 Sep;126(3):157-64
  • Herth MM, Kramer V, Gillings N, Rösch F, Knudsen GM. Direct radiofluorination of [18F]MH.MZ for 5-HT2A receptor molecular imaging with PET. Journal of Labelled Compounds and Radiopharmaceuticals 2012; 55(9):354-358
  • Herth MM, Hansen HD, Ettrup A, Dyssegaard A, Lehel S, Kristensen J, Knudsen GM. Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging. Bioorganic & Medicinal Chemistry. 2012 July;20(14):4574-81
  • Herth MM, Volk B, Pallagi K, Bech LK, Antoni FA, Knudsen GM, Kristensen JL. Synthesis and in vitro Evaluation of Oxindole Derivatives as Potential Radioligands for 5-HT7 Receptor Imaging with PET. ACS Chemical Neuroscience. 2012 Dec 19;3(12):1002-7
  • Haahr ME, Rasmussen PM, Madsen K, Marner L, Ratner C, Gillings N, Barré WF, Knudsen GM. Obesity is associated with high serotonin 4 receptor availability in the brain reward circuitry. Neuroimage. 2012 Jul 16;61(4):884-8
  • Jacobsen J, Hansen HH, Kiss A, Mikkelsen JD. The α4β2 nicotine acetylcholine selective agonist ispronicline induces c-Fos expression in selective regions of the rat forebrain. Neurosci Lett. 2012 25;515(1):7-11
  • Jennings KA, Licht CL, Bruce A, Lesch KP, Knudsen GM, Sharp T. Genetic variation in 5-hydroxytryptamine transporter expression causes adaptive changes in 5-HT4 receptor levels. Int J Neuropsychopharmacol. 2012 Sep;15(8):1099-107
  • Jensen CG, Vangkilde S, Frokjaer V, Hasselbalch SG. Mindfulness training affects attention-or is it attentional effort? J Exp Psychol Gen. 2012, 141(1):106–123
  • Jensen CG, Parker A. Entangled in the womb? A pilot study on the possible physiological connectedness between identical twins with different embryonic backgrounds. Explore (NY). 2012 Nov;8(6):339-47
  • Keller SH, Sibomana M, Olesen OV, Svarer C, Holm S, Andersen FL, Højgaard L. Methods for Motion Correction Evaluation Using 18F-FDG Human Brain Scans on a High-Resolution PET Scanner. J Nucl Med. 2012 Mar;53(3):495-504
  • Koefoed P, Wolbye DPD, Hansen TVO, Eplov LF, Christiansen SH, Mors O, Kessing LV, Werge T,Kaipio K, Pesonen U, Fahmy T, Mellerup E, Jakobsen KD, Hansen ES, Knudsen GM, Bukh JD, Bock C, Lindberg C, Kristensen AS, Dam H, Nordentoft M,  Als TD, Wang AG, Gether U, Rehfeld JF, Bolwig TG. Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression. Acta Neuropsychiatrica. 2012 April;24(2):81-90
  • Lagerburg V, de Nijs R, Holm S, Svarer C. A comparison of different energy window subtraction methods to correct for scatter and downscatter in I-123 SPECT imaging. Nucl Med Commun. 2012 Jul;33(7):708-18
  • Licht CL, Christoffersen M, Okholm M, Damgaard L, Fink-Jensen A, Knudsen GM, Erritzoe D. Simultaneous polysubstance use among Danish 3,4-methylenedioxymethamphetamine and hallucinogen users: combination patterns and proposed biological bases. Hum Psychopharmacol. 2012 Jul;27(4):352-63
  • Lund H, Jønsson A, Andresen J, Rostrup E, Paulson OB, Sørensen PS. Cognitive deficits in multiple sclerosis: correlations with T2 changes in normal appearing brain tissue. Acta Neurol Scand. 2012 May;125(5):338-44
  • Madsen K, Hasselbalch BJ, Frederiksen KS, Haahr ME, Gade A, Law I, Price JC, Knudsen GM, Kessing LV, Hasselbalch SG. Lack of association between prior depressive episodes and cerebral [11C]PiB binding. Neurobiol Aging. 2012 Oct;33(10):2334-42
  • Madsen KS, Jernigan TL, Iversen P, Frokjaer VG, Mortensen EL, Knudsen GM, Baaré WF. Cortisol awakening response and negative emotionality linked to asymmetry in major limbic fibre bundle architecture. Psychiatry Res. 2012 Jan 30;201(1):63-72
  • Madsen KS, Jernigan TL, Iversen P, Frokjaer VG, Knudsen GM, Siebner HR, Baaré WF. Hypothalamic-pituitary-adrenal axis tonus is associated with hippocampal microstructural asymmetry. Neuroimage. 2012 Oct 15;63(1):95-103
  • Marner L, Frøkjær VG, Kalbitzer J, Lehel S, Madsen K, Baaré WF, Knudsen GM, Hasselbalch SG. Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease. A combined [11C]DASB and [18F]altanserin-PET study. Neurobiol Aging. 2012 Mar;33(3):479-87
  • Marner L. Communication among neurons. Dan Med J. 2012 Apr;59(4):B4427
  • Mikkelsen JD, Jacobsen J, Kiss A. Differential sensitivity to nicotine among hypothalamic magnocellular neurons. Endocr Regul. 2012 Jan;46(1):13-20
  • Mikkelsen JD, Rasmussen MA, Meyer M, Knudsen GM. Reprogrammering af modne celler til neuroner. Ugeskr Laeger. 2012 Mar 19;174(12):786
  • Paulson OB, Kanno I, Reivich M, Sokoloff L. History of International Society for Cerebral Blood Flow and Metabolism. J Cereb Blood Flow Metab. 2012 Jul;32(7):1099-106
  • Paulson O, Bolwig, T. Det værste halsonde – patientens oplevelse, når det går godt og kunne være gået gruelig galt. Kronik. Ugeskr Laeger 2012;174:1628-1629
  • Pinborg LH, Feng L, Haahr ME, Gillings N, Dyssegaard A, Madsen J, Svarer C, Yndgaard S, Kjaer TW, Parsey RV, Hansen HD, Ettrup A, Paulson OB, Knudsen GM. No change in [11C]CUMI-101 binding to 5-HT1A receptors after intravenous citalopram in human. Synapse 2012 Oct;66(10):880-4
  • Ptito M, Matteau I, Wang AZ, Paulson OB, Siebner HR, Kupers R. Crossmodal Recruitment of the Ventral Visual Stream in Congenital Blindness. Neural Plasticity 2012;2012:304045
  • Ramsøy TZ, Liptrot MG, Skimminge A, Lund TE, Sidaros K, Christensen MS, Baaré W, Paulson OB, Jernigan TL, Siebner HR. Healthy aging attenuates task-related specialization in the human medial temporal lobe. Neurobiol Aging. 2012 Sep;33(9):1874-89 
  • Ratner C, Ettrup A, Bueter M, Haahr ME, Compan V, le Roux C, Levin B, Hansen H, Knudsen GM. Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Ygastric bypass. Obesity. 2012 Oct;20(10):2133-41
  • Reverte I, Klein AB, Ratner C, Domingo JL, Columina MT. Behavioral phenotype and BDNF differences related to ApoE isoforms and sex in young transgenic mice. Exp Neurol. 2012 Sep;237(1):116-25
  • Thomsen MS, Mikkelsen JD. The α7 nicotinic acetylcholine receptor complex: one, two or multiple drug targets? Curr Drug Targets. 2012 May;13(5):707-20
  • Thomsen MS, Mikkelsen JD. Type I and II positive allosteric modulators (PAMs) differentially modulate agonist-induced upregulation of alpha7 nicotinic acetylcholine receptors (nAChRs). J Neurochem. 2012 Oct;123(1):73-83
  • Thomsen MS, Mikkelsen JD. The alpha7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-alpha release from microglia. J Neuroimmunol. 2012 Oct 15;251(1-2):65-72
  • Ziebell M, Khalid U, Klein AB, Aznar S, Thomsen G, Jensen P, Knudsen GM. Striatal dopamine transporter binding correlates with serum BDNF levels in patients with striatal dopaminergic neurodegeneration. Neurobiol Aging. 2012 Feb;33(2):428
  • Ziebell M, Andersen BB, Thomsen G, Pinborg LH, Karlsborg M, Hasselbalch SG, Knudsen GM. Predictive value of dopamine transporter SPECT imaging with [123I]PE2I in patients with subtle parkinsonian symptoms. European Journal of Nuclear Medicine and Molecular Imaging. 2012 Feb;39(2):242-50
Books and book chapters
  • Knudsen GM. Blood-brain barrier transport of lactate. In: Neural metabolism in vivo (eds. Choi I-Y, Gruetter R) Advances in Neurobiology (ed Lajtha A), vol. 4. 2012. Springer


Original publications in peer-reviewed journals (35)
  • Ansel L, Bentsen AH, Ancel C, Bolborea M, Klosen P, Mikkelsen JD, Simonneaux V. Peripheral kisspeptin reverses short photoperiod-induced gonadal regression in Syrian hamsters by promoting GNRH release. Reproduction. 2011;142(3):417-25
  • Aznar S, Knudsen GM. Depression and Alzheimer's Disease: Is stress the initiating factor in a common neuropathological cascade? J Alzheimers Dis. 2011;23(2):177-93
  • Castellano JM, Bentsen AH, Sánchez-Garrido MA, Ruiz-Pino F, Romero M, Garcia-Galiano D, Aguilar E, Pinilla L, Diéguez C, Mikkelsen JD, Tena-Sempere M. Early metabolic programming of puberty onset: impact of changes in postnatal feeding and rearing conditions on the timing of puberty and development of the hypothalamic kisspeptin system. Endocrinology. 2011;152(9):3396-408
  • Damsted SK, Born AP, Paulson OB, Uldall P. Exogenous glucocorticoids and adverse cerebral effects in children. Eur J Paediatr Neurol. 2011;15(6):465-77
  • El-Sayed M, Hofman-Bang J, Mikkelsen JD. Effect of brain derived neurotrophic factor on activity regulated cytoskeleton associated protein gene expression in primary frontal cortical neurons. Comparison with NMDA and AMPA. Eur J Pharmacol. 2011; 25;660(2-3):351-7
  • Erritzoe D, Frokjaer VG, Holst KK, Christoffersen M, Johansen SS, Svarer C, Madsen J, Rasmussen PM, Ramsøy T, Jernigan TL, Knudsen GM. In Vivo Imaging of Cerebral Serotonin Transporter and Serotonin2A Receptor Binding in 3,4-Methylenedioxymethamphetamine (MDMA or "Ecstasy") and Hallucinogen Users. Arch Gen Psychiatry. 2011;68(6):562-76
  • Ettrup A, Kornum B, Weikop P, Knudsen GM. An approach for serotonin depletion in pigs: Effects on serotonin receptor binding. Synapse 2011;65(2):136-45
  • Ettrup A, Hansen M, Santini MA, Paine J, Gillings N, Palner M, Lehel S, Herth MM, Madsen J, Kristensen J, Begtrup M, Knudsen GM. Radiosynthesis and in vivo evaluation of a series of substituted (11)C-phenethylamines as 5-HT (2A) agonist PET tracers. Eur J Nucl Med Mol Imaging. 2011;38(4):681-93
  • Ettrup A, Mikkelsen JD, Lehel S, Madsen J, Nielsen EO, Timmermann DB, Peters D and KnudsenGM; [11C]NS14492 as a novel PET radioligand for imaging cerebral α7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements. J Nucl Med. 2011;52(9):1449-56
  • Jennings KA, Licht CL, Bruce A, Lesch KP, Knudsen GM, Sharp T. Genetic variation in 5-hydroxytryptamine transporter expression causes adaptive changes in 5-HT4 receptor levels. The International Journal of Neuropsychopharmacology 2011;16:1-9
  • Jensen MM, Lange SC, Thomsen MS, Hansen HH, Mikkelsen JD. The Pharmacological Effect of KCNQ (Kv7) Positive Modulators on Dopamine Release from Striatal Slices. Basic Clin Pharmacol Toxicol. 2011:339-42
  • Jensen PS, Thomsen G, Ziebell M, deNijs, R, Svarer C, Malik U, Skouboe G, Knudsen GM. Validation of a Method for Accurate and Highly Reproducible Quantification of Brain Dopamine Transporter SPECT Studies. J. Nuclear Medicine and Technology2011;39(4):271-8
  • Klein AB, Williamson R, Santini MA, Clemmensen C, Ettrup A, Rios M, Knudsen GM, Aznar S. Blood BDNF concentrations reflect brain tissue BDNF levels across species. Int J Neuropsychopharmacol. (2011), 14, 347–353
  • Kornum BR, Knudsen GM. Cognitive testing of pigs (Sus scrofa) in translational biobehavioral research. Neurosci Biobehav Rev 2011;35(3):437-51
  • Kupers R, Frokjaer V, Erritzoe D, Naert A, Budtz-Joergensen E, Nielsen FA, Kehlet H, Knudsen GM. Serotonin transporter binding in the hypothalamus correlates negatively with tonic heat pain ratings in healthy subjects: a [11C]DASB PET study. Neuroimage 2011;54(2):1336-43
  • Kupers R, Beaulieu-Lefebvre M, Schneider FC, Kassuba T, Paulson OB, Siebner HR, Ptito M. Neural correlates of olfactory processing in congenital blindness. Neuropsychologia 2011;49(7):2037-44
  • Liu X, Cannon DM, Akula N, Moya PR, Knudsen GM, Arentzen TE, Steele J, Laje G, Drevets WC, McMahon FJ. A non-synonymous polymorphism in galactose mutarotase (GALM) is associated with serotonin transporter binding potential in the human thalamus: results of a genome-wide association study. Molecular Psychiatry 2011; 16, 584–5
  • Lou AR, Madsen KH, Paulson OB, Julian HO, Prause JU, Siebner HR, Kjaer TW. Monocular Visual Deprivation Suppresses Excitability in Adult Human Visual Cortex. Cereb Cortex. 2011:2876-82
  • Madsen J, Elfving B, Frøkjær VG, Kornum BR, Thomsen G, Martiny L, Knudsen GM. Synthesis and Biological Evaluation of 125I/123I-Labelled Analogues of Citalopram and Escitalopram as Potential Radioligands for Imaging of the Serotonin Transporter. J. Label Compd. Radiopharm 2011, 54 185–190
  • Madsen K, Haahr M, Marner L, Keller SH, Baaré W, Svarer C, Hasselbalch SG, Knudsen GM. Age and Sex Effects on 5-HT(4) Receptors in the Human Brain – A [11C]SB207145 PET Study. Journal of Cerebral Blood Flow & Metabolism 2011;31(6):1475-81
  • Madsen K, Erritzoe D, Mortensen EL, Gade A, Madsen J, Baaré W, Knudsen GM, Hasselbalch SG. Cognitive Function is Related to Fronto-striatal Serotonin Transporter Levels - A Brain PET Study in Young Healthy Subjects. Psychopharmacology (Berl). 2011;213(2-3):573-81
  • Madsen K, Neumann WJ, Holst K, Marner L, Haarh MT, Lehel S, Knudsen GM, Hasselbalch SG. Cerebral Serotonin 4 receptors and Amyloid-β in Early Alzheimer’s Disease. J Alzheimers Dis. 2011; 1;26(3):457-66
  • Madsen K, Marner L, Haahr M, Gillings N, Knudsen GM. Mass Dose Effects and In Vivo Affinity in Brain PET Receptor Studies – A Study of Cerebral 5-HT4 Receptor Binding with [11C]SB207145. Nuclear medicine and biology 2011;38(8):1085-91
  • Marner L, Knudsen GM, Madsen K, Holm S, Baaré W, Hasselbalch SG. The reduction of Baseline Serotonin 2A Receptors in Mild Cognitive Impairment is stable at Two-year Follow-up. J Alzheimers Dis. 2011;23(3):453-9
  • Palner M, Underwood MD, Kumar DJ, Arango V, Knudsen GM, Mann JJ, Parsey RV. Ex vivo evaluation of the serotonin 1A receptor partial agonist [(3)H]CUMI-101 in awake rats. Synapse. 2011;65(8):715-23
  • Palner M, Kjaerby C, Knudsen GM, Cummings P. Effects of unilateral 6-OHDA lesion on [3H]NPA binding in striatum ex vivo, and vulnerability to amphetamine-evoked dopamine release in rat. Neurochemistry International 58 (2011) 243–247
  • Rasmussen H, Ebdrup BH, Erritzoe D, Aggernaes B, Oranje B, Kalbitzer J, Pinborg LH, Baaré WF, Svarer C, Lublin H, Knudsen GM, Glenthoj B. Serotonin2A receptor blockade and clinical effect in first-episode schizophrenia patients treated with quetiapine. Psychopharmacology (Berl). 2011;213(2-3):583-92
  • Ryberg C, Rostrup E, Paulson OB, Barkhof F, Scheltens P, van Straaten EC, van der Flier WM, Fazekas F, Schmidt R, Ferro JM, Baezner H, Erkinjuntti T, Jokinen H, Wahlund LO, Poggesi A, Pantoni L, Inzitari D, Waldemar G. Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: A 3-year follow-up of the LADIS study cohort. J Neurol Sci. 2011 Aug 15;307(1-2):100-105
  • Salem LC, Hejl AM, Garde E, Leffers AM, Paulson OB, Waldemar G. White matter hyperintensities and prepulse inhibition in a mixed elderly population. Psychiatry Res. 2011 30;194(3):314-8
  • Santini MA, Klein AB, El-Sayed M, Ratner C, Knudsen GM, Mikkelsen JD, Aznar S. Novelty-induced activity-regulated cytoskeletal-associated protein (arc) expression in frontal cortex requires Serotonin 2A receptor activation. Neuroscience 2011, 8;190:251-7
  • Söderman A, Mikkelsen JD, West MJ, Christensen DZ, Jensen MS. Activation of nicotinic α(7) acetylcholine receptor enhances long term potentation in wild type mice but not in APPswe/PS1ΔE9 mice. Neurosci Lett 2011;487(3):325-9
  • Thomsen MS, Weyn A, Mikkelsen JD. Hippocampal α7 Nicotinic Acetylcholine Receptor Levels in Patients with Schizophrenia, Bipolar  Disorder, or Major Depressive Disorder. Bipolar Disorders 2011;13(7-8):701-7
  • Thomsen MS, El-Sayed M, Mikkelsen JD. Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats.PLoS One. 2011; 6(11) :e27014
  • Vestergaard M, Madsen KS, Baaré WF, Skimminge A, Ejersbo LR, Ramsøy TZ, Gerlach C, Akeson P, Paulson OB, Jernigan TL. White Matter Microstructure in Superior Longitudinal Fasciculus Associated with Spatial Working Memory Performance in Children. J Cogn Neurosci. 2011;23(9):2135-46
  • Williams WP 3rd, Jarjisian SG, Mikkelsen JD, Kriegsfeld LJ. Circadian control of kisspeptin and a gated GnRH response mediate the preovulatory luteinizing hormone surge. Endocrinology. 2011 Feb;152(2):595-606


Original publications in peer-reviewed journals (55)
  • Ansel L, Bolborea M, Bentsen AH, Klosen P, Mikkelsen JD, Simonneaux V. Differential regulation of kiss1 expression by melatonin and gonadal hormones in male and female Syrian hamsters. J Biol Rhythms. 2010;25(2):81-91
  • Axel AM, Mikkelsen JD, Hansen HH. Tesofensine, a Novel Triple Monoamine Reuptake Inhibitor, Induces Appetite Suppression by Indirect Stimulation of alpha(1) Adrenoceptor and Dopamine D(1) Receptor Pathways in the Diet-Induced Obese Rat. Neuropsychopharmacology 2010;35(7):1464-76
  • Aznar S, Klein AB, Santini MA, Knudsen GM, Henn F, Gass P, Vollmayr B. Aging and depression vulnerability interaction results in decreased serotonin innervation associated with reduced BDNF levels in hippocampus of rats bred for learned helplessness. Synapse 2010;64(7):561-5
  • Baaré WF, Vinberg M, Knudsen GM, Paulson OB, Langkilde AR, Jernigan TL, Kessing LV. Hippocampal volume changes in healthy subjects at risk of unipolar depression. J Psychiatr Res 2010;44(10):655-62
  • Bentsen AH, Ansel L, Simonneaux V, Tena-Sempere M, Juul A, Mikkelsen JD. Maturation of kisspeptinergic neurons coincides with puberty onset in male rats. Peptides 2010;31(2):275-83
  • Benveniste H, Fowler JS, Rooney WD, Scharf BA, Backus WW, Izrailtyan I, Knudsen GM, Hasselbalch SG, Volkow ND. Cocaine is Pharmacologically Active in the Non-Human Primate Fetal brain. Proc Natl Acad Sci U S A 2010;107(4):1582-7
  • Bundzikova J, Pirnik Z, Zelena D, Mikkelsen JD, Kiss A. The alpha(2)-adrenoceptors do not modify the activity of tyrosine hydroxylase, corticoliberine, and neuropeptide Y producing hypothalamic magnocellular neurons ion the Long Evans and Brattleboro rats. J Physiol Pharmacol 2010;61(4):391-8
  • Castellano JM, Bentsen AH, Romero M, Pineda R, Ruiz-Pino F, Garcia-Galiano D, Sanchez-Garrido MA, Pinilla L, Mikkelsen JD, Tena-Sempere M. Acute inflammation reduces kisspeptin immunoreactivity at the arcuate nucleus and decreases responsiveness to kisspeptin independently of its anorectic effects. Am J Physiol Endocrinol Metab 2010;299(1):E54-61
  • Castellano JM, Bentsen AH, Mikkelsen JD, Tena-Sempere M. Kisspeptins: Bridging energy homeostasis and reproduction. Brain Res 2010;1364:129-38
  • Christensen DZ, Mikkelsen JD, Hansen HH, Thomsen MS. Repeated administration of α7 nicotinic acetylcholine receptor (nAChR) agonists, but not positive allosteric modulators, increases α7 nAChR levels in the brain. J Neurochem 2010;114(4):1205-16
  • de Nijs R, Holm S, Thomsen G, Ziebell M, Svarer C. Experimental determination of the weighting factor for the energy window subtraction-based downscatter correction for I-123 in brain SPECT studies. J Med Phys 2010;35(4):215-22
  • Desroziers E, Mikkelsen J, Simonneaux V, Keller M, Tillet Y, Caraty A, Franceschini I. Mapping of kisspeptin fibres in the brain of the pro-oestrous rat. J Neuroendocrinol. 2010 Oct;22(10):1101-12
  • Ebdrup BH, Glenthøj B, Rasmussen H, Aggernaes B, Langkilde AR, Paulson OB, Lublin H, Skimminge A, Baaré W. Hippocampal and caudate volume reductions in antipsychotic-naive first-episode schizophrenia. J Psychiatry Neurosci 2010;35(2):95-104
  • Erritzøe D, Frøkjær VG, Haahr MT, Kalbitzer J, Svarer C, Holst KK, Hansen DL, Jernigan TL, Lehel S, Knudsen GM. Cerebral serotonin transporter binding is inversely related to body mass index. Neuroimage 2010;52(1):284-9
  • Erritzøe D, Holst K, Frøkjær VG, Licht CL, Kalbitzer J, Nielsen FA, Svarer C, Madsen J, Knudsen G. A Nonlinear Relationship between Cerebral Serotonin Transporter and 5-HT2A Receptor Binding: An In Vivo Molecular Imaging Study in Humans. J Neurosci 2010;30(9):3391-7
  • Ettrup A, Palner M, Gillings N, Santini MA, Hansen M, Kornum BR, Rasmussen LK, Någren K, Madsen J, Begtrup M, Knudsen GM. Radiosynthesis and evaluation of [11C]Cimbi-5 as a 5-HT2A receptor agonist radioligand for PET. J Nucl Med 2010;51(11):1763-70
  • Frøkjær VG, Erritzøe D, Juul A, Nielsen FA, Holst K, Svarer C, Madsen J, Paulson OB, Knudsen GM. Endogenous plasma estradiol in healthy men is positively correlated with cerebral cortical serotonin 2A receptor binding. Psychoneuroendocrinology. 2010;35(9):1311-20
  • Frøkjær VG, Vinberg M, Erritzøe D, Baaré W, Holst KK, Mortensen EL, Arfan H, Madsen J, Jernigan TL, Kessing LV, Knudsen GM. Familial risk for mood disorder and the personality risk factor, neuroticism, interact in their association with frontolimbic serotonin 2A receptor binding. Neuropsychopharmacology 2010;35(5):1129-37
  • Hansen HH, Hansen G, Tang-Christensen M, Larsen PJ, Axel AM, Raben A, Mikkelsen JD. The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: Comparison to sibutramine and rimonabant. Eur J Pharmacol 2010;636(1-3):88-95
  • Holm P, Ettrup A, Klein AB, Santini MA, El-Sayed M, Elvang AB, Stensbøl TB, Mikkelsen JD,  Knudsen GM, Aznar S. Plaque deposition dependent decrease in 5-HT_2A serotonin receptor in APP**swe/PS1dE9 amyloid overexpressing mice. J Alzheimers Dis 2010;1;20(4):1201-13
  • Kalbitzer J, Erritzoe D, Holst KK, Nielsen FA, Marner L, Lehel S, Arentzen T, Jernigan TL, Knudsen GM. Seasonal changes in brain serotonin transporter binding in short serotonin transporter linked polymorphic region-allele carriers but not in long-allele homozygotes. Biol Psychiatry. 2010;67(11):1033-9
  • Kelsen J, Larsen MH, Sørensen JC, Møller A, Frøkiær J, Nielsen S, Nyengaard JR, Mikkelsen JD, Rønn LC. Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools. Exp Transl Stroke Med 2010;6;2:8
  • Kiss A, Bundzikova J, Pirnik Z, Mikkelsen JD. Different antipsychotics elicit different effects on magnocellular oxytocinergic and vasopressinergic neurons as revealed by Fos immunohistochemistry. J Neurosci Res 2010;88(3):677-85
  • Klein AB, Santini MA, Aznar S, Knudsen GM, Rios M. Changes in 5-HT(2A)-mediated behavior and 5-HT(2A)- and 5-HT(1A) receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice. Neuroscience 2010;169(3):1007-16
  • Klein AB, Trajkovska V, Erritzøe D, Haugbøl S, Madsen J, Baaré W, Aznar S, Knudsen GM. Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels. J Cereb Blood Flow Metab 2010;30(11):e1-7
  • Knudsen S, Mikkelsen JD, Bang B, Gammeltoft S. og Jennum PJ: Intravenous immunoglobulin treatment and screening for hypocretin neuron-specific autoantibodies in recent onset childhood narcolepsy with cataplexy: Neuropediatrics. 2010;41(5), 217-22
  • Koefoed P, Woldby DPD, Hansen TO, Hansen ES, Knudsen GM, Bolwig TG, Rehfeld JF. Gene variations in the cholecystokinin system in patients with panic disorder. Psychiatr Genet 2010;20(2):59-64
  • Kornum BR, Stott SR, Mattsson B, Wismann L, Ettrup A, Hermening S, Knudsen GM, Kirik D. Adeno-associated viral vector serotypes 1 and 5 targeted to the neonatal rat and pig striatum induce widespread transgene expression in the forebrain. Exp Neurol 2010;222:70-85
  • Kramer V, Herth MM, Santini MA, Palner M, Knudsen GM, Rösch F. Structural combination of established 5-HT2A receptor ligands: New aspects of binding mode. Chem Biol Drug Des. 2010;76(4):361-6
  • Kupers R, Chebat DR, Madsen KH, Paulson OB, Ptito M. Neural correlates of virtual route recognition in congenital blindness. Proc Natl Acad Sci U S A 2010;107(28):12716-21
  • Licht CL, Kirkegaard L, Zueger M, Chourbaji S, Gass P, Aznar S, Knudsen GM. Changes in 5-HT4 receptor and 5-HT transporter binding in olfactory bulbectomized and glucocorticoid receptor heterozygous mice. Neurochem Int 2010;56(4):603-10
  • Licht CL, Knudsen GM, Sharp T. Effects of the 5-HT4 receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels. Neurosci Lett. 2010;476(2):58-61
  • Madsen KS, Baaré WF, Vestergaard M, Skimminge A, Ejersbo LR, Ramsøy TZ, Gerlach C, Akeson P, Paulson OB, Jernigan TL. Response inhibition is associated with white matter microstructure in children. Neuropsychologia 2010;48(4):854-62
  • Marner L, Gillings N, Madsen K, Erritzøe D, Baaré WF, Svarer C, Hasselbalch SG, Knudsen GM. Brain Imaging of Serotonin 4 Receptors in Humans with [11C]SB207145-PET. NeuroImage 2010;50(3):855-61
  • Mikkelsen JD, Thomsen MS, Hansen HH, Lichota J. Use of biomarkers in the discovery of novel anti-schizophrenia drugs. Drug Discov Today 2010;15(3-4):137-141
  • Miskowiak KW, Vinberg M, Harmer CJ, Ehrenreich H, Knudsen GM, Macoveanu J, Hansen AR, Paulson OB, Siebner HR, Kessing LV. Effects of erythropoietin on depressive symptoms and neurocognitive deficits in depression and bipolar disorder. Trials. 2010;13;11:97
  • Nielsen SB, Franzmann M, Basaiawmoit RV, Wimmer R, Mikkelsen JD, Otzen DE. beta-sheet aggregation of kisspeptin-10 is stimulated by heparin but inhibited by amphiphiles. Biopolymers. 2010;93(8):678-89
  • Palner M, McCormick P, Gillings N, Begtrup M, Wilson AA, Knudsen GM. Radiosynthesis and ex vivo evaluation of (R)-(-)-2-chloro-N-[1-11C-propyl]n-propylnorapomorphine. Nucl Med Biol 2010;37(1):35-40
  • Palner M, McCormick P, Parkes J, Knudsen GM, Wilson AA. Systemic catechol-O-methyl transferase inhibition enables the D1 agonist radiotracer R-[11C]SKF 82957. Nucl Med Biol 2010;37(7):837-43
  • Paterson LM, Tyacke RJ, Nutt DJ, Knudsen GM. Measuring endogenous 5-HT release by emission tomography: promises and pitfalls. J Cereb Blood Flow Metab. 2010;30(10):1682-706
  • Paulson OB, Hasselbalch SG, Rostrup E, Knudsen GM, Pelligrino D. Cerebral blood flow response to functional activation. J Cerebral Blood Flow Metab 2010;30(1):2-14
  • Paulson OB, Højgaard, L. Kortlægning af hjernens fysiologi og funktioner – de danske bidrag og den danske udvikling. Medicinsk Teknologi og Informatik 2010;7(4):30-32
  • Prabhakaran J, Majo JM, Milak MS, Kassir SA, Palner M, Savenkova L, Mali P, Arango V, Mann JJ, Parsey RV. Synthesis, in vitro and in vivo evaluation of [11C]MMTP: A potential PET ligand for mGluR1 receptors. Bioorg Med Chem Lett 2010;20(12):3499-501
  • Rasmussen H, Erritzøe D, Andersen R, Ebdrup BH, Aggernaes B, Oranje B, Kalbitzer J, Madsen J, Pinborg LH, Baaré W, Svarer C, Lublin H, Knudsen G, Glenthoj B. Decreased frontal serotonin2A receptor binding in antipsychotic-naïve patients with first-episode schizophrenia. Arch Gen Psychiatry 2010;67(1):9-16
  • Thomsen G, Knudsen GM. Procedure Guideline for Brain Perfusion SPECT Using 99mTc Radiopharmaceuticals 3.0. J Nucl Med Technol 2010;38(4):209
  • Thomsen MS, Hansen HH, Mikkelsen JD. Opposite effect of phenycyclidine on activity-regulated cytoskeleton-associated protein (arc) in juvenile and adult limbic rat brain regions. Neurochem Int 2010;56(2):270-5
  • Thomsen MS, Hansen HH, Timmerman DB, Mikkelsen JD. Cognitive improvement by activation of alpha7 nicotinic acetylcholine receptors: from animal models to human pathophysiology. Curr Pharm Des 2010;16(3):323-43
  • Thomsen MS, Hay-Schymidt A, Hansen HH, Mikkelsen JD. Distinct neural pathways mediate alpha7 nicotinic acetylcholine receptor-dependent activation of the forebrain. Cereb Cortex 2010;20(9):2092-102
  • Thomsen MS, Hansen HH, Mikkelsen JD. Alpha 7 nicotinic receptor agonism mitigates phencyclidine-induced changes in synaptophysin and Arc gene expression in the mouse prefrontal cortex. Neurochem Int. 2010;57(7):756-61.
  • Vinberg M, Frøkjær VG, Kessing LV. Coping styles in healthy individuals at risk of affective disorder. J Nerv Ment Dis 2010;198(1):39-44
  • Vrang N, Meyre D, Froguel P, Jelsing J, Tang-Christensen M, Vatin V, Mikkelsen JD, Thirstrup K, Larsen LK, Cullberg KB, Fahrenkrug J, Jacobson P, Sjöström L, Carlsson LM, Liu Y, Liu X, Deng HW, Larsen PJ. The imprinted gene neuronatin is regulated by metabolic status and associated with obesity. Obesity (Silver Spring) 2010;18(7):1289-96
  • Wellendorph P, Høg S, Sabbatini P, Pedersen MH, Martiny L, Knudsen GM, Frølund B, Clausen RP, Bräuner-Osborne H. N Novel radioiodinated GHB analogues for radiolabeling and photolinking of high-affinity GHB binding sites. J Pharmacol Exp Ther. 2010;335(2):458-64
  • Ziebell M, Korbo L, Hasselbalch SG. [Lewy body dementia]. Ugeskr Laeger. 2010;31;172(22):1675-8
  • Ziebell M, Pinborg LH, Thomsen G, de Nijs R, Svarer C, Wagner A, Knudsen GM. MRI-guided region-of-interest delineation is comparable to manual delineation in dopamine transporter SPECT quantification in patients: a reproducibility study. J Nucl Med Technol 2010;38(2):61-8
  • Ziebell M, Holm-Hansen S, Thomsen G, Wagner A, Jensen P, Pinborg LH, Knudsen GM. Serotonin transporters in dopamine transporter imaging: A head-to-head comparison of dopamine transporter SPECT radioligands [123I]FP-CIT and [123I]PE2I. J Nucl Med 2010;51(12):1885-91


Original publications in peer-reviewed journals (34)
  • Bendova Z, Sumova A, Mikkelsen JD. Circadian and developmental regulation of n-methyl-d-aspartate-receptor 1 mRNA splice variants and n-methyl-d-aspartate-receptor 3 subunit expression within the rat suprachiasmatic nucleus. Neuroscience 2009;159:599-609
  • Bundzikova J, Pirnik Z, Zelena D, Mikkelsen JD, Kiss A. Alpha2-adrenergic impact on hypothalamic magnocellular oxytocinergic neurons in long evans and brattleboro rats: effects of agonist and antagonists. Cell Mol Neurobiol 2009;29:1015-23
  • Butini S, Gemma S, Campiani G, Franceschini S, Trotta F,Borriello M, Ceres N, Ros S, Coccone SS, Bernetti M, Angelis MD, Brindisi M, Nacci V, Fiorini I, Novellino E, Cagnotto A, Mennini T, Sandager-Nielsen K, Andreasen JT, Scheel-Krüger J, Mikkelsen JD, Fattorusso C. Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: Design, synthesis, and effects on behavior. J Med Chem 2009;52:151-169
  • de Nijs R, Miranda MJ, Hansen LK, Hanson LG. Motion correction of single-voxel spectroscopy by independent component analysis applied to spectra from nonanesthetized pediatric subjects. Magn Reson Med 2009;62(5):1147-54
  • Erritzoe D, Frøkjær V, Haugbøl S, Marner L, Svarer C, Holst K, Baare W, Rasmussen PM, Madsen J, Paulson OB, Knudsen GM. Brain serotonin 2A receptor binding: Relations to body mass index, tobacco and alcohol use. Neuroimage 2009;46:23-30
  • Frøkjær V, Vinberg M, Erritzøe D, Svarer C, Baaré W, Budtz-Jørgensen E, Madsen K, Madsen J, Kessing LV, Knudsen GM. High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding. Neuroimage 2009;46:360-6
  • Frøkjær VG, Erritzøe D, Madsen J, Paulson OB, Knudsen GM. Gender and the use of hormonal contraception in women are not associated with cerebral cortical serotonin 2A receptor binding. Neuroscience 2009;163:640-5
  • Gerlach C. Category-specificity in visual object recognition. Cognition 2009;111:281-301
  • Herth MM, Kramer V, Piel M, Palner M, Riss PJ, Knudsen GM, Rösch F. Synthesis and in vitro affinities of various MDL 100907 derivates as potential (18)F-radioligands for 5-HT(2A) receptor imaging with PET. Bioorg Med Chem 2009;17:2989-3002
  • Jacobsen JP, Redrobe JP, Hansen HH, Petersen S, Bond CT, Adelman JP, Mikkelsen JD, Mirza NR. Selective cognitive deficits and reduced hippocampal brain-derived neurotrophic factor mRNA expression in small-conductance calcium-activated K+ channel deficient mice. Neuroscience 2009;163:73-81
  • Kalbitzer J, Frokjaer VG, Erritzoe D, Svarer C, Cumming P, Nielsen FÅ, Hashemi SH, Baaré WF, Madsen J, Hasselbalch SG, Kringelbach ML, Mortensen EL, Knudsen GM. The personality trait openness is related to cerebral 5-HTT levels. Neuroimage 2009;45:280-5
  • Kalbitzer J, Svarer C, Frokjaer VG, Erritzoe D, Baaré WF, Madsen J, Hasselbalch SG, Knudsen GM. A probabilistic approach to delineating functional brain regions. J Nucl Med Technology 2009;37:91-5
  • Knorr U, Vinberg M, Klose M, Feldt-Rasmussen U, Hilsted L, Gade A, Haastrup E, Paulson OB, Wetterslev J, Gluud C, Gether U, Kessing L. Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus placebo on the combined dexamethasone-corticotrophine releasing hormone test and other potential endophenotypes in healthy first-degree relatives of persons with depression. Trials 2009;10:66
  • Knudsen GM. Testing for radioligand sensitivity to endogenous neurotransmitter release. Eur J Nucl Med Mol Imaging 2009;36:472-4
  • Kornum BR, Lind NM, Gillings N, Marner L, Andersen F, Knuden GM. Evaluation of the novel 5-HT4 receptor PET ligand [11C]SB207145 in the Göttingen minipig. J Cereb Blood Flow Metab 2009;29:186-96
  • Kupers R, Frokjaer VG, Naert A, Christensen R, Budtz-Joergensen E, Kehlet H, Knudsen GM. A PET [18F]altanserin study of 5-HT2A receptor binding in the human brain and responses to painful heart stimulation. Neuroimage 2009;44:1001-7
  • Kupers R, Schneider FCG, Christensen R, Naert A, Husted H, Paulson OB, Kehlet H. No evidence for generalized increased postoperative responsiveness to pain: A combined behavioral and serial functional magnetic resonance imaging study. Anesth Analg 2009;109:600-6
  • Licht CL, Marcussen AB, Wegener G, Overstreet DH, Aznar S, Knudsen GM. The brain 5-HT4 receptor binding is downregulated in the Flinders Sensitive Line depression model and in response to paroxetine administration. J Neurochem 2009;109:1363-74
  • Marner L, Gillings N, Comley RA, Baaré WFC, Rabiner EA, Wilson AA, Houlse S, Hasselbalch SG, Svarer C, Gunn RN, Laruelle M, Knudsen GM. Kinetic modelling of [11C]SB207145 binding to 5-HT4 receptors in the human brain in vivo. J Nucl Med 2009;50:900-8
  • Marner L, Knudsen GM, Haugbøl S, Holm S, Baaré W, Hasselbalch SG. Longitudinal assessment of cerebral 5-HT2A receptors in healthy elderly volunteers: An [18F]-altanserin PET study. Eur J Nucl Med Mol Imaging 2009;36:287-93
  • Mikkelsen JD, Bentsen AH, Ansel L, Simonneaux V, Juul A. Comparison of the effects of peripherally administered kisspeptins. Regul Peptides 2009;152:95-100
  • Mikkelsen JD, Simonneaux V. The neuroanatomy of the kisspeptin system in the mammalian brain. Peptides 2009;30:26-33
  • Nielsen FA. Visualizing data mining results with the brede tools. Front Neuroinformatics 2009;3:26.1-12
  • Nielsen FA. Lost in localization: a solution with neuroinformatics 2.0?. Neuroimage 2009;48(1):11-3
  • Nielsen TR, Kornum BR, Moustgaard A, Gade A, Lind NM, Knudsen GM. A novel spatial delayed non-match to sample (DNMS) task in the Göttingen minipig. Behav Brain Res 2009;196:93-8
  • Ramsøy TZ, Liptrot MG, Skimminge A, Lund TE, Sidaros K, Christensen MS, Baaré W, Paulson OB, Jernigan TL. Regional activation of the human medial temporal lobe during intentional encoding of objects and positions. Neuroimage 2009;47:1863-72
  • Revel FG, Masson-Pévet M, Pévet P, Mikkelsen JD, Simonneaux V. Melatonin controls seasonal breeding by a network of hypothalamic targets. Neuroendocrinology 2009;90(1):1-14
  • Sidaros A, Skimminge A, Liptrot MG, Sidaros K, Engberg AaW, Herning M, Paulson OB, Jernigan TL, Rostrup E. Long-term global and regional brain volume changes following severe traumatic brain injury: A longitudinal study with clinical correlates. Neuroimage 2009;44:1-8
  • Simonneaux V, Ansel L, Revel FG, Klosen P, Pévet P, Mikkelsen JD. Kisspeptin and the seasonal control of reproduction in hamsters. Peptides 2009:30:146-53
  • Syvänen S, Lindhe Ö, Palner M, Kornum BR, Rahman O, Långström B, Knudsen GM, Hammarlund-Udenaes M. Species differences in blood-brain barrier transport of three PET radioligands with emphasis on P-glycoprotein transport. Drug Metab Dispos 2009;37:635-43
  • Thomsen MS, Christensen DZ, Hansen HH, Redrobe J, Mikkelsen JD. Alpha7 nicotinic acetylcholine receptor activation prevents behavioral and molecular changes induced by repeated phencyclidine treatment. Neuropharmacology 2009:56:1001-9
  • Trajkovska V, Kirkegaard L, Krey G, Marcussen AB, Thomsen MS, Chourbaji S, Brandwein C, Ridder S, Halldin C, Gass P, Knudsen GM, Aznar S. Activation of glucocorticoid receptors increases 5-HT2A receptor levels. Exp Neurol 2009;218:83-91
  • Trajkovska V, Santini MA, Marcussen AB, Thomsen MS, Hansen HH, Mikkelsen JD, Arneberg L, Kokaia M, Knudsen GM, Aznar S. BDNF downregulates 5-HT2A receptor protein levels in hippocampal cultures. Neurochem Int 2009;55:697-702
  • Vinberg M, Trajkovska V, Bennike B, Knorr U, Knudsen GM, Kessing LV. The BDNF Val66Met polymorphism: Relation to familiar risk of affective disorder, BDNF levels and salivary cortisol. Psychoneuroendocrinology 2009;34:1380-9
Books and book chapters
  • Gade A, Knudsen GM. Metaboliske, endokrine og andre systemiske sygdomme. In: Gade A, Gerlach C, Starrfelt R, Pedersen PM. Klinisk neuropsykologi. København: Frydenlund 2009:371-82
  • Marner L. Molekylær billeddannelse af hjernens serotoninsystem. BestPractice 2009:6-7
  • Paulson OB. Mogens Møller: Mogens Fog. Boganmeldelse. Ugeskr Laeger 2009
  • Jensen CG. Carsten Reidies Bjarkham: Neuroanatomi. Boganmeldelse. Indput 2009


Original publications in peer-reviewed journals (23)
  • Bundzikova J, Pirnik Z, Zelena D, Mikkelsen JD, Kiss A. Response of substances co-expressed in hypothalamic magnocellular neurons to osmotic challenges in normal and Brattleboro rats. Cell Mol Neurobiol 2008;28:1033-47
  • Christensen R, Marcussen AB, Wörtwein G, Knudsen GM, Aznar S. Aβ(1-42)injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT2A levels. Exp Neurol 2008;210:164-71
  • Dethloff TJ, Knudsen GM, Larsen FS. Cerebral blood flow autoregulation in experimental liver failure. J Cereb Blood Flow Metab 2008;28:916-26
  • Dyrby TB, Rostrup E, Baaré WFC, van Straaten ECW, Barkhof F, Vrenken H, Ropele S, Schmidt R, Erkinjuntti T, Wahlund L-O, Pantoni L, Inzitari D, Paulson OB, Hansen LK, Waldemar G. Segmentation of age-related white matter changes in a clinical multi-centre study. Neuroimage 2008;41:335-45
  • Erritzoe D, Rasmussen H, Kristiansen KT, Frokjaer VG, Haugbol S, Pinborg L, Baaré W, Svarer C, Madsen J, Lublin H. Knudsen GM, Glenthoj BY. Cortical and subcortical 5-HT2A receptor binding in neuroleptic-naive first-episode schizophrenic patients. Neuropsychopharmacol 2008;33:2435-41
  • Frokjaer VG, Mortensen EL, Nielsen FA, Haugbol S, Pinborg LH, Adams KH, Svarer C, Hasselbalch SG, Holm S, Paulson OB, Knudsen GM. Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder. Biol Psychiatry 2008;63:569-76
  • Frokjaer VG, Pinborg LH, Madsen J, de Nijs R, Svarer C, Wagner A, Knudsen GM. Evaluation of the serotonin transporter ligand 123I-ADAM for SPECT studies on Humans. J Nucl Med 2008;49:247-54
  • Hale MW, Hay-Schmidt A, Mikkelsen JD, Poulsen B, Shekhar A, Lowry CA. Exposure to an open-field arena increase c-Fos expression in a distributed anxiety-related system projecting to the basolateral amygdaloid complex. Neuroscience 2008;155:659-72
  • Hale MW, Hay-Schmidt A, Mikkelsen JD, Poulsen B, Bouwknecht JA, Evans AK, Stamper CE, Shekhar A, Lowry CA. Exposure to an open-field arena increase c-Fos expression in a subpopulation of neurons in the dorsal raphe nucleus, including neurons projecting to the basolateral amygdaloid complex. Neuroscience 2008;157:733-48
  • Hansen HH, Waroux O, Seutin V, Jentsch TJ, Aznar S, Mikkelsen JD. Kv7 channels: Interaction with dopaminergic and serotonergic neurotransmission in the CNS. J Physiol 2008;586:1823-32
  • Hasselbalch SG, Madsen K, Svarer C, Pinborg LH, Holm S, Paulson OB, Waldemar G, Knudsen GM. Reduced 5-HT2A receptor binding in patients with mild cognitive impairment. Neurobiol Aging 2008;29:1830-8
  • Herth MM, Debus F, Piel M, Palner M, Knudsen GM, Lüddens H, Rösch F. Total synthesis and evaluation of [18F]MHMZ. Bioorg Med Chem Let 2008;18:1515-19
  • Jacobsen JPR, Weikop P, Hansen HH, Mikkelsen JD, Redrobe JP, Holst D, Bond CT, Adelman JP, Christophersen P, Mirza NR. SK3 K+ channel-deficient mice have enhanced dopamine and serotonin release and altered emotional behaviors. Genes Brain Behav 2008;7:836-48
  • Kalowska E, Rostrup E, Rosenbaum S, Petersen P, Paulson OB. Acute MRI changes in progressive ischemic stroke. Eur Neurol 2008;59:229-36
  • Mikkelsen JD, Bundzikova J, Larsen MH, Hansen HH, Kiss A. GABA regulates the rat hypothalamic-pituitary-adrenocortical axis via different GABA-A receptor alpha-subtypes. Ann N Y Acad Sci 2008;1148:384-92
  • Pedersen M, Brandt C, Knudsen GM, Østergaard C, Skinhøj P, Skovsted IC, Frimodt-Møller N, Møller K. The effect of S. Pneumoniae bacteremia on cerebral blood flow autoregulation in rats. J Cereb Blood Flow Metab 2008;28:126-34
  • Pinborg LH, Arfan H, Haugbol S, Kyvik KO, Hjelmborg JvB, Svarer C, Frokjaer VG, Paulson OB, Holm S, Knudsen GM. The 5-HT2A receptor binding pattern in the human brain is strongly genetically determined. Neuroimage 2008;40:1175-80
  • Ptito M, Schneider FCG, Paulson OB, Kupers R. Alterations of the visual pathways in congenital blindness. Exp Brain Res 2008;187:41-9
  • Ryberg C, Rostrup E, Sjöstrand K, Paulson OB, Barkhoff F, Scheltens P, van Straaten EC, Fazekas F, Schmidt R, Erkinjuntti T, Wahlund LO, Basile AM, Pantoni L, Inzitari D, Waldemar G. White matter changes contribute to corpus callosum atrophy in the elderly: The LADIS Study.  Am J Neuroradiol 2008;29:1498-1504
  • Sidaros A, Engberg AaW, Sidaros K, Liptrot MG, Herning MG, Petersen P, Paulson OB, Jernigan TL, Rostrup E. Diffusion tensor imaging during recovery from severe traumatic brain injury and relation to clinical outcome: a longitudinal study. Brain 2008;131:559-72
  • Søderman A, Thomsen MS, Hansen HH, Nielsen EØ, Jensen MS, West MJ, Mikkelsen JD. The nicotinic α7 acetylcholine receptor agonist ssr 180711 is unable to activate limbic neurons in mice overexpressing human amyloid-β1-42. Brain Res 2008;1227:240-7
  • Thomsen G, de Nijs R, Hogh-Rasmussen E, Frokjaer V, Svarer C, Knudsen GM. Required time delay from 99mTc-HMPAO injection to SPECT data acquisition: healthy subjects and patients with rCBF pattern. Eur J Nucl Med Mol Imaging 2008;35:2212-19
  • Trajkovska V, Vinberg M, Aznar S, Knudsen GM, Kessing LV. Whole blood BDNF levels in healthy twins discordant for affective disorder: Association to life events and neuroticism. J Affect Disord 2008;108:165-9
Books and book chapters
  • Paulson OB, Knudsen GM. Comments on point: Counterpoint: Sympathetic activity does/does not influence cerebral blood flow. Role of a rudimentary sympathetic nervous system on cerebral blood flow. J Appl Physiol 2008;105:1371-2
  • Paulson OB. Heart and brain circulation in healthy men are differently affected by CO2. Acta Physiol 2008;193:203
  • Strandgaard S, Sigurdsson ST. Last word on point: Counterpoint: Sympathetic nervous activity does/does not influence cerebral blood flow. J Appl Physiol 2008:105:1366-7


Original publications in peer-reviewed journals (17)
  • Balslev D, Cole J, Miall RC. Proprioception contributes to the sense of agency during visual observation of hand movements: evidence from temporal judgments of action. J Cogn Neurosci 2007;19:1535-41
  • Christensen MS, Lundbye-Jensen J, Geertsen SS, Petersen TH, Paulson OB, Nielsen JB. Premotor cortex modulates somatosensory cortex during voluntary movements without proprioceptive feedback. Nat Neurosci 2007;10:417-9
  • Dyrby TB, Sogaard LV, Parker GJ, Alexander DC, Lind NM, Baare WF, Hay-Schmidt A, Eriksen N, Pakkenberg B, Paulson OB, Jelsing J. Validation of in vitro probabilistic tractography. Neuroimage 2007;37:1267-77
  • Elfving B, Madsen J, Knudsen GM. Neuroimaging of the serotonin reuptake site requires high affinity ligands. Synapse 2007;61:882-8
  • Gerlach C. A review of functional imaging studies on category specificity. J Cogn Neuroscience 2007;19:296-314
  • Hasselbalch SG, Hansen ES, Jacobsen TB, Pinborg LH, Lønborg JH, Bolwig TG. Reduced midbrain-pons serotonin transporter binding in patients with obsessive-compulsive disorder. Acta Psychiatr Scand 2007;115:388-94
  • Haugbol S, Pinborg LH, Regeur L, Hansen ES, Bolwig TG, Nielsen FA, Svarer C, Skovgaard LT, Knudsen GM. Cerebral 5-HT2A receptor binding is increased in patients with Tourette's syndrome. Int J Neuropsychopharmacol 2007 Apr;10(2):245-52
  • Haugbøl S, Pinborg LH, Arfan HM, Frøkjær V, Madsen J, Dyrby TB, Svarer C, Knudsen GM. Reproducibility of 5-HT2A receptor measurements and sample size estimations with [18F]altanserin PET using a bolus/infusion approach. Eur J Nucl Med Mol Imaging 2007;34:910-5
  • Kornum BR, Thygesen KS, Nielsen TR, Knudsen GM,  Lind NM. The effect of the inter-phase interval in the spontaneous object recognition test for pigs. Behav Brain Res 2007;181:210-7
  • Olling JD, Ulrichsen J, Haugbøl S, Glenthøj B, Hemmingsen R, Woldbye DP. Decreased gene expression of neuropeptide Y and its receptors in hippocampal regions during ethanol withdrawal in rats. Neurosci Lett 2007;424:160-4
  • Pedersen M, Brandt CT, Knudsen GM, Ostergaard C, Skinhoj P, Frimodt-Moller N, Moller K. Cerebral blood flow autoregulation in early experimental S. pneumoniae meningitis. J Appl Physiol 2007;102(1):72-8
  • Pinborg LH, Videbaek C, Ziebell M, Mackeprang T, Friberg L, Rasmussen H, Knudsen GM, Glenthoj BY. [123I]Epidepride binding to cerebellar dopamine D2/D3 receptors is displaceable: Implications for the use of cerebellum as a reference region. Neuroimage 2007;34:1450-3
  • Rowe JB, Sakai K, Lund TE, Ramsøy T, Christensen MS, Baare WFC, Paulson OB, Passingham RE. Is the prefrontal cortex necessary for establishing cognitive sets? J Neuroscience 2007;27:13303-10
  • Severino M, Pedersen AF, Trajkovska V, Christensen E, Lohals R, Veng LM, Knudsen GM, Aznar S. Selective immunolesion of cholinergic neurons leads to long-term changes in 5-HT2A receptor levels in hippocampus and frontal cortex. Neurosci Lett 2007;428:47-51
  • Starrfelt R, Gerlach C. The visual what for area: Words and pictures in the left fusiform gyrus. Neuroimage 2007;35:334-42
  • Trajkovska V, Marcussen AB, Vinberg M, Hartvig P, Aznar S, Knudsen GM. Measurements of brain-derived neurotrophic factor: Methodological aspects and demographical data. Brain Res Bull 2007;73:143-9
  • Ziebell M, Thomsen G, Knudsen GM, de Nijs R, Svarer C, Wagner A, Pinborg LH.  Reproducibility of [(123)I]PE2I binding to dopamine transporters with SPECT. Eur J Nucl Med Mol Imaging 2007;34:101-9
Books and book chapters
  • Innis RB, Cunningham VJ, Delforge J, Fujita M,  Gjedde A, Gunn RN, Holden J, Houle S, Huang S-C, Ichise M, Iida H, Ito H, Kimura Y, Koeppe RA, Knudsen GM, Knuuti J, Lammertsma AA, Laruelle M, Logan J, Maguire RP, Mintun MA, Morris ED, Parsey R, Price JC, Slifstein M, Sossi V, Suhara T, Votaw JR, Wong DF, Carson RE. Consensus nomenclature for in vivo imaging of reversibly-binding radioligands.  J Cereb Blood Flow Metab, 2007:27;1533-9
  • Knudsen GM. Emotioner og hjernens transmittersystemer. In: Jensen TW, Skov M, eds. Følelser og kognition. København: Museum Tusculanums Forlag, 2007:113-25
  • Paulson OB, Balslev D, Gerlach C. Hvad er PET og fMRI? In: Jensen TW, Skov M, eds. Følelser og kognition. København: Museum Tusculanums Forlag, 2007:37-53
  • Paulson OB, Parving HH. Niels A. Lassens banebrydende forskning. Ugeskr Laeger 2007;169:2899
  • Ramsøy T, Balslev D, Paulson OB. Methods for observing the living brain. In: Baars BJ, Gage NM, eds. Cognition, brain and consciousness. Amsterdam: Academic Press, 2007:477-511
  • Sigurdsson ST, Strandgaard S. Blood pressure lowering in acute ischaemic stroke: an update on the role of angiotensin receptor blockers. J Hypertens 2007;25:743-5
  • Skov M, Stjernfelt F, Paulson OB. Language and the brain’s mental cinema. In: Grundtvig B, McLaughlin M, Petersen LW, eds. Image, eye and art in Calvino. London: Modern Humanities Research Association and Maney Publishing, 2007:185-99
  • Strandgaard S, Paulson OB. Hypertension and brain. In: Anand MP, Nadkar MY, eds. Hypertension. India: IJCP Group of Publications, 2007;137-42. Strandgaard S, Paulson OB. Management of hypertension with cerebrovascular disease. In: Anand MP, Nadkar MY, eds. Hypertension. India: IJCP Group of Publications, 2007;268-7


Original publications in peer-reviewed journals (15)
  • Andersen PB, Blinkenberg M, Lassen U, Kosteljanetz M, Wagner A, Poulsen HS, Sørensen PS, Paulson OB. A prospective PET study of patients with glioblastoma multiforme. Acta Neurol Scand 2006;116:412-8
  • Balslev D, Nielsen FAa, Lund TE, Law I, Paulson OB. Similar brain networks for detecting visuo-motor and visuo-proprioceptive synchrony. Neuroimage 2006;31:308-12
  • Frøkjær VG, Strauss GI, Mehlsen J, Knudsen GM, Rasmussen V, Larsen FS. Autonomic dysfunction and impaired cerebral autoregulation in cirrhosis. Clin Auton Res 2006;16:208-16
  • Gerlach C, Law I, Paulson OB. Shape configuration and category-specificity. Neuropsychologia 2006;44:1247-60
  • Glenthoj BY, Mackeprang T, Svarer C, Rasmussen H, Pinborg LH, Friberg L, Baaré W, Hemmingsen R, Videbaek C. Frontal dopamine D2/3 receptor binding in drug-naive first-episode schizophrenic patients correlates with positive psychotic symptoms and gender. Biol Psychiatry 2006;60:621-9
  • Husum H, Aznar S, Høyer-Hansen S, Larsen MH, Mikkelsen JD, Møller A, Mathé AA, Wörtwein G. Exacerbated loss of cell survival, neuropeptide Y-immunoreactive (IR) cells, and serotonin-IR fiber lengths in the dorsal hippocampus of the aged flinders sensitive line “depressed” rat: Implications for the pathophysiology of depression? J Neuroscience Res 2006;84:1292-1302
  • Kondziella D, Brenner E, Eyjolfsson EM, Markinhuhta KR, Carlsson ML, Sonnewald U. Glial-neuronal interactions are impaired in the schizophrenia model of repeated MK801 exposure. Neuropsychopharmacology 2006;31(9):1880-7
  • Kornum BR, Weikop P, Møller A, Ronn LCB, Knudsen GM, Aznar S. Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus. Brain Research 2006;1073-1074:262-8
  • Kornum BR, Licht CL, Weikop P, Knudsen GM, Aznar S. Central serotonin depletion affects rat brain areas differently: A qualitative and quantitative comparison between different treatment schemes. Neurosci Lett 2006;392:129-34
  • Lindberg C, Koefoed P, Hansen ES, Bolwig TG, Rehfeld JF, Mellerup E, Jorgensen OS, Kessing LV, Werge T, Haugbol S, Wang AG, Woldbye DP. No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population. Acta Psychiatr Scand 2006;113:54-8
  • Linde R, Hasselbalch SG, Topp S, Paulson OB, Madsen PL. Global cerebral blood flow and metabolism during acute hyperketonemia in the awake and anesthetized rat. J Cereb Blood Flow Metab 2006;26:170-80
  • Mathiesen HK, Jonsson A, Tscherning T, Hanson LG, Andresen J, Blinkenberg M, Paulson OB, Sorensen PS. Correlation of global N-acetyl aspartate with cognitive impairment in multiple sclerosis. Arch Neurol 2006;63:533-6
  • Nielsen K, Rostrup E, Frederiksen JL, Knudsen S, Mathiesen HK, Hanson LG, Paulson OB. Magnetic resonance imaging at 3.0 Tesla detects more lesions in acute optic neuritis than at 1.5 Tesla. Invest Radiol 2006;41:76-82
  • Nielsen K, Brask D, Knudsen GM, Aznar S. Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse 2006;59:270-6
  • Scheuer KH, Nielsen JE, Krabbe K, Paulson OB, Law I. Motor activation in SPG4 linked hereditary spastic paraplegia. J Neurol Sci 2006;244:31-9
Books and book chapters
  • Hasselbalch SG, Knudsen GM. Imaging of neurotransmitter systems in dementia. In: Herholz K, Perani D, Morris C, eds. The Dementias. Early Diagnosis and Evaluation. New York: Taylor and Francis Group 2006:253-77


Original publications in peer-reviewed journals (21)
  • Adams KH, Hansen ES, Pinborg LH, Hasselbalch SG, Svarer C, Holm S, Bolwig TG, Knudsen GM. Patients with obsessive-compulsive disorder have increased 5-HT2A receptor binding in the caudate nuclei. Int J Neuropsychopharmacol 2005;8:391-401
  • Aznar S, Kostova V, Christiansen SH, Knudsen GM. Alpha7 nicotinic receptor subunit is present on serotonin neurons projecting to hippocampus and septum. Synapse 2005;55(3):196-200
  • Balslev D, Nielsen FÅ, Paulson OB, Law I. Right temporoparietal cortex activation during visuo-proprioceptive conflict. Cereb Cortex 2005;15:166-9
  • Dethloff T, Knudsen GM, Hansen BA, Larsen FS. Effects of porta-systemic shunting and ammonia infusion on cerebral blood flow autoregulation in the rat. Neurocrit Care 2005;3(1):86-90
  • Fenger MM, Gade A, Adams KH, Hansen ES, Bolwig TG, Knudsen GM. Cognitive deficits in obsessive-compulsive disorder on tests of frontal lobe functions. Nord J Psychiatry 2005;59:39-44
  • Garde E, Lykke Mortensen E, Rostrup E, Paulson OB. Decline in intelligence is associated with progression in white matter hyperintensity volume. J Neurol Neurosurg Psychiatry 2005;76:1289-91
  • Gerlach C, Marstrand L, Habekost T, Gade A. A case of impaired shape integration: Implications for models of visual object processing. Visual Cognition 2005;12(8):1409-43
  • Jelsing J, Rostrup E, Markenroth K, Paulson OB, Gundersen HJG, Hemmingsen R, Pakkenberg B. Assessment of in vivo MR imaging compared to physical sections in vitro - A quantitative study of brain volumes using stereology. NeuroImage 2005;26:57-65
  • Kristiansen H, Elfving B, Plenge P, Pinborg LH, Gillings N, Knudsen GM. Binding characteristics of the 5-HT2A receptor antagonists altanserin and MDL100907. Synapse 2005 Dec 15;58(4):249-57
  • Mathiesen HK, Tscherning T, Sørensen PS, Larsson HBW, Rostrup E, Paulson OB, Hanson LG. Multi-slice echo-planar spectroscopic MR imaging provides both global and local metabolite measures in multiple sclerosis. Magn Reson Med 2005;53:750-9
  • Nielsen FÅ, Balslev D, Hansen LK. Mining the posterior cingulate: Segregation between memory and pain components. Neuroimage 2005;27:520-32
  • Pinborg LH, Ziebell M, Frøkjær VG, de Nijs R, Svarer C, Haugbøl S, Yndgaard S, Knudsen GM. Quantification of 123I-PE2I binding to dopamine transporter with SPECT after bolus and bolus/infusion. J Nucl Med 2005;46:1119-27
  • Pryds A, Tønnesen J, Knudsen GM, Greisen G. Cerebral autoregulation in a rat pup model. Pediatr Res. 2005;57:294-8
  • Rostrup E, Knudsen GM, Law I, Holm S, Larsson HB, Paulson OB. The relationship between cerebral blood flow and volume in humans. Neuroimage 2005;24:1-11
  • Rostrup E, Larsson HBW, Born AP, Knudsen GM, Paulson OB. Changes in BOLD and ADC weighted imaging in acute hypoxia during sea-level and altitude adapted states. Neuroimage 2005;28:947-55
  • Scheuer KH, Nielsen JE, Krabbe K, Simonsen C, Koefoed P, Sorensen SA, Gade A, Paulson OB, Law I. Reduced regional cerebral blood flow in SPG4-linked hereditary spastic paraplegia. J Neurol Sci 2005;15;235:23-32
  • Svarer C, Madsen K, Hasselbalch SG, Pinborg LH, Haugbøl S, Frøkjær VG, Holm S, Paulson OB, Knudsen GM. MR-based automatic delineation of volumes of interest in human brain PET-images using  probability maps. NeuroImage 2005;24:969-79
  • Søndergaard K, Kristensen JL, Palner M, Gillings N, Knudsen GM, Roth BL, Begtrup M. Synthesis and binding studies of 2-arylapomorphines. Org Biomol Chem 2005;3(22):4077-81
  • Tønnesen J, Pryds A, Larsen EH, Paulson OB, Hauerberg J, Knudsen GM. Laser Doppler flowmetry is valid for measurement of cerebral blood flow autoregulation lower limit in rats. J Exp Physiol 2005;90:349-55
  • Søndergaard K, Kristensen JL, Gillings N, Begtrup M. Synthesis of (R)-(-)-2-fluoronorapomorphine - A precursor for the synthesis of (R)-(-)-2-fluoro-N[11C}propylnorapomorphine for evaluation as a dopamine D2 agonist ligand for PET investigations. Eur J Org Chem 2005;20:4428-33
  • Vogel A, Hasselbalch SG, Gade A, Ziebell M, Waldemar G. Cognitive and functional neuroimaging correlates for anosognosia in Mild Cognitive Impairment and Alzheimer’s disease. Int J Geriatr Psychiatry 2005;20:238-46
Books and book chapters
  • Knudsen GM, Paulson OB, Petersen P. Neurologiske sygdomme. I: Hansen NE, Haunsø S, de Muckadell OBS, eds. Medicinsk Kompendiums Lommebog, 3. udgave. København: Nyt Nordisk Forlag Arnold Busck A/S, 2005:526-68


Original publications in peer-reviewed journals (17)
  • Adams KH, Pinborg LH, Svarer C, Hasselbalch SG, Holm S, Mortensen EL, Haugbøl S, Madsen K, Frokjaer V, Martiny L, Paulson OB, Knudsen GM: A database of [18F]-altanserin binding to 5-HT2A receptors in normal volunteers: normative data and relationship to physiological, and demographic variables. NeuroImage 2004;21:1105-13
  • Aznar S, Qian ZX, Knudsen GM. Non-serotonergic dorsal and median raphe projection on parvalbumin- and calbindin-containing neurons in hippocampus and septum. Neuroscience 2004;124(3):573-81
  • Balslev D, Christensen LOD, Lee J-H, Law I,  Paulson OB, Miall RC. Enhanced accuracy in novel mirror drawing after repetitive transcranial magnetic stimulation-induced proprioceptive deafferentation. J Neurosci 2004;24:9698-9702
  • Cohen ER, Rostrup E Sidaros K Lund TE, PaulsonOB, Ugurbil K, Kim S-G. Hypercapnic normalization of BOLD fMRI: comparison across field strengths and pulse sequences. Neuroimage 2004;23:613-24
  • Fumagalli M, Mosca F, Knudsen GM, Greisen G. Transient hyperoxia and residual cerebrovascular effects in the newborn rat. Pediatr Res 2004;55(3):380-4
  • Fumagalli M, Mosca F, Knudsen GM, Greisen G.  A newborn rat model for the study of cerebral hemodynamics by near-infrared spectroscopy and laser-Doppler flowmetry in the immature brain. Biol Neonate 2004;85(2):112-20
  • Gerlach C, Law I, Paulson OB. Structural similarity and category-specificity: a refined account. Neuropsychol 2004;42:1543-53
  • Humphreys GW, Kylingsbæk S, Watson DG, Olivers CNL, Law I, Paulson OB. Parieto-occipital areas involved in efficient filtering in search: A time course analysis of visual marking using behavioural and functional imaging procedures. Q J Exp Psychol A 2004;57:610-35
  • Knudsen GM, Karlsborg M, Thomsen G, Krabbe K, Regeur L, Nygaard T, Videbæk C, Werdeling L. Imaging of dopamine transporters and D2 receptors in patients with Parkinsons disease and multiple system atrophy. Eur J Nuclear Med Mol Imaging 2004;12:1631-8
  • Liptrot M, Adams KH, Martiny L, Pinborg LH, Lonsdale MN, Olsen NV, Holm S, Svarer C, Knudsen GM: Cluster analysis in kinetic modelling of the brain: a non-invasive alternative to arterial sampling. NeuroImage 2004;21:483-493
  • Madsen J, Elfving B, Andersen K, Martiny L, Knudsen GM. Gas phase production of [11C]methyl iodide-d3. Synthesis and biological evaluation of S-[N-methyl-11C]citalopram and deuterated analogues. J Label Compd Radiopharm 2004;47:335-48
  • Møller K, Qvist T, Tofteng F, Sahl C, Sønderkær S, Dethloff T, Knudsen GM, Larsen FS. Cerebral blood flow and metabolism during infusion of norepinephrine and propofol in patients with bacterial meningitis. Stroke 2004;35:1333-9
  • Nielsen FA, Hansen LK, Balslev D. Mining for associations between text and brain activation in a functional neuroimaging database. Neuroinformatics 2004;4:369-80
  • Nielsen JE, Johnsen B, Koefoed P, Scheuer KH, Grønbech-Jensen M, Law I, Krabbe K, Nørremølle A, Eiberg H, Søndergård H, Dam M, Rehfeld JF, Krarup C, Paulson OB, Hasholt L, Sørensen SA. Hereditary spastic paraplegia with cerebellar ataxia: a complex phenotype associated with a new SPG4 gene mutation. Eur J Neurol 2004;11:817-24
  • Pinborg LH, Adams KH, Yndgaard S, Hasselbalch SG, Holm S, Kristiansen H, Paulson OB. Knudsen GM. [18F]altanserin binding to human 5HT2A receptors is unaltered after citalopram and pindolol challenge. J Cereb Blood Flow Metab 2004;24:1037-45
  • Quarantelli M, Berkouk K, Prinster A, Landeau B, Svarer C, Balkay L, Alfano B, Brunetti A, Baron JC, Salvatore M. Integrated Software for the Analysis of Brain PET/SPECT Studies with Partial-Volume-Effect Correction. J Nucl Med 2004;45:192-201
  • Sveen ML, Knudsen GM, Aznar S. No effect of MDMA (ecstasy) on cell death and 5-HT(2A) receptor density in organotypic rat hippocampal cultures. Neurosci Lett. 2004;362:6-9
Books and book chapters
  • Eskesen V, Paulson OB. Bevidsthedssvækkelse og bevidstløshed. I: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 4. udg. København: FADL, 2004:197-214
  • Knudsen GM, Paulson OB. Hjernens fysiologi. I: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 4. udg. København: FADL, 2004:239-54
  • Knudsen GM, Sørensen PSS. Neurologiske manifestationer ved systemiske sygdomme. I: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. København: FADL’s Forlag. 4. udg. 2004:609-28
  • Knudsen GM, Rostrup E, Hasselbalch SG. Quantitative PET for assessment of cerebral blood flow and glucose consumption under varying physiological conditions. Int Congress Series 2004;1265:189-200
  • Paulson OB. Mobiltelefoni - kan det påvirke blod-hjerne-barrieren? Ugeskr Læger 2004;13:1209-11
  • Paulson OB, Boysen G, Krarup C, Knudsen GM, Sørensen PS. Neurologi. I: Hansen NE, Haunsø S, Schaffalitzky de Muckadell OB, eds. Medicinsk Kompendium, 16. udgave. København: Nyt Nordisk Forlag, 2004:2505-2703
  • Paulson OB, Gjerris F. Introduktion til klinisk neurologisk undersøgelse. I: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 4. udg. København: FADL, 2004:21-26
  • Paulson OB, Gjerris F. Det motoriske system. I: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 4. udg. København: FADL, 2004:69-112
  • Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 4. udg. København: FADL, 2004:1-648
  • Sørensen PSS, Paulson OB. Det sensoriske system. I: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 4. udg. København: FADL, 2004:55-68
  • Sørensen PS, Paulson OB. Intoksikationer og ernæringsdeficit. I: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 4. udg. København: FADL, 2004:537-58
  • Vorstrup S, Paulson OB. Defekter i den neuromuskulære transmission. I: Paulson OB, Gjerris F, Sørensen PS (eds). Klinisk neurologi og neurokirurgi. 4. udg. København: FADL, 2004:585-92
  • Willendrup P, Pinborg LH, Hasselbalch SG, Adams KH, Stahr K, Knudsen GM, Svarer C: Assessment of the precision in co-registration of structural MR-images and PET-images with localized binding. Int Congress Series 2004;1265:275-80


Original publications in peer-reviewed journals (8)
  • Andersen PB, Krabbe K, Leffers AM, Schmiegelow M, Holm S, Laursen H, Müller JR, Paulson OB. Cerebral glucose metabolism in long-term survivors of childhood primary brain tumors treated with surgery and radiotherapy. J Neurooncol 2003;63:305-13
  • Aznar S, Qian Z, Shah R, Rahbek B, Knudsen GM: The 5-HT1A serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain. Brain Res 2003;959:58-67
  • Bay-Hansen R, Ma XD, Hauerberg J, Larsen EH, Juhler M. Effects of cerebrospinal fluid acidity on cerebral blood flow and autoregulation in rats. J Neurosurg Anesth 2003;15:110-8
  • Elfving B, Bjørnholm B, Knudsen GM: Interference of anaesthetics with radioligand binding in neuroreceptor studies. Eur J Nucl Med 2003;30:912-5
  • Madsen J, Marachtsaki P, Davoodpour P, Bergström M, Långström B, Andersen K, Thomsen C, Martiny L, Knudsen GM. Synthesis and biological evaluation of novel carbon-11-labelled analogues of citalopram as potential radioligands for the serotonin transporter. Bioorg Med Chem 2003;11:3447-56
  • Pedersen TF, Paulson OB, Nielsen AH, Strandgaard S. Effect of nephrectomy and captopril on autoregulation of cerebral blood flow in rats. Am J Physiol Heart Circ Physiol 2003;285:1097-104
  • Pinborg LH, Adams KH, Svarer C, Holm S, Hasselbalch SG, Haugbøl S, Madsen J, Knudsen GM. Quantification of 5-HT2A receptors in the human brain using [18F]Altanserin-PET and the bolus/infusion approach. J Cereb Blood Flow Metab 2003;23:985-96
  • Strauss GI, Møller K, Larsen FS, Kondrup J, Knudsen GM: Cerebral glucose and oxygen metabolism in patients with fulminant hepatic failure. Liver Transpl. 2003;9:1244-52
Books and book chapters
  • Højgaard L, Eigtved A, Paulson OB. Brain metastases, intracranial lymphomas, and nongliomatous tumors. In: Von Schulthess GK, ed. Clinical molecular anatomic imaging. Philadelphia: Lippincott Williams & Wilkins, 2003:169-74
  • Hasselbalch SG. Neuroreceptor imaging with positron emission tomography in dementia. Dementia 2003;4:2-7


Original publications in peer-reviewed journals (22)
  • Abildstrom H, Hogh P, Sperling B, Moller JT, Yndgaard S, Rasmussen LS. Cerebral blood flow and cognitive dysfunction after coronary surgery. Ann Thorac Surg 2002;73:1174-8
  • Balslev D, Nielsen FAA, Frutiger SA, Sidtis JJ, Christiansen TB, Svarer C, Strother SC, Rottenberg DA, Hansen LK, Paulson OB, Law I. Cluster analysis of activity-time series in motor learning. Human Brain Mapping 2002;15:135-45
  • Bay-Hansen R, Elfving B, Greisen G. Use of near infrared spectroscopy for estimation of peripheral venous saturation in newborns: comparison with co-oximetry of central venous blood. Biol Neonate 2002;82:1-8
  • Born A P, Law I, Lund T E, Rostrup E, Hanson L G P, Wildschiødtz G, Lou H C, Paulson O B. Cortical deactivation induced by visual stimulation in Human Slow-Wave Sleep. Neuroimage 2002;17:1325-35
  • Bundesen C, Larsen A., Kyllingsbæk, S, Paulson O B, Law I. Attentional effects in early visual pathways: A whole-brain PET study. Exp Brain Res 2002;147:394-406
  • Elfving B, Bjørnholm B, Knudsen GM. Predosing with the unlabeled inactive enantiomer as a tool for improvement of the PET signal. Synapse 2002;46:125-127
  • Gerlach C, Law I, Gade A, Paulson OB. The role of action knowledge in the comprehension of artefacts - A PET study. NeuroImage 2002;15:143-52
  • Gerlach C, Aaside CT, Humphreys GW, Gade A, Paulson OB, Law I. Brain activity related to integrative processes in visual object recognition: bottom-up integration and the modulatory influence of stored knowledge. Neuropsychologia 2002;40:1254-67
  • Gerlach C, Law I, Paulson OB. When action turns into words. Activation of motor-based knowledge during categorization of manipulable objects. J Cogn Neuroscience 2002;14:1230-9
  • Hansen ES, Hasselbalch S, Law I, Bolwig TG. The caudate nucleus in obsessive-compulsive disorder. Reduced metabolism following treatment with paroxetine: a PET study. Int J Neuropsychopharm 2002;5:1-10
  • Hesse B, Mehlsen J, Boesen F, Schmidt JF, Andersen EB, Waldemar G, Andersen AR, Paulson OB, Vorstrup S. Regulation of cerebral blood flow in patients with autonomic dysfunction and severe postural hypotension. Clin Physiol & Func Im 2002;22:241-7
  • Kjær T, Law I, Wildschiødtz G, Paulson, O B, Madsen P L. Regional cerebral blood flow during light sleep - A H215O-PET study. J Sleep Res 2002;11:201-7
  • Møller K, Paulson OB, Hornbein TF, Colier W, Roach R, Knudsen GM. Unchanged cerebral blood flow and oxidative metabolism after acclimatization to high altitude. J Cereb Blood Flow Metabol 2002; 22:118-26
  • Møller K, Strauss GI, Thomsen G, Larsen FS, Holm S, Sperling BK, Skinhøj P, Knudsen GM. Cerebral blood flow, oxidative metabolism, and cerebrovascular carbon dioxide reactivity in patients with acute bacterial meningitis. Acta Anaesthesiol Scand 2002;46:567-78
  • Møller K, Strauss GI, Qvist J, Fonsmark L, Knudsen GM, Larsen FS, Krabbe KS, Skinhøj P, Pedersen BK. Cerebral blood flow and oxidative metabolism during human endotoxemia. J Cereb Blood Flow Metab 2002;22:1262-70
  • Pedersen TF, Nielsen AH, Strandgaard S, Paulson OB. Nephrectomy and peritoneal dialysis eliminates circulating renin and controls uraemia in the rat. JRAAS 2002;3:130-4
  • Pinborg LH, Videbæk C, Svarer C, Yndgaard S, Paulson OB, Knudsen GM. Quantification of [123I]PE2I binding to dopamine transporters with SPET.  Eur J Nucl Med 2002;29:623-31
  • Rabiner EA, Messa C, Sargent PA, Husted-Kjaer K, Montgomery A, Lawrence AD, Bench CJ, Gunn RN, Cowen P, Grasby PM. A database of [11C]WAY-100635 binding to 5-HT1A receptors in normal male volunteers: Normative data and relationship to methodological, demographic, physiological, and behavioral variables. Neuroimage 2002;15:620-32
  • Rasmussen LS, Sperling B, Abildstrom HH, Moller JT. Neuron loss after coronary artery bypass detected by SPECT estimation of benzodiazepine receptors.Ann Thorac Surg 2002;74:1576-80
  • Rostrup E, Law I, Pott F, Ide K, Knudsen G M. Cerebral hemodynamics measured with simultaneous PET and near-infrared spectroscopy in humans. Brain Res 2002;954:183-93
  • Schmalbruch IK, Linde R, Paulson OB, Madsen PL. Activation-induced resetting of cerebral metabolism and flow is abolished by ?-adrenergic blockade with propranolol. Stroke 2002;33:251-5
  • Springborg JB, Ma X, Rochat P, Knudsen GM, Amtorp A, Paulson OB,  Juhler M, Olsen NV. A single subcutaneous bolus of erythropoietin normalizes cerebral blood flow autoregulation after subarachnoid hemorrhage in rats. Br J Pharmacol 2002;135:823-9
Books and book chapters
  • Knudsen GM. Funktionel billeddannelse af receptorforandringer ved parkinsonisme: Emissionstomografiske metoder til hjælp i diagnostikken. Ugeskr Laeger 2002;22:2259-62
  • Knudsen GM, Svarer C. Neuroreceptor imaging: Considerations for design, data analysis, and interpretation. In: Senda M, Kimura Y, Herscovitch P (eds). Brain imaging using PET. San Diego: Academic Press, 2002:p.23-6
  • Law I, Roach RC, Olsen NV, Holm S, Nowak M, Hornbein TF, Paulson  OB. Oxygen delivery to the brain during behavioral activation at acute normobaric hypoxemia. In: Tomita M, Kanno I, and Hamel E, eds. Brain activation and CBF control. Excerpta Medica. International Congress Series nr 1235, Elsevier Science. 2002, 87 – 98
  • Paulson OB, Law I. Hemodynamic and metabolic features of cerebral activation. In: Tomita M, Kanno I, and Hamel E, eds. Brain activation and CBF control. Amsterdam: Elsevier, 2002;205-12
  • Paulson OB, Born AP, Bundesen C, Gade A, Gerlach C, Hansen LK, Holm S, Jensen M, Kyllingsbæk S, Larsen A, Law I, Rostrup E, Svarer C. Den arbejdende hjerne - hvordan kan den se ud? Ugeskr Læg 2002;164:2267-75
  • Paulson OB. Blood-brain barrier, brain metabolism and cerebral blood flow. Eur Neuropsychopharmacol 2002;12:495-501
  • Willendrup P, Svarer C, Hanson LG, Paulson OB. A simple approach to combined inhomogeneity correction and tissue segmentation of MR MPRAGE images. In: Senda M, Kimura Y, Herscovitch P (eds). Brain imaging using PET. San Diego: Academic Press, 2002:p.159-62


Original publications in peer-reviewed journals (19)
  • Aznar S, Knudsen GM: Serotonin induces decrease of 5-HT1A immunoreactivity in organotypic hippocampal cultures. NeuroReport 2001;12:3909-12
  • Bech-Azeddine R, Waldemar G, Knudsen GM, Høgh P, Bruhn P, Wildschiødtz G, Gjerris F, Paulson OB, Juhler M. Idiopatic normal-pressure hydrocephalus: evaluation and findings in a multidisciplinary memory clinic. Eur J Neurol 2001;8:601-11
  • Blinkenberg M, Rune K, Jensen CV, Ravnborg MH, Kyllingsbæk S, Holm S, Paulson OB, Sørensen PS. Reduceret cerebralt stofskifte korrelerer med MRI-forandringer og kognitiv dysfunktion hos patienter med dissemineret sklerose. Ugeskr Læg 2001;163:3788-92
  • Elfving B, Bjørnholm B, Ebert B, Knudsen GM: Binding characteristics of selective serotonin reuptake inhibitors with relation to emission tomography studies. Synapse 2001;41:203-11
  • Estrup TM, Paulson OB, Strandgaard. No effect of angiotensin II AT2 receptor antagonist PD123319 on cerebral blood flow autoregulation. JRAAS 2001;2:188-92
  • Gerlach C. Structural similarity causes different category-effects depending on task characteristics. Neuropsychologia 2001;39:895-900
  • Gruhn N, Larsen FS, Boesgaard S, Knudsen GM, Mortensen SA, Thomsen G, Aldershvile J. Cerebral blood flow in patients with chronic heart failure before and after heart transplantation. Stroke 2001;32: 2530-3
  • Hasselbalch SG, Holm S, Pedersen HS, Svarer C, Knudsen GM, Madsen PL, Paulson OB. The 18F-fluorodeoxyglucose lumped constant determined in human brain from extraction fractions of 18F-fluorodeoxyglucose and glucose. J Cereb Blood Flow Metab 2001;21:995-1002
  • Hasselbalch SG, Knudsen GM, Capaldo B, Postiglione A, Paulson OB. Blood-brain barrier transport and brain metabolism of glucose during acute hyperglycemia in humans. J Clin Endocrinol Metab 2001;86; 1986-90
  • Høgh P, Knudsen GM, Kjaer KH, Jørgensen OS, Paulson OB, Waldemar G. SPECT and apolipoprotein E in Alzheimer’s disease: Impact of the epsilon-4 allele on regional cerebral blood flow. J Geriatr Psychiatry Neurol 2001;14:42-51
  • Law I, Jensen M, Holm S, Nickles RJ, Paulson OB. Using 10CO2 for single subject characterization of the stimulus frequency dependence in visual cortex: A novel positron emission tomography tracer for human brain mapping. J Cereb Blood Flow Metab 2001;21:1003-12
  • Pinborg LH, Videbæk C, Hasselbalch SG, Sørensen SA, Wagner A, Paulson OB, Knudsen GM. Benzodiazepine receptor quantification in Huntington’s disease with [123I]iomazenil and SPECT. J Neurol Neurosurg Psychiatry 2001;70:657-61
  • Schreiber K, Sorensen PS, Koch-Henriksen N, Wagner A, Blinkenberg M, Svarer C, Petersen HC. Correlations of brain MRI parameters to disability in multiple sclerosis. Acta Neurol Scand 2001;104:24-30
  • Strauss GI, Møller K, Holm S, Sperling B, Knudsen GM, Larsen FS. Transcranial doppler sonography and internal jugular bulb saturation during hyperventilation in patients with fulminant hepatic failure. Liver Transpl 2001;7:352-8
  • Strauss GI, Knudsen GM, Kondrup , Møller K, Larsen FS. Cerebral metabolism of ammonia and amino  acids in patients with fulminant hepatic failure. Gastroenterology 2001;121:1109-19
  • Strauss GI, Christiansen M, Møller K, Clemmesen JO, Larsen FS, Knudsen GM: S-100b and neuron-specific enolase as markers of cerebral dysfunction in patients with fulminant hepatic failure. Liver Transpl 2001;7:964-70
  • Strauss GI, Edvinsson L, Larsen FS, Møller K, Knudsen GM: Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure. Neuropeptides 2001;35:174-80
  • Sundgreen C, Larsen FS, Herzog TM, Knudsen GM, Boesgaard S, Aldershvile J. Autoregulation of cerebral blood flow in patients resuscitated from cardiac arrest. Stroke 2001;32:128-32.
  • Videbæk C, Toska K, Friberg L, Holm S, Angelo HR, Knudsen GM. In vivo measurement of haloperidol affinity to dopamine D2/D3 receptors by [123I]IBZM and single photon emission computed tomography. J Cereb Blood Flow Metab 2001;21:92-7
Books and book chapters
  • Strandgaard S, Paulson OB. Hypertension and brain. In: Anand MP, Billimoria AR, eds. Hypertension. An International Monograph 2001. India: IJCP Group, 2001. p. 138-42
  • Strandgaard S, Paulson OB. Management of hypertension with cerebrovascular disease. In: Anand MP, Billimoria AR, eds. Hypertension. An International Monograph 2001. India: IJCP Group, 2001. p. 271-3


Original publications in peer-reviewed journals (20)
  • Blinkenberg M, Rune K, Jensen CV, Ravnborg M, Kyllingsbæk S, Holm S, Paulson OB, Sørensen PS. Cortical cerebral metabolism correlates with MRI lesion load and cognitive dysfunction in MS. Neurology 2000;54:558-64
  • Gerlach C, Law I, Gade A, Paulson OB. Categorization and category effects in normal object recognition. A PET Study. Neuropsychologia 2000;38:1693-1703
  • Hanson LG,  Schaumburg K,  Paulson OB. Reconstruction strategy for echo planar spectroscopy and its application to partially undersampled imaging. Magn Reson Med 2000;44:412-7
  • Hugdahl K, Law I,Kyllingsbæk S, Brønnick K, Gade A, Paulson OB. Effects of attention on dichotic listening: An 15O-PET study. Hum Brain Mapping 2000;10:87-97
  • Høgh P, Oturai A, Schreiber K, Blinkenberg M, Jørgensen OS, Ryder L, Paulson OB, Sørensen PS, Knudsen GM. Apolipoprotein E and multiple sclerosis: impact of the epsilon-4 allele on susceptibility, clinical type and progression rate. Multiple Sclerosis 2000;6:226-30
  • Iida H, Law I, Pakkenberg B, Krarup-Hansen A, Eberl S, Holm S, Hansen AK, Gundersen HJG, Thomsen C, Svarer C, Ring P, Friberg L, Paulson OB. Quantitation of regional cerebral blood flow corrected for partial volume effect using O-15 water and PET: I. Theory, error analysis, and stereologic comparison. J Cereb Blood Flow Metab 2000;20:1237-51
  • Kofoed KF, Hansen PR, Holm S, Hove JD, Chen K, Jin W, Jensen M, Iida H, Hesse B, Svendsen J, Kelbæk H. Regional myocardial oxygen consumption estimated by carbon-11 acetate and positron emission tomography before and after repetitive ischemia. J Nucl Cardiol 2000;7:228-34
  • Kruuse C, Jacobsen TB, Lassen LH, Thomsen LL, Hasselbalch SG, DigePetersen H, Olesen J. Dipyridamole dilates large cerebral arteries concomitant to headache induction in healthy subjects. J Cereb Blood Flow Metab 2000;20:1372-9
  • Kruuse C, Jacobsen TB, Thomsen LL, Hasselbalch SG, Frandsen EK, DigePetersen H, Olesen J.   Effects of the non-selective phosphodiesterase inhibitor pentoxifylline on regional cerebral blood flow and large arteries in healthy subjects. Eur J Neurol 2000;7:629-38
  • Larsen A, Bundesen C, Kyllingsbæk S, Paulson OB, Law I. Brain activation during mental transformation of size. J Cogn Neurosci 2000;12:763-74
  • Larsen FS, Strauss G, Knudsen GM, Herzog TM, Hansen BA, Secher NH. Cerebral perfusion, cardiac output, and arterial pressure in patients with fulminant hepatic failure. Crit Care Med 2000;28:996-1000
  • Law I, Iida H, Holm S, Nour S, Rostrup E, Svarer C, Paulson OB. Quantitation of regional cerebral blood flow corrected for partial volume effect using O-15 water and PET: II. Normal values and gray matter blood flow response to visual activation. J Cereb Blood Flow Metab 2000;20:1252-63
  • Møller K, Larsen FS, Qvist J, Wandall JH, Knudsen GM, Gjørup IE, Skinhøj P. Dependency of cerebral blood flow on mean arterial pressure in patients with acute bacterial meningitis. Crit Care Med 2000;28:1027-32
  • Møller K, Høgh P, Larsen FS, Strauss GI, Skinhøj P, Sperling BK, Knudsen GM. Regional cerebral blood flow during hyperventilation in patients with acute bacterial meningitis. Clin Physiol 2000;5:399-410
  • Møller K, Skinhøj P, Knudsen GM, Larsen FS: Effect of short-term hyperventilation on cerebral blood flow autoregulation in patients with acute bacterial meningitis. Stroke 2000;31:1116-22
  • Nour S, Svarer C, Kristensen JKI, Paulson OB, Law I. Cerebral activation during micturition in normal men. Brain 2000;123:781-9
  • Pinborg LH, Videbæk C, Knudsen GM, Swahn C-G, Halldin C, Friberg L, Paulson OB, Lassen NA. Dopamine D2 receptor quantification in extrastriatal brain regions using [123I]Epidepride with bolus/infusion. Synpase 2000;36:322-9
  • Rostrup E, Law I, Blinkenberg M, Larsson HBW, Born AP, Holm S, Paulson OB. Regional differences in the CBF and BOLD responses to hypercapnia: A combined PET and fMRI study. NeuroImage 2000;11:87-97
  • Sargent PA, Kjær KH, Bench CJ, Rabiner EA, Messa C, Meyer J, Gunn RN, Grasby PM, Cowen PJ. Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment. Arch Gen Psychiatry 2000;57:174-80
  • Videbæk C, Toska K, Scheideler MA, Paulson OB, Knudsen GM. SPECT tracer [123I]IBZM has similar affinity to dopamine D2 and D3 receptors. Synapse 2000;38:338-42
Books and book chapters
  • Gjedde A, Hansen SB, Knudsen GM, Paulson OB, eds. Physiological imaging of the brain with PET. San Diego: Academic Press 2000
  • Iida H, Law I, Pakkenberg B, Eberl S, Paulson OB. Quantitation of regional cerebral blood flow corrected for partial volume effect using O-15 water and PET. In: Tamaki N, Tsukamoto E., Kuge Y, Katoh C. and Morita K, eds. Positron Emission Tomography in the Millennium. Elsevier Science. 2000; 245
  • Knudsen GM, Paulson OB. Neurologiske og neuromuskulære sygdomme. I: Lorenzen I, Bendixen G, Hansen NE, eds. Medicinsk Kompendiums Lommebog, 2. udgave. København: Nyt Nordisk Forlag Arnold Busck A/S, 2000:496-538
  • Spence JD, Paulson OB, Strandgaard S. Hypertension and stroke. In: Messerli FH, ed. The ABCs of antihypertensive therapy. New York: Lippincott Williams & Wilkins, 2000:279-96


Original publications in peer-reviewed journals (14)
  • Blinkenberg M, Jensen CV, Holm S, Paulson OB, Sørensen PS. A longitudinal study of cerebral glucose metabolism, MRI, and disability in patients with MS. Neurology 1999;53:149-53
  • Gerlach C, Law I, Gade A, Paulson OB. Perceptual differentiation and category effects in normal object recognition. A PET study. Brain 1999;122:2159-70
  • Hansen LK, Larsen J, Nielsen FÅ, Strother SC, Rostrup E, Savoy R, Lange N, Sidtis J, Svarer C, Paulson OB. Generalizable patterns in neuroimaging: How many principal components? NeuroImage 1999;9:534-44
  • Hasselbalch SG, Knudsen GM, Videbæk C, Pinborg LH, Schmidt JF, Holm S, Paulson OB. No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans.  Diabetes 1999;48:1915-21
  • Herholz K, Nordberg A, Salmon E, Perani D, Kessler J, Mielke R, Halber M, Jelic V, Almkvist O, Collette F, Alberoni M, Kennedy A, Hasselbalch S, Fazio F, Heiss W. Impairment of neocortical metabolism predicts progression in Alzheimer's disease. Dement Geriatr Cogn Disord. 1999 Nov-Dec;10(6):494-504
  • Hugdahl K, Brønnick K,Kyllingsbæk S, Law I, Gade A, Paulson OB. Brain activation during dichotic presentations of consonant-vowel and musical instrument stimuli: a 15O-PET study. Neuropsychologia 1999;37:431-40
  • Høgh P, Waldemar G, Knudsen GM, Bruhn P, Mortensen H, Wildschiødtz G, Bech RA, Juhler M, Paulson OB. A multidisciplinary memory clinic in a neurological setting: diagnostic evaluation of 400 consecutive patients. Eur J Neurol 1999;6:279-88
  • Kim S, Rostrup E, Larsson HBW, Ogawa S, Paulson OB. Determination of relative CMRO2 from CBF and BOLD changes: Significant increase of oxygen consumption rate during visual stimulation. Magn Reson Med 1999;41:1152-61
  • Kjems U, Strother SC, Anderson J, Law I, Hansen LK. Enhancing the multivariate signal of [15O] water PET studies with a new nonlinear neuroanatomical registration algorithm. IEEE Transactions on Medical Imaging 1999;18:306-19
  • Knudsen GM, Hasselbalch SG, Hertz MM, Paulson OB. High dose insulin does not increase glucose transfer across the blood-brain barrier in humans: a re-evaluation. Eur J Clin Invest 1999;29(8):687-91
  • Linde R, Schmalbruch IK, Paulson OB, Madsen PL. The Kety-Schmidt technique for repeated measurements of global cerebral blood flow and metabolism in the conscious rat. Acta Physiol Scand 1999;165:395-401
  • Nowak M, Olesen KS, Law I, Holm S, Paulson OB, Secher NH. Command-related distribution of regional cerebral blood flow during attempted handgrip. J Appl Physiol 1999;86(3):819-24
  • Strauss GI, Høgh P, Møller K, Knudsen GM, Hansen BA, Larsen FS. Regional cerebral blood flow during mechanical hyperventilation in patients with fulminant hepatic failure. Hepatology 1999;30:1368-1373
  • Videbæk C, Ott P, Paulson OB, Knudsen GM. Blood-brain barrier transport and protein binding of flumazenil and iomazenil in the rat: Implications for neuroreceptor studies. J Cereb Blood Flow Metab 1999;19:948-55
Books and book chapters
  • Knudsen GM, Hasselbalch SG, Paulson OB. Induction of carrier mediated transport across the human blood-brain barrier. In: Paulson OB, Knudsen GM, Moos T, eds. Brain Barrier Systems. Copenhagen: Munksgaard 1999:321-38
  • Knudsen GM, Paulson OB. In: Lorenzen I, Bendixen G, Hansen NE, eds. Medicinsk Kompendium. Multiple Choice. Copenhagen: Nyt Nordisk Forlag 1999:164-73
  • Paulson OB, Boysen G, Krarup C, Knudsen GM, Sørensen PS. Neurologi. I: Lorenzen I, Bendixen G, Hansen NE, eds. Medicinsk Kompendium, 15. udgave. København: Nyt Nordisk forlag Arnold Busck A/S 1999:2481-2677
  • Paulson OB, Knudsen GM, Moos T, eds. Brain Barrier Systems. Alfred Benzon Symposium 45. Copenhagen: Munksgaard 1999:1-524
  • Strandgaard S, Paulson OB. Hypertension and brain. In: Anand MP, Billimoria AR, eds. Hypertension - An international monograph 2000. New Delhi: IJCP Group of Publications, 1999:133-8
  • Strandgaard S, Paulson OB. Management of hypertension with cerebrovascular disease. In: Anand MP, Billimoria AR, eds. Hypertension - An international monograph 2000. New Delhi: IJCP Group of Publications, 1999:233-6
  • Sørensen PS, Paulson OB, Gjerris F. Nervesystemets sygdomme. 2. udgave. København: FADL, 1999


Original publications in peer-reviewed journals (7)
  • Hasselbalch SG, Madsen PL, Knudsen GM, Holm S, Paulson OB. Calculation of the FDG lumped constant by simultaneous measurements of global glucose and FDG metabolism in humans. J Cereb Blood Flow Metab 1998;18:154-60
  • Jernigan T, Ostergaard AL, Law I, Svarer C, Gerlach C, Paulson OB. Brain activation during word identification and word recognition. Neuroimage 1998;8:93-105
  • Lassen U, Andersen P, Daugaard G, Holm S, Jensen M, Svarer C, Poulsen HS, Paulson OB. Metabolic and hemodynamic evaluation of brain metastases from small cell lung cancer with positron emission tomography. Clin Cancer Res 1998;4:2591-7
  • Law I, Svarer C, Rostrup E, Paulson OB. Parieto-occipital cortex activation during self-generated eye movements in the dark. Brain 1998;121:2189-2200
  • Madsen PL, Linde R, Hasselbalch SG, Paulson OB, Lassen NA. Activation-induced resetting of cerebral oxygen and glucose uptake in the rat. J Cereb Blood Flow Metab 1998;18:742-8
  • Strauss G, Hansen BA, Knudsen GM, Larsen FS. Hyperventilation restores cerebral blood flow autoregulation in patients with acute liver failure. J Hepatol 1998;28:199-203
  • Vraamark T, Waldemar G, Paulson OB. Differential effects of migraine drugs on cerebral blood flow. Cephalalgia 1998;18:306-12
Books and book chapters
  • Ardekani BA, Strother SC, Anderson JR, Law I, Paulson OB, Kanno I, Rottenberg DA. On the detection of activation patterns using principal components analysis. In: Carson RE, Daube-Witherspoon ME,Herscovitch P, eds. Quantitative functional brain imaging with positron emission tomography. San Diego: Academic Press 1998:253-7
  • Baron JC (chairman), Lenzi GL, Brücke T, Frackowiak R, Heiss WD, Pantano P, Paulson OB, Rossini PM, Schoenen J, Touboul PJ, Vion-Dury J, Von Kummer R. European Federation of Neurological Societies Task Force on Neuroimaging: Neuroimaging in European academic neurology: present status and future organization. Eur J Neurol 1998;5:5-15
  • Knudsen GM, Paulson OB. Measurement of blood-brain barrier in humans using indicator diffusion. In: Pardridge WM, ed. Introduction to the blood-brain barrier. Methodology, biology and pathology. Cambridge: Cambridge University Press 1998:133-9
  • Olsen KS. The influence of ketanserin on cerebral hemodynamics - with special reference to neuroanesthesia. Dan Med Bull 1998;45:76-88
  • Paulson OB. Hjernens blodforsyning. Ugeskr Læger 1998:11:1612-13


Original publications in peer-reviewed journals (6)
  • Bay-Hansen J, Ravn T, Knudsen GM. Application of interhemispheric index for transcranial doppler sonography velocity measurements and evaluation of recording time. Stroke 1997;28:1009-14
  • Bergström KA, Halldin C, Yu MX, Swahn C-G, Åkerman KK, Hiltunen J, Tiihonen J, Kuikka J, Lassen N, Videbæk C, Farde L. The metabolite pattern of [123I]epidepride in human plasma determined with a gradient HPLC method. J Label Comp Radiopharm 1997;40:151-3
  • Law I, Svarer C, Holm S, Paulson OB. The activation pattern i n normal humans during suppression, imagination and performance of saccadic eye movements. Acta Physiol Scand 1997;161:419-34
  • Mørch N, Hansen LK, Strother SC, Svarer C, Rottenberg DA, Lautrup B, Savoy R, Paulson OB. Nonlinear versus linear models in functional neuroimaging: Learning curves and generalization crossover. In: Duncan J, Gindi G, eds. Information Processing in Medical Imaging. Berlin Heidelberg: Springer Verlag. Lecture notes in computer science 1997;1230:259-70
  • Vraamark T, Waldemar G, Edvinsson L, Paulson OB. Differential effects of increasing doses of alfa-trinositol on cerebral blood flow autoregulation. Pharmacol & Toxicol 1997;80:38-43Christensen R, Marcussen AB, Wörtwein G, Knudsen GM, Aznar S. Aβ(1-42)injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT2A levels. Exp Neurol 2008;210:164-71
Books and book chapters
  • Lassen NA, Paulson OB. Indomethacin nedsætter hjernegennemblødningen og det intrakranielle tryk. Ugeskr Læger 1997;159:4249
  • Paulson OB, Hasselbalch SG. Blood-brain barrier transport of glucose: adaptation to changes in blood glucose levels. Nutr Metab Cardiovasc Dis 1997;7:217-24
  • Paulson OB, Lassen NA. SPECT og PET i neurobiologien. Nord Med 1997;112:356-60
  • Paulson OB, Lassen NA. SPECT og PET i neurobiologien. Ugeskr Læger 1997;159/16:2351-5
  • Strandgaard S, Paulson OB. The cerebral circulation in hypertension. In: Zanchetti A, Mancia G, eds. Pathophysiology of hypertension. Amsterdam: Elsevier Science 1997;17:265-94
  • Waldemar G, Høgh P, Paulson OB. Functional brain imaging with SPECT in the diagnosis of Alzheimer’s disease. Intern Psychoger 1997/Suppl 1;9:223-7


Original publications in peer-reviewed journals (10)
  • Andersen AR, Hansen BR, Høgenhaven H, Herning M, Paulson O, Dam M. Interictal SPECT of rCBF is of clinical utility in the preoperative evaluation of patients with partial epilepsy. Epilepsy Res 1996;25:41-50
  • Blinkenberg M, Bonde C, Holm S, Svarer C, Andersen J, Paulson OB, Law I. Rate dependence of regional cerebral activation during performance of a repetitive motor task: a PET study. J Cereb Blood Flow Metab 1996;16:794-803
  • Blinkenberg M, Rune K, Jønsson A, Holm S, Jensen CV, Paulson OB, Sørensen PS. Cerebral metabolism in a case of multiple sclerosis with acute mental disorder. Acta Neurologica Scandinavica 1996;94:310-3
  • Boller F, Duyckaerts C, Paulson OB, Vorstrup S, Soelberg Sørensen P. Prion related diseases and Creutzfeldt-Jakob disease (subacute spongiform encephalopathy). Eur J Neurol 1996;3:485-6
  • EU concerted action on functional imaging: Poline J-B, Vandenberghe R, Holmes AP, Friston KJ, Frackowiak RSJ et al. Reproducibility of PET activation studies: Lessons from a multi-center European experiment. Neuroimage 1996;4:34-54
  • Hasselbalch SG, Madsen PL, Hageman LP, Olsen KS, Justesen N, Holm S, Paulson OB. Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia. Am J Physiol 1996;270 (Endocrinol Metab 33):E746-51
  • Hasselbalch SG, Knudsen GM, Holm S, Hageman LP, Capaldo B, Paulson OB. Transport of d-glucose and 2-fluorodeoxyglucose across the blood-brain barrier in humans. J Cereb Blood Flow Metabol 1996;16:659-66
  • Hasselbalch S, Knudsen GM, Toft PB, Høgh P, Tedeschi E, Holm S, Videbæk C, Henriksen O, Lou HC, Paulson OB. Cerebral glucose metabolism is decreased in white matter changes in patients with phenylketonuria. Pediatr Res 1996;40:21-4
  • Larsen FS, Hansen BA, Ejlersen E, Secher NH, Clemmesen JO, Tygstrup N, Knudsen GM. Cerebral blood flow, oxygen metabolism and transcranial Doppler sonography during high-volume plasmapheresis in fulminant hepatic failure. Eur J Gastroenterol Hepatol 1996;8:261-65
  • Larsen FS, Hansen BA, Pott F, Ejlersen E, Secher NH, Paulson OB, Knudsen GM. Dissociated cerebral vasoparalysis in acute liver failure. J Hepatol 1996;25:145-151
Books and book chapters
  • Gjerris F, Paulson OB. Centralnervesystemets kirurgiske sygdomme. I: Hald T, Stadil F, eds. Kirurgisk Kompendium. 2. udgave. København: Nyt Nordisk Forlag Arnold Busck 1996:355-402
  • Gjerris F, Paulson OB. Degenerative osteoartrotiske sygdomme i columna, diskusprolaps og kirurgiske sygdomme i det perifere nervesystem. I: Hald T, Stadil F, eds. Kirurgisk Kompendium, 2. udgave. København: Nyt Nordisk Forlag Arnold Busck 1996:433-59
  • Knudsen GM, Paulson OB. Neurologiske og neuromuskulære sygdomme. I: Lorenzen I, Bendixen G, Hansen NE, eds. Medicinsk Kompendiums Lommebog. København: Nyt Nordisk Forlag Arnold Busck A/S, 1996:415-52
  • Paulson OB. De neurologiske artikler. I: Holm-Nielsen N, ed. Klinisk Ordbog. København: Munksgaard 1996
  • Paulson OB. Billeddiagnostik af hjernens funktion. Lundbeckfonden "Årsberetning 1995" 1996:18-19
  • Paulson OB, Gjerris F, Sørensen PS, Juhler M. Klinisk neurologi og neurokirurgi. 2. udg. København: FADL, 1996
  • Strandgaard S, Paulson OB. Antihypertensive drugs and cerebral circulation. Eur J Clin Invest 1996;26-625-30
  • Vorstrup S, Paulson OB. Prionsygdomme. Ugeskr Læger 1996;158:4061
  • Vorstrup S, Haase J, Waldemar G, Andersen A, Schmidt J, Paulson OB. EC-IC bypass in patients with chronic hemodynamic insufficiency. Acta Neurol Scand 1996/Suppl 166:79-81. Kongresmeddelelser
    European concerted action on functional imaging, Cologne, Copenhagen, Düsseldorf, Essen, Groeningen Leuven, Liege, London, Lyon, Milan, Orsay, Stockholm (Rapporteur: J-B. Poline). Analyzing a European PET activation study. Lessons from a multi-center experiment. In: Myers R, Cunningham V, Bailey D, Jones T, eds. Quantification of brain function using PET. London: Academic Press 1996:372-7
  • Holm S, Law I, Paulson OB. 3D PET activation studies with an H215O bolus injection. In: Myers R, Cunningham V, Bailey D, Jones T, eds. Quantification of brain function using PET. San Diego: Academic Press, 1996:93-7
  • Larsen J, Hansen LK, Svarer C, Ohlsson M. Design and regularization of neural networks: The optimal use of a validation set. In: Usui S et al., eds. Neural networks for signal processing VI. Piscataway, NJ: IEEE, 1996:62-71
  • Rostrup E, Law I, Blinkenberg M, Larsson HBW, Born P, Paulson OB. A combined PET and MRI study of human CBF in hypercapnia. Proceedings of the International Society for Magnetic Resonance in Medicine. Fourth International Meeting and Exhibition 1996, S1762
  • Svarer C, Law I, Holm S, Mørch N, Hasselbalch S, Hansen LK, Paulson OB. An artificial neural network approach to estimation of the regional glucose metabolism using PET. In: Myers R, Cunningham V, Bailey D, Jones T, eds. Quantification of brain function using PET. San Diego: Academic Press, 1996:271-6
  • Paulson OB, Knudsen GM. Comments on point: Counterpoint: Sympathetic activity does/does not influence cerebral blood flow. Role of a rudimentary sympathetic nervous system on cerebral blood flow. J Appl Physiol 2008;105:1371-2



This translational neuroscience programme will explore the most promising drug target for treatment of cognitive dysfunction: The nicotinic alpha7 acetylcholine (ACh) receptor (α7nAChR). The aim is to identify subpopulations of patients with cognitive dysfunction [i.e. diagnosed for Alzheimer's disease (AD) or schizophrenia (SCZ)] that will benefit from treatment with α7nAChR modulators. Our results, supported by the literature, suggest that only some patients will benefit from this treatment. Therefore, application of human model systems and selection of well-defined patient groups, based on their biomarker profiles, are instrumental to select the right compound(s) for future clinical trials. We hypothesize that the differential effects in patients are due to a) differences in the composition and expression of a α7nAChR duplicate hybrid gene acting as a dominant negative, and b) functional variability of the receptor is due to the presence of interacting proteins and peptides (i.e. β-amyloids) in the diseased brain.

The involved partners have a strong background in combining basic neuroscience, industrial drug-discovery, molecular brain imaging, biomarker discovery and clinical research. In this project we will take advantage of this translational approach and investigate the effects of α7nAChR positive modulators using human neuronal extracts, porcine/human stem cells, novel translational animal models, and transgenic animals. We will also screen for the presence, sequence, and copy number of the dominant negative CHRFAM7A gene in well-defined patient populations with cognitive disturbances. We will determine how synthetic amyloids and extracts of CSF samples from individual patients with dementia interact with the receptor.

Furthermore, we have discovered an α7nAChR radiotracer for brain imaging - 11C-NS14492 - and we will develop this tracer and the accompanying method in pigs with the intention of using it in human trials in the end of this programme. All together this is a focused translational project that within the 5 year period will help to define selected patient groups based on biomarkers
profiles and sensitivity to novel treatments of cognitive dysfunction.

See more at our home page:




Poul Hyttel
Department of Veterinary Clinical and Animal Sciences,
Faculty of Health and Medical Sciences, 
University of Copenhagen


Center for Neuropsychiatric Schizophrenia Research
Birte Glenthøj
Ndr. Ringvej
2600 Glostrup
Department of Health Science and Technology 
University of Aalborg

Jacek Lichota

Laboratory of Neurobiology
Biomedicine, Aalborg University
Fredrik Bajers Vej 3 B
9220 Aalborg Øst

Neurobiology Research Unit 
Jens D. Mikkelsen
The Neuroscience Centre
Rigshospitalet, building 6931
Copenhagen University Hospital
Blegdamsvej 9
2100 København Ø 

The Kennedy Center
Zeynep Tümer
Center for Anvendt Human Molekylærgenetik
Gl. Landevej 7
2600 Glostrup

Currently we have the following open positions:

Studentermedhjælper til hjælp ved MR-skanninger
Deadline: September 19, 2021.

Forskningsbioanalytiker eller -radiograf med erfaring inden for nuklearmedicin
Deadline: September 24, 2021.
Brug flg. link for at søge stillingen:

Health science IT data platform developer
Deadline: September 3rd, 2021.

Research year students:

Voluntary test persons:

  • If you would like to become a test person in one of our ongoing research projects, then click here.

More Articles ...

  1. Funding
  2. Contact
  3. About us


  • Research

    In this section you can read more about the different areas of NRU research and the ongoing projects as well as how to get enrolled as voluntary test person in one of our research projects.