Non-invasive Magnetic Resonance diagnostics of hydrocephalus or increased intracranial pressure (UFMR-project)
The overall aim of this project is to investigate whether brain pulsations, as measured by ultra-fast magnetic resonance imaging (UFMR), are influenced by dynamic and chronic changes in intracranial pressure. If this is the case, the UFMR-method could be a valuable non-invasive tool for diagnosing and monitoring conditions with increased intracranial pressure (ICP), such as Normal Pressure Hydrocephalus (iNPH) and Idiopathic Intracranial Hypertension (IIH).
The project is a hospital-based prospective, observational cohort study, in which we will assess UFMR-detected brain pulsations in patients suffering from IIH and iNPH.
We will include patients who, on clinical indication and as part of their existing clinical course of treatment, undergo MR imaging and are
1) referred to a diagnostic tap test (iNPH)
2) diagnosed with a lumbar opening pressure above 250 mmCSF (IIH)
3) referred to an implantation of an intracranial ICP device and shunt operation (iNPH)