Technical Staff

Contact

Lars Hansen
Position:
Senior scientist, Molecular Biology
Dept. Neurology and Neurobiology Research Unit,
Copenhagen University Hospital, Rigshospitalet,
Building 8057,
Blegdamsvej 9, DK-2100 Copenhagen, Denmark

Curriculum vitae

Scientific interests:

 Human genetics, inherited disorders, gene regulation, NGS and NGS data analyses, genomics, transcriptomics, neurologic conditions caused by genetic variation.

 

Biography: 

2021 -

Neurobiology Research Unit, Rigshospitalet

2013 - 2020  

Senior scientist, Copenhagen Center for Glycomics, ICMM, Copenhagen University

2000 -2013   

Research scientist, ICMM (Wilhelm Johannsen Centre), Copenhagen University

 

Publications:

Selected publications

  • Zilmer M, Edmondson AC, Khetarpal SA, Alesi V, Zaki MS, Rostasy K, Madsen CG, Lepri FR, Sinibaldi L, Cusmai R, Novelli A, Issa MY, Fenger CD, Abou Jamra R, Reutter H, Briuglia S, Agolini E, Hansen L, Petäjä-Repo UE, Hintze J, Raymond KM, Liedtke K, Stanley V, Musaev D, Gleeson JG, Vitali C, O'Brien WT, Gardella E, Rubboli G, Rader DJ, Schjoldager KT, Møller RS. (2020) Novel congenital disorder of O-linked glycosylation caused by GALNT2 loss of function. Brain. 143:1114-1126. doi: 10.1093/brain/awaa063
  • Farooq M, Lindbæk L, Krogh N, Doganli C, Keller C, Mönnich M, Gonçalves AB, Sakthivel S, Mang Y, Fatima A, Andersen VS, Hussain MS, Eiberg H, Hansen L, Kjaer KW, Gopalakrishnan J, Pedersen LB, Møllgård K, Nielsen H, Baig SM, Tommerup N, Christensen ST, Larsen LA. (2020). RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis. Nat Commun. 11:5816. doi: 10.1038/s41467-020-19658-0
  • Hansen L, Husein DM, Gericke B, Hansen T, Pedersen O, Tambe MA, Freeze HH, Naim HY, Henrissat B, Wandall HH, Clausen H, Bennett EP. (2020). A Mutation Map for Human Glycoside Hydrolase Genes. Glycobiology 30:500-515. Doi: 10.1093/glycob/cwaa010
  • Narimatsu Y, Joshi H, Nason R, Van Coillie J, Karlsson R, Sun L, Ye Z, Chen Y, Schjoldager KT, Steentoft C, Furukawa S, Bensing BA, Sullam PM, Thompson AJ, Paulson JC, Bull C, Adema GJ, Mandel U, Hansen L, Bennett EP, Varki A, Vakhrushev SY, Yang Z, Clausen H. (2019). An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells. Mol Cell 75: 1-14. DOI: 10.1016/j.molcel.2019.05.017
  • Joshi HJ, Hansen L, Narimatsu Y, Freeze HH, Henrissat B, Bennett EP, Wandall HH, Clausen H, Schjoldager KT. (2018): Glycosyltransferase Genes That Cause Monogenic Congenital Disorders of Glycosylation Are Distinct From Glycosyltransferase Genes Associated with Complex Diseases. Glycobiology, 28:284-294. DOI: 10.1093/glycob/cwy015. PMID: 29579191
  • Pinto R, Hansen L, Hintze J, Almeida R, Larsen S, Coskin M, Davidsen J, Mitchelmore C, David L, Troelsen JT, Bennett EP (2017). Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression. Nucleic Acids Res. 45:e123
  • Hansen L, Lind-Thomsen A, Joshi HJ, Pedersen NB, Have CT, Kong Y, Wang S, Sparso T, Grarup N, Vester-Christensen MB, Schjoldager K, Freeze HH, Hansen T, Pedersen O, Henrissat B, Mandel U, Clausen H, Wandall HH, Bennett EP. (2015) A glycogene mutation map for discovery of diseases of glycosylation. Glycobiology 25:211-24. DOI: 10.1093/glycob/cwu104. PMID: 25267602