Hanne D. Hansen
- Instructor, Harvard/MGH
I am a molecular biologist with a special interest in neuroimaging and in vivo pharmacology. My primary research area is using simultaneous PET/MR (also called hybrid PET/MR) to functionally characterize novel and existing drugs for the serotonergic system. This technique allows for the characterization of the brain network effects of these drugs, which gives us valuable mechanistic insight into the therapeutic effects of these drugs.
Alongside my preclinical and clinical projects, I am also involved in various projects concerning the more advanced data analysis of these PET/MR scans.
My work also involves collaborating with medicinal chemists and radiochemists to develop new PET radiotracers for various targets in the central nervous system. These PET radiotracers are valuable tools in the drug development process.
2020 - Instructor at Harvard Medical School and the MGH/HST Martinos Center for Biomedical Imaging, Boston, USA 2019 - Research Fellow at the MGH/HST Martinos Center for Biomedical Imaging, Boston, USA 2017 - Junior Group Leader, Neurobiology Research Unit 2013 - 2016 Post.doc, Neurobiology Research Unit 2010 - 2013 Ph.D., Neurobiology Research Unit, University of Copenhagen 2009 - 2010 Research assistant, Hertie Institiute of Clinical Brain Research, Tübingen, Germany 2004 - 2009 B.Sc. and M.Sc. in Molecular biology, Aarhus University
My full list of scientific publications can be accessed using the following PubMed link.
- Hansen HD, Constantinescu CC, Barret O, Herth MM, Magnussen JH, Lehel S, Dyssegaard A, Colomb J, Billard T, Zimmer L, Tamagnan G, Knudsen GM. Evaluation of [18F]2FP3 in pigs and non-human primates. J Labelled Comp Radiopharm. 2018
- Johansen A, Hansen HD, Lehel S, Leth-Petersen S, Kristensen JL, Gillings N, Knudsen GM. The importance of small polar radiometabolites in molecular neuroimaging: A PET study with [11C]Cimbi-36 labeled in two positions. J Cereb Blood Flow Metab. 2018;38(4):659-668
- Deen M, Hougaard A, Hansen HD, Svarer C, Eiberg H, Lehel S, Knudsen GM, Ashina M. Migraine is associated with high brain 5-HT levels as indexed by 5-HT4 receptor binding. Cephalalgia. 2018
- Hansen HD, Mandeville JB, Sander CY, Hooker JM, Catana C, Rosen BR, Knudsen GM. Functional characterization of 5-HT1B receptor drugs in non-human primates using simultaneous PET-MR. J Neurosci. 2017 Nov 1;37(44):10671-10678
- Jensen CH, Hansen HD, Bay T, Vogensen SB, Lehel S, Thiesen L, Bundgaard C, Clausen RP, Knudsen GM, Herth MM, Wellendorph P, Frøund P. Radiosynthesis and Evaluation of [11C]-3-Hydroxycyclopent-1-enecarboxylic Acid ([11C]HOCPCA) as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid (GHB) Binding Sites. ACS Chemical Neuroscience. 2017 Jan 18;8(1):22-27
- Ganz-Benjaminsen M, Feng L, Hansen HD, Beliveau V, Svarer C, Knudsen GM, Greve D. Cerebellar heterogeneity and its impact on PET data quantification of 5-HT receptor radioligands. J Cereb Blood Flow Metab. 2017 Sep;37(9):3243-3252
- Mandeville JB, Sander CY, Wey HY, Hooker JM, Hansen HD, Svarer C, Knudsen GM, Rosen BR. A regularized full reference tissue model for PET neuroreceptor mapping. Neuroimage. 2016 Jun 27
- Hansen HD, Herth MM, Ettrup A, Lehel S, Kristensen J, Knudsen GM. Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors. J Nucl Med. 2014 Apr;55(4):640-6