Serotonergic modulation of cognition, emotion and brain activation in healthy volunteers (HC-SSRI project)

The HC-SSRI project is a double-blind placebo-controlled study of healthy individuals. Here, we evaluate how a three-week treatment with the drug selective serotonin reuptake inhibitor (SSRI) affects human’s cognition and emotions, as measured with functional magnetic resonance imaging (fMRI) and sophisticated neuropsychological testing (Cambridge Neuropsychological Test Automated Battery and EMOTICOM), and further affects synaptic plasticity measured with Positron Emission Tomography (PET). The project is a collaboration between NRU and Professor and cognition expert Barbara Sahakian and post doc Christelle Langley from The University of Cambridge, UK.

We have finished recruiting healthy controls for the project.