Other Research Staff

Contact

Position:
Academic Employee, Pharmacology
Dept. Neurology and Neurobiology Research Unit,
Copenhagen University Hospital, Rigshospitalet,
Building 6931,
Blegdamsvej 9, DK-2100 Copenhagen, Denmark
3545 6706

Curriculum vitae

Scientific interests

Arafat holds a master’s degree in Pharmaceutical Sciences from The Faculty of Pharmaceutical Sciences, University of Copenhagen. In 2012, he obtained the PhD degree in pharmacology at the same university. His research activities have focused on chronic pain, anxiety and depression. It has been devoted on understanding the role and mechanisms of the tetrahydrobiopterin pathway in pain and affective disorders. The goal has been to identify new more efficacious and safer treatments for these debilitating conditions.

Today Arafat works as Academic Employee at NRU. His main responsibility is to conduct chemical analysis of radioligands and their metabolites, and to develop new methods to determine new tracers in biological samples.   

Biography

2019 - 

Academic Employee at the Neurobiology Research Unit

2016 - 2019 

Academic Employee at Asthma-Allergy Denmark, The Blue Label

2015 - 2016

Post.doc at Department of Drug Design and Pharmacology, Copenhagen University

2012 - 2015

Post.doc at Kennedy Center (Rigshospitalet) and Department of Drug Design and Pharmacology, Copenhagen University

2008 - 2012

PhD Scholarship at Kennedy Center and Department of Drug Design and Pharmacology, Copenhagen University

2008

Pharmacist at Jernbane Alle Apotek

2007 - 2008

Pharmacist at Danmarks Apotekerforening

2007

Pharmacist (temporary) at Grøndalsapotek

Publications

Peer-reviewed

Nasser A, Møller AT, Hellmund V, Thorberg SS, Jespersgaard C, Bjerrum OJ, Dupont E, Nachman GS, Lykkesfeldt J, Jensen TS, Møller LB. Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity. Pain. 2018, 159(6), 1012-1024.

Andreasen JT, Nasser A, Puntiverio MC, Sahlholt M, Bach A, Gynther M, Strømgaard K, Pickering DS. Effects of the dimeric PSD-95 inhibitor UCCB01-144 in models of pain and cognition. Eur J Pharmacol. 2016, 780, 166-173.

Nasser A, Ali S, Wilsbech S, Bjerrum OJ, Møller LB. Intraplantar injection of tetrahydrobiopterin induced nociception in mice. Neurosci. Lett. 2015, 584, 247-252 

Nasser A, Møller LB, Olesen JH, Konradsen LS, Andreasen JT. Anxiety- and depression-like phenotype of hph-1 mice deficient in tetrahydrobiopterin. Neurosci. Res. 2014. DOI: 10.1016/j.neures.2014.08.015                 

Nasser A, Møller LB. GCH1 gene variants, tetrahydrobiopterin and pain. Scand. J. Pain 2014, 5, 121-128

Nasser A, Bjerrum OJ, Heegaard AM, Møller AT, Larsen M, Dalbøge LS, Jensen TS, Møller LB. Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain. Mol Pain 2013. 9, 5

Andreasen JT, Bach A, Gynther M, Nasser A, Mogensen J, Strømgaard K, Pickering DS. UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: comparison with the NMDA receptor antagonist MK-801. Neuropharmacology 2013, 67, 193-200

Hansen RR, Nasser A, Falk S,  Baldvinsson SB, Ohlsson PH, Bahl JM, Jarvis MF, Ding M, Heegaard AM.  Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice. Eur. J. Pharmacol. 2012, 688, 27-34

Hansen RR, Nielsen CK, Nasser A, Thomsen SI, Eghorn LF, Pham Y, Schulenburg C, Syberg S, Ding M, Stojilkovic SS, Jorgensen NR, Heegaars AM. P2X7 receptor-deficient mice are susceptible to bone cancer pain. Pain 2011, 152, 1766-1776

Hald A, Ding M, Egerod K, Hansen RR, Konradsen D, Jørgensen SG, Atalay B, Nasser ABjerrum OJ, Heegaard AM: Differential effects of repeated low dose treatment with cannabinoid agonist WIN 55, 212-2 in experimental models of bone cancer pain and neuropathic pain.

Pharmacol. Biochem. Behav. 2008, 91, 38-46

Popular Science

Arafat Nasser, Ole J Bjerrum, Anne-Marie Heegaard, Lisbeth B. Møller: Genetik kan forudsige følsomhed for smerte. Lægemiddelforskning 2010. Danish text.

http://teol.ku.dk/abe/ansatte/?pure=files%2F32668400%2FGenetik_kan_forudsige.pdf.

Awards

2013 – Best oral speaker at the Danish Pharmocology Annual Meeting.

2011 – Best poster at the newSASP annual meeting.

2008 - 2016 – Grants from Aase & Ejnar Danielsens Foundation (twice), Augustinus Fonden, Brødrene Hartmanns Fond, Beckett-Fonden, The A.P. Møller Foundation for the Advancement of Medical Science, Oticon fonden, Pharmadanmarks studiefond (twice), Frabrikant Karl G. Andersens Fond and Lundbeck Foundation.