Martin Nørgaard

Visiting Scientists and Associated Researchers

Contact

Martin Nørgaard
Position:
Post Doc
Dept. Neurology and Neurobiology Research Unit,
Copenhagen University Hospital, Rigshospitalet,
Building 8057,
Blegdamsvej 9, DK-2100 Copenhagen, Denmark
3545 6718

Curriculum vitae

Scientific interests:

My main research focus is on medical image processing (PET, MRI, DWI), advanced signal processing and machine learning. More specifically, I am very interested in the development of advanced statistical models, and how these models can be applied/adapted in order to draw inferences on given hypotheses. At the Neurobiology Research Unit I am mainly involved in the implementation of a variety of statistical and computational analyses to allow for inference on the complex serotonin transporter (5-HTT) modulation and how choice of preprocessing may influence data-driven metrics of prediction and reproducibility.

Biography:

2019 -  Post Doc at the Neurobiology Research Unit
2016 - 2019 PhD student at the Neurobiology Research Unit
2015 - 2016 Research Assistant at the Neurobiology Research Unit
2013 - 2015 MSc in Medicine and Technology, Technical University of Denmark, DTU
2010 - 2013 BSc in Medicine and Technology, Technical University of Denmark, DTU

Awards:

  • Young Researcher of the Year at Rigshospitalet 2017 (FYF) - 3rd place (grant of 1,000 USD) “Brain Networks involved in Seasonal Affective Disorder: A Neuroimaging PET Study of the Serotonin Transporter”
  • Lundbeckfonden travel stipend 2017 – Visiting PhD student at the MGH/Harvard-MIT Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts, USA (grant of 10,000 USD)
  • University of Copenhagen travel stipend 2017 - Visiting PhD student at the MGH/Harvard-MIT Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts, USA (grant of 5,500 USD)
  • Rigshospitalets Jubilæumsfond travel stipend 2017 – attending the annual Organization for Human Brain Mapping (OHBM) meeting in Vancouver, Canada (grant of 600 USD)
  • Lundbeckfonden travel stipend 2018 – attending the 8th International Workshop on Pattern Recognition In NeuroImaing (PRNI) in Singapore, Singapore (grant of 1,250 USD)
  • Lundbeckfonden travel stipend 2019 – attending the 22nd international conference on Medical Image Computing and Computer Assisted Interventions (MICCAI) in Shenzhen, China (grant of 2,800 USD)


Publications:

Peer-reviewed conference proceedings:
  1. Nørgaard M, Ganz M, Svarer C, Beliveau V, Fisher PM, Mc Mahon B, Greve DN, Strother SC, Knudsen GM. Estimation of Regional Seasonal Variations in SERT-levels using the FreeSurfer PET pipeline: a reproducibility study. Proceedings of the MICCAI workshop on Computational Methods for Molecular Imaging, Munich, 2015, pp. 1-12. DOI: 10.13140/RG.2.1.4365.7688
  2. Nørgaard M, Greve DN, Svarer C, Strother SC, Knudsen GM, Ganz M. The Impact of Preprocessing Pipeline Choice in Univariate and Multivariate Analyses of PET Data. Pattern Recognition in Neuroimaging (PRNI), Singapore, 2018, pp. 1-4. DOI: 10.1109/PRNI.2018.8423962
  3. Nørgaard M, Ozenne B, Svarer C, Frokjaer VG, Schain M, Strother SC, Ganz M. Preprocessing, Prediction, and Significance. Framework and Application to Brain Imaging. Springer Nature Switzerland AG 2019 D. Shen et al. (Eds.): MICCAI 2019, LNCS 11767, pp. 1–9, 2019. DOI: 10.1007/978-3-030-32251-9_22
Peer-reviewed journal papers:
  1. Rasmussen JH, Nørgaard M, Hansen AE, Vogelius IR, Aznar MC, Johannesen HH, Costa J, Kjær A, Højgaard L, Specht L, Fischer BM. Feasibility of multiparametric imaging with PET/MR in head and neck squamos cell carcinoma. Journal of Nuclear Medicine, 2017: 58(1): pp. 69-74. DOI: 10.2967/jnumed.116.180091
  2. Deen M, Hansen HD, Hougaard A, da Cunha-Bang S, Nørgaard M, Svarer C, Keller SH, Thomsen C, Ashina M, Knudsen GM. Low 5-HT1B receptor binding in the migraine brain: A PET study. Cephalalgia. 2018 Mar;38(3):519-527. DOI: 10.1177/0333102417698708
  3. Nørgaard M, Ganz M, Svarer C, Fisher PM, Churchill NW, Beliveau V, Grady C, Strother SC, Knudsen GM. Brain Networks Implicated in Seasonal Affective Disorder: A Neuroimaging PET Study of the Serotonin Transporter. Frontiers in Neuroscience | Brain Imaging Methods, November 2017. DOI: 10.3389/fnins.2017.00614
  4. Deen M, Hansen HD, Hougaard A, Nørgaard M, Eiberg H, Lehel S, Ashina M, Knudsen GM. High brain serotonin levels in migraine between attacks: A 5-HT4 receptor binding PET study. Neuroimage: Clinical 18 (2018); 97-102. DOI: 10.1016/j.nicl.2018.01.016
  5. Nørgaard M, Ganz M, Svarer C, Feng L, Ichise M, Lanzenberger R, Lubberink M, Parsey RV, Politis M, Rabiner EA, Slifstein M, Sossi V, Suhara T, Talbot PS, Turkheimer F, Strother SC, Knudsen GM. Cerebral Serotonin Transporter Measurements with [11C]DASB: A Review on Acquisition and Preprocessing across 21 PET Centres. Journal of Cerebral Blood Flow and Metabolism, 2019 Feb;39(2):210-222. DOI: 10.1177/0271678X18770107
  6. Mc Mahon B, Nørgaard M, Svarer C, Andersen SB, Madsen MK, Baare W, Madsen J, Frokjaer VG, Knudsen GM. Seasonality-resilient individuals downregulate their cerebral 5-HT transporter binding in winter - A longitudinal combined 11C-DASB and 11C-SB207145 PET study. European Neuropsychopharmacology, 2018, Oct;28(10):1151-1160. DOI: 10.1016/j.euroneuro.2018.06.004
  7. Nørgaard M, Ganz M, Svarer C, Frokjaer VG, Greve DN, Strother SC, Knudsen GM. (2019). Optimization of preprocessing strategies in Positron Emission Tomography (PET) neuroimaging: A [11C]DASB PET study. NeuroImage, 2019, Oct;199:466–479. DOI: 10.1016/j.neuroimage.2019.05.055
  8. Nørgaard M, Ganz M, Svarer C, Frokjaer VG, Greve DN, Strother SC, Knudsen GM. Different Preprocessing Strategies Lead to Different Conclusions: A [11C]DASB-PET Reproducibility Study. Journal of Cerebral Blood Flow and Metabolism, Accepted, Sept. 2019. DOI: 10.1177/0271678X19880450
Abstracts:
  1. Engberg AME, Hansen AE, Langer SW, Johannesen HH, Langer NH, Nørgaard M, Löfgren J, Keller SH, Højgaard L, Kjær A, Fischer BM. Multiparametric characterization of early tumour response using PET/MR in patients with lung cancer using a voxelwise analysis. European Association of Nuclear Medicine (EANM), 2015.
  2. Deen M, Hansen HD, Hougaard A, da Cunha-Bang S, Nørgaard M, Svarer C, Keller SH, Thomsen C, Ashina M, Knudsen GM. Low 5-HT1B receptor binding in the migraine brain: A PET study. EHMTIC in Glasgow, September 2016.
  3. Mc Mahon B, Nørgaard M, Svarer C, Andersen SB, Madsen MK, Baare W, Madsen J, Frokjaer VG, Knudsen GM. Individuals resilient to seasonal affective disorder downregulate their cerebral serotonin transporter binding in winter. Neuro Receptor Mapping (NRM), Boston MA, 2016.
  4. Nørgaard M, Ganz M, Svarer C, Fisher PM, Churchill NW, Beliveau V, Grady C, Strother SC, Knudsen GM. Brain Networks Implicated in Seasonal Affective Disorder: A Neuroimaging PET Study of the Serotonin Transporter. Organization for Human Brain Mapping (OHBM), Vancouver, Canada, 2017.
  5. Mc Mahon B, Nørgaard M, Svarer C, Andersen SB, Madsen MK, Baare W, Madsen J, Frokjaer VG, Knudsen GM. Seasonality-resilient individuals downregulate their cerebral serotonin transporter binding in winter while 5-HT levels appear unchanged. World Federation of Societies of Biological Psychiatry, Copenhagen, Denmark, 2017.
  6. Nørgaard M, Ganz M, Svarer C, Greve DN, Strother SC, Knudsen GM. The Impact of Preprocessing Pipeline Choice on Serotonin Transporter Measurements. Neuro Receptor Mapping (NRM), London, UK, 2018.
  7. Ganz M, Nørgaard M, Beliveau V, Greve DN, Knudsen GM. False positive rates in positron emission tomography. Neuro Receptor Mapping (NRM), London, UK, 2018.
  8. Nørgaard M, Ganz M, Svarer C, Frokjaer VG, Greve DN, Strother SC, Knudsen GM. The Impact of Different Preprocessing Strategies: A [11C]DASB-PET Case. BrainPET, Yokohama, Japan, Jan 2019. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 39, 596-597.
  9. Lange D, Tejada IM, Xiong M, Hillebrand B, Nørgaard M, Baerentzen S, Shalgunov V, L’Estrade ET, Keller SH, Herth MM, Svarer C, Palner M. High-throughput rat brain PET imaging and automatic spatial normalization of the dopamine D2/3 receptor ligand [18F]Fallypride. BrainPET, Yokohama, Japan, Jan 2019. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 39, 588-589.
  10. Nørgaard M, Ganz M, Svarer C, Frokjaer VG, Greve DN, Strother SC, Knudsen GM. Different Preprocessing Strategies Lead to Different Conclusions: A [11C]DASB-PET Reproducibility Study. European College of Neuropharmacology (ECNP), Copenhagen, Denmark, Sept. 2019.