- Academic Employee, Pharmacology
Arafat holds a master’s degree in Pharmaceutical Sciences from The Faculty of Pharmaceutical Sciences, University of Copenhagen. In 2012, he obtained the PhD degree in pharmacology at the same university. His research activities have focused on chronic pain, anxiety and depression. It has been devoted on understanding the role and mechanisms of the tetrahydrobiopterin pathway in pain and affective disorders. The goal has been to identify new more efficacious and safer treatments for these debilitating conditions.
Today Arafat works as Academic Employee at NRU. His main responsibility is to conduct chemical analysis of radioligands and their metabolites, and to develop new methods to determine new tracers in biological samples.
Academic Employee at the Neurobiology Research Unit
2016 - 2019
Academic Employee at Asthma-Allergy Denmark, The Blue Label
2015 - 2016
Post.doc at Department of Drug Design and Pharmacology, Copenhagen University
2012 - 2015
Post.doc at Kennedy Center (Rigshospitalet) and Department of Drug Design and Pharmacology, Copenhagen University
2008 - 2012
PhD Scholarship at Kennedy Center and Department of Drug Design and Pharmacology, Copenhagen University
Pharmacist at Jernbane Alle Apotek
2007 - 2008
Pharmacist at Danmarks Apotekerforening
Pharmacist (temporary) at Grøndalsapotek
Nasser A, Møller AT, Hellmund V, Thorberg SS, Jespersgaard C, Bjerrum OJ, Dupont E, Nachman GS, Lykkesfeldt J, Jensen TS, Møller LB. Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity. Pain. 2018, 159(6), 1012-1024.
Andreasen JT, Nasser A, Puntiverio MC, Sahlholt M, Bach A, Gynther M, Strømgaard K, Pickering DS. Effects of the dimeric PSD-95 inhibitor UCCB01-144 in models of pain and cognition. Eur J Pharmacol. 2016, 780, 166-173.
Nasser A, Ali S, Wilsbech S, Bjerrum OJ, Møller LB. Intraplantar injection of tetrahydrobiopterin induced nociception in mice. Neurosci. Lett. 2015, 584, 247-252
Nasser A, Møller LB, Olesen JH, Konradsen LS, Andreasen JT. Anxiety- and depression-like phenotype of hph-1 mice deficient in tetrahydrobiopterin. Neurosci. Res. 2014. DOI: 10.1016/j.neures.2014.08.015
Nasser A, Møller LB. GCH1 gene variants, tetrahydrobiopterin and pain. Scand. J. Pain 2014, 5, 121-128
Nasser A, Bjerrum OJ, Heegaard AM, Møller AT, Larsen M, Dalbøge LS, Jensen TS, Møller LB. Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain. Mol Pain 2013. 9, 5
Andreasen JT, Bach A, Gynther M, Nasser A, Mogensen J, Strømgaard K, Pickering DS. UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: comparison with the NMDA receptor antagonist MK-801. Neuropharmacology 2013, 67, 193-200
Hansen RR, Nasser A, Falk S, Baldvinsson SB, Ohlsson PH, Bahl JM, Jarvis MF, Ding M, Heegaard AM. Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice. Eur. J. Pharmacol. 2012, 688, 27-34
Hansen RR, Nielsen CK, Nasser A, Thomsen SI, Eghorn LF, Pham Y, Schulenburg C, Syberg S, Ding M, Stojilkovic SS, Jorgensen NR, Heegaars AM. P2X7 receptor-deficient mice are susceptible to bone cancer pain. Pain 2011, 152, 1766-1776
Hald A, Ding M, Egerod K, Hansen RR, Konradsen D, Jørgensen SG, Atalay B, Nasser A, Bjerrum OJ, Heegaard AM: Differential effects of repeated low dose treatment with cannabinoid agonist WIN 55, 212-2 in experimental models of bone cancer pain and neuropathic pain.
Pharmacol. Biochem. Behav. 2008, 91, 38-46
Arafat Nasser, Ole J Bjerrum, Anne-Marie Heegaard, Lisbeth B. Møller: Genetik kan forudsige følsomhed for smerte. Lægemiddelforskning 2010. Danish text.
2013 – Best oral speaker at the Danish Pharmocology Annual Meeting.
2011 – Best poster at the newSASP annual meeting.
2008 - 2016 – Grants from Aase & Ejnar Danielsens Foundation (twice), Augustinus Fonden, Brødrene Hartmanns Fond, Beckett-Fonden, The A.P. Møller Foundation for the Advancement of Medical Science, Oticon fonden, Pharmadanmarks studiefond (twice), Frabrikant Karl G. Andersens Fond and Lundbeck Foundation.