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Pontus Plavén-Sigray

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Pontus Plavén-Sigray
Position:
Senior Researcher
Dept. Neurology and Neurobiology Research Unit,
Copenhagen University Hospital, Rigshospitalet,
Building 8057,
Blegdamsvej 9, DK-2100 Copenhagen, Denmark
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3545 6718

Curriculum vitae

Scientific interests:

Data analysis and Biostatistics

 

Biography:

2024 -

Senior Researcher at the Neurobiology Research Unit

2019 -   

Junior Faculty Member at the Neurobiology Research Unit

2018 - 2019

Post Doc at the Cervenka Lab, Center for Psychiatry Research, Karolinska Institutet. 

2013 - 2018

PhD student at the PET-group, Center for Psychiatry Research, Karolinska Institutet. The PhD focused on pharmacokinetic and
statistical modelling of neuroimaging data as well as investigation of in vivo neuroinflammation in patients with psychosis and
schizophrenia.

2012 - 2013

Research assistant at the PET-group, Center for Psychiatry Research, Karolinska Institutet. The work focused on research around
the involvement of the dopamine system in personality and personality disorders.  

2009 - 2011

Research assistant at the Section of Psychology, Department of Clinical Neuroscience Karolinska Institutet. The work focused on
psychometric and statistical modelling as well as teaching psychometric theory at the bachelor program for psychology at
Karolinska Institutet.

 

Publications:

Research articles

 

  1. Plavén-Sigray P, Gustavsson P, Farde L, Borg J, Stenkrona P, Nyberg L, Bäckman L, & Cervenka S (2014). Dopamine D1 receptor availability is related to social behavior: A positron emission tomography study. NeuroImage, 102, 590-595.

 

  1. Plavén-Sigray P, Hedman E, Victorsson P, Matheson GJ, Forsberg A, Djurfeldt D, Rück C, Halldin C, Lindefors N, & Cervenka S (2017). Extrastriatal dopamine D2-receptor availability in social anxiety disorder. European Neuropsychopharmacology, 27, 462–469.

 

  1. Collste K, Plavén-Sigray P, Fatouros-Bergman H, Victorsson P, Schain M, Forsberg A, Amini N, Aeinehband S, Karolinska Schizophrenia Project (KaSP) consortium, Erhardt S, Halldin C, Flyckt L, Farde L, & Cervenka S (2017). Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [11C]PBR28. Molecular Psychiatry, 22, 850-856.

 

  1. Matheson GJ, Plavén-Sigray P, Forsberg A, Varrone A, Farde L, & Cervenka S (2017). Assessment of simplified ratio-based approaches for quantification of PET [11C]PBR28 data. EJNMMI Research, 7.

 

  1. Plavén-Sigray P*, Matheson GJ*, Schiffler BC*, & Thompson WH (2017). The readability of scientific texts is decreasing over time. eLife, 6, e27725 *Authors contributed equally

 

  1. Matheson GJ, Stenkrona P, Cselényi Z, Plavén-Sigray P, Halldin C, & Farde L. (2017) Reliability of volumetric and surface-based normalisation and smoothing techniques for PET analysis of the cortex: A test-retest analysis using [11C]SCH-23390. Neuroimage, 155, 344–353.

 

  1. Plavén-Sigray P, Matheson GJ, Gustavsson P, Stenkrona P, Halldin C, Farde L, & Cervenka S (2018). Is dopamine D1 receptor availability related to social behavior? A positron emission tomography replication study. PLoS One, 13, e0193770.

 

  1. Plavén-Sigray P, Matheson GJ, Collste K, Ashok AH, Coughlin JM, Howes OD, Mizrahi R, Pomper MG, Rusjan P, Veronese M, Wang Y, & Cervenka S (2018). Positron Emission Tomography Studies of the Glial Cell Marker Translocator Protein in Patients With Psychosis: A Meta-analysis Using Individual Participant Data. Biological Psychiatry, 84, 433-442.

 

  1. Thompson WH, Richter CG, Plavén-Sigray P, & Fransson P (2018). Simulations to benchmark time-varying connectivity methods for fMRI. PLoS computational biology, 14, e1006196.

 

  1. Stenkrona P, Matheson GJ, Cervenka S, Plavén-Sigray P, Halldin H, & Farde L (2018). [11C]SCH23390 binding to the D1-dopamine receptor in the human brain - a comparison of manual and automated methods for image analysis. EJNMMI Research, 8.

 

  1. Plavén-Sigray P, Matheson GJ, Cselényi Z, Jučaite A, Farde L, & Cervenka S (2018). Test-retest reliability and convergent validity of (R)-[11C] PK11195 outcome measures without arterial input function. EJNMMI Research, 8, 102.

 

  1. Caravaggio F, Plavén-Sigray P, Matheson GJ, Plitman E, Chakravarty M, Graff-Guerrero A, Cervenka S (2018): Trait impulsivity is not related to post-commissural putamen volumes: A replication study in healthy men. PLoS One. 13, e0209584.

 

  1. Plavén-Sigray P, Schain M, Zanderigo F, Karolinska [11C]PBR28 study group, Rabiner I, Gunn R, Ogden T, & Cervenka S (2018). Accuracy and reliability of [11C]PBR28 specific binding estimated without the use of a reference region. NeuroImage, 188, 102-110.

 

  1. Tuisku J, Plavén-Sigray P, Gaiser EC, Airas L, Al-Abdulrasul H, Brück H, Carson RE, Chen MK, Cosgrove KP, Ekblad L, Esterlis I, Farde L,Forsberg A, Halldin C, Helin S, Kosek E, Lekander M, Lindgren N, Marjamäki P, Rissanen E, Sucksdorff M, Varrone A, HRRT [11C]PBR28 study group, Rinne J, Matuskey D, Cervenka S (2019). Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [11C]PBR28 HRRT PET study. EJNMMI, 46, 2329-2338.

 

  1. Matheson GJ, Plavén-Sigray P, Louzolo A, Borg J, Farde L, Petrovic P, & Cervenka S (2018). Dopamine D1 receptor availability is not associated with delusional ideation measures of psychosis proneness. Manuscript on bioRxiv, 321646.

 

 

Reviews, commentaries and letters to the editor

 

  1. Farde L, Plavén-Sigray P, Borg J, & Cervenka S (2018). Brain neuroreceptor density and personality traits: towards dimensional biomarkers for psychiatric disorders. Phil Trans R Soc B, 373.

 

  1. Plavén-Sigray P & Cervenka S (2019). Meta-analytic studies of the glial cell marker TSPO in psychosis – a question of apples and pears: A commentary on “Neuroinflammation in schizophrenia: metaanalysis of in-vivo microglial imaging” by Marques et al. Psychological Medicine, 49, 1624-1628.

 

  1. Matheson G*, Plavén-Sigray P*, Tuisku J, Rinne J, Matuskey D, Cervenka S (2019). Clinical Brain PET Research Must Embrace Multi-Centre Collaboration and Data Sharing or Risk its Demise. EJNMMI, Accepted. *Authors contributed equally



Awards:

2017  Swedish Society of Medical Research’s grant for a research visit abroad.

2016  NeuroReceptor Mapping conference young investigator award

2014  Psykiatrifonden’s research award.