Contact person: Jens D. Mikkelsen
At the Experimental Neurobiology Laboratory located on the 6th floor in the North Wing building, we carry out experimental research on brain tissues obtained from patients. We also work with tissues from animal models (experimental and transgenic), cell cultures, as well as human material. Work on experimental animal models is performed in building 93 and in collaboration with our partners. These partners mainly include clinical groups in the Neurology center, but also academic and industrial research teams around the world.
Some of the techniques we are currently working with include: immunohistochemistry, microscopy, autoradiography, image analysis, receptor binding studies, RT-PCR, Western blot, and ELISA.
The Experimental Neurobiology Laboratory aims to create a two-way bridge between basal experimental research and the clinical projects carried out at NRU. Weekly meetings, translational research (PhD) projects and close interaction between the experimental and clinical researchers create a dynamic forum where ideas that range from the cells and circuits to cognitive testing and neuroimaging are discussed.
Examples of recent publications:
- Mikkelsen JD, Kaad S, Aripaka SS, Finsen B. Synaptic vesicle glycoprotein 2A (SV2A) levels in the cerebral cortex in patients with Alzheimer's disease: a radioligand binding study in postmortem brains. Neurobiol Aging. 2023 Sep;129:50-57
- Mikkelsen JD, Aripaka SS, Kaad S, Pazarlar BA, Pinborg L, Finsen B, Varrone A, Bang-Andersen B, Bastlund JF. Characterization of the Novel P2X7 Receptor Radioligand [3H]JNJ-64413739 in Human Brain Tissue. ACS Chem Neurosci. 2023 Jan 4;14(1):111-118
- Aripaka SS, Bech-Azeddine R, Jørgensen LM, Mikkelsen JD. Transient receptor potential (TRP) channels mRNA transcripts in the lumbar intervertebral discs: biomarkers for inflammation, pain, disability, and clinical outcome. Mol Cell Biochem. 2023 Jan;478(1):121-130
- Mikkelsen JD, Aripaka SS, Bascuñana P, Bankstahl M, Bankstahl JP, Pazarlar BA. Spatio-Temporal Alterations in Synaptic Density During Epileptogenesis in the Rat Brain. Neuroscience. 2022 Sep 1;499:142-151
- Pazarlar BA, Aripaka SS, Petukhov V, Pinborg L, Khodosevich K, Mikkelsen JD. Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE). Mol Brain. 2022 May 16;15(1):45
- Pazarlar BA, Madsen CA, Oyar EÖ, Eğilmez CB, Mikkelsen JD. Temporal and spatial changes in synaptic vesicle glycoprotein 2A (SV2A) under kainic acid induced epileptogenesis: An autoradiographic study. Epilepsy Res. 2022 Jul;183:106926
- Aripaka SS, Bech-Azeddine R, Jørgensen LM, Mikkelsen JD. The expression of metalloproteinases in the lumbar disc correlates strongly with Pfirrmann MRI grades in lumbar spinal fusion patients. Brain Spine. 2022 Feb 5;2:100872