Prophylactic effects of psilocybin on chronic cluster headache (EPOCH)

Cluster headache is a debilitating primary headache disorder, where patients experience excruciating headache attacks up 8 times per day. Some patients respond poorly to preventive medication or experience unacceptable side-effects. Thus, there is a need for development of novel medication. In this project, we evaluate effects of thee doses of psilocybin (active compound in "magic mushrooms") on headache in 10 patients with chronic cluster headache. To better understand potential mechanisms of action, patients are also scanned with fMRI before and after the drug intervention. The findings will help determine, whether psilocybin is a viable option for further drug development in cluster headache and also elucidate effects on brain function.

The enrollment status in the project is displayed below: