New MR-scanner for NRU

NRU has received 10 mio DKK from the KFJ Foundation to acquire a brain-dedicated research MR-scanner to be placed in the new North Wing. We are very grateful for their generous gift and look forward to start to use it.

More funding for NRU

Congratulations to Vibe Frøkjær for receiving DKK 300.000 from Desirée & Niels Ydes Fond for the project 'Neuroendocrine mechanisms in perinatal depression; the role of sex steroids and serotonin brain dynamics' and to Vibe Frøkjær/Gitte Moos for receiving a scholarship grant from the Danish Society for Psychiatry for Daniel Burmester (DKK 80.000) to perform the project 'Human brain serotonin 2A receptor levels and mood states'.

Scholarship grant from FSS to NRU

Gitte Moos and Sebastian Holst have received a scholarship grant (103.000) from FSS for the project: 'Effects of sleep deprivation and adrenergic inhibition on glymphatic flow in humans'.

Short project summary:
Roughly a third of our life is spent asleep, yet the function(s) of sleep remain poorly understood. Recently, a novel molecular role for sleep was described in rodents. The ‘glymphatic system’ is a sleep dependent macroscopic pathway in the brain, which facilitates clearance of interstitial waste products. So far, the glymphatic system has only been described in rodents. Here, effects of the human glymphatic system will be investigated in two ways. First, we will apply the novel
MR protocol MREG (ultra-fast magnetic resonance encephalography) in both awake and sleeping subjects to show the existence of human glymphatic flow. Secondly, we will interfere with glymphatic flow by administering the adrenergic antagonist carvedilol in a placebo controlled, crossover manner immediately before MREG imaging. Thereby we will test the effects of enhanced glymphatic activity on sleep and wakefulness. Together the study will provide the first evidence for a sleep dependent human glymphatic system.

New funding for NRU from the Danish Council for Independent Research

Congratulations to Vibe Frøkjær and Lars Pinborg, each for receiving 1.8 mio for the projects 'The role of sex steroids and serotonin brain dynamics in perinatal mental health' and 'Severe epilepsy - a new era in the presurgical evaluation by ultra high field MR at 7 Tesla', granted by the Danish Council for Independent Research - Medical Sciences.

Short Danish summaries:
Depression er en folkesygdom med enorme personlige og samfundsmæssige omkostninger. Sygdommen rammer dobbelt så mange kvinder som mænd, og der er et påtrængende behov for at målrette og optimere forebyggelse og behandling. Risikoen for at udvikle depression er markant forhøjet hos kvinder, når de i forbindelse med graviditet og fødsel gennemgår store kønshormonelle svingninger. Vi ved ikke, hvorfor nogle kvinder er i særlig risiko for fødselsdepression, men nye studier peger på, at østrogenfølsomhed spiller en afgørende rolle. Vi har tidligere påvist, at farmakologisk udløste ændringer i kvindeligt kønshormon kan udløse milde depressive symptomer hos ellers raske kvinder. Symptomerne er koblet både til østrogenudsving og til en stigning i hjernens serotonin transporter (SERT) niveau, der sænker hjernens signalstof serotonin. Vi ved dog ikke, om graviditet er forbundet med en stigning af SERT, som i en overgangsfase vil sænke hjernens serotoninniveau. Vi vil i dette projekt undersøge kvinder under graviditet, ved fødslen og i det tidlige efterfødselsforløb for at afdække samspillet mellem kønshormoner, serotonin og depression. Vi vil også teste, om en biomarkør kandidat (gentranskriptionsprofil) forudsiger fødselsdepression og serotonerg tonus lige så godt som hjerneskan 4 uger efter fødslen. Vores mål er at finde biomarkører, der kan identificere kvinder i højrisiko for fødselsdepression for derved at kunne målrette en individualiseret forebyggelse.
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Ultra højfelts magnetisk resonans (MR) skanning ved 7 tesla (7T MR) vil blive anvendt til udforskning af svær epilepsi, idet 7T MR giver flere og mere detaljerede oplysninger om strukturelle og biokemiske forhold i hjernen end den konventionelle MR skanning ved 3T. Vores arbejdshypotese er, at 7T MR skanning vil give ny viden om epilepsisygdommens natur, om strukturelle og biokemiske abnormiteter samt om epileptiske netværk. De opnåede resultater forventes at få direkte betydning for den preoperative udredning forud for epilepsikirurgiske indgreb. Placeringen af intrakranielle elektroder anbragt på og i hjernen vil kunne forgå mere præcist og i nogle tilfælde helt kunne undgås. Den forbedrede preoperative udredning vil føre til bedre kirurgiske resultater, dvs. flere patienter vil kunne tilbydes operation, og flere vil kunne gøres anfaldsfri. Vi har allerede foreløbige resultater, der viser forbedret diagnostisk værdi af 7T MR, hvilket understøtter arbejdshypotesen.

NRU annual report 2016

The 2016 NRU annual report has been published and is available for download here.

Three new grants for NRU

Vincent Beliveau has been granted a travel stipend from the Lundbeck Foundation for his PhD stay abroad in Saclay, France (DKK 12,000). Gitte Moos has received 500,000 from the Lundbeck Foundation for running costs in connection with the project 'In vivo imaging of cerebral epigenetic changes following 5-HT2AR modulation' and finally, Gitte has also received 900,000 from Rigshospitalet's Research Council for the project 'The effect of sleep deprivation and adrenergic inhibition on cognitive performance and cerebral water diffusion'.

NRU in the media about the mysterious epilepsy

Ass. Prof Lars Pinborg and Prof Gitte Moos Knudsen participated in the third episode of DR K’s documentary “Død og pine: Lægevidenskabens Historie” which was about the history of medicine and the development within epilepsy treatment and brain imaging. The episode was broadcasted March 1, 2017, but can be seen here: https://www.dr.dk/tv/se/doed-og-pine/-/doed-og-pine-laegevidenskabens-historie-3#!

PhD student Mette Thrane Foged has in a small video clip explained about new studies with a recently developed and refined EEG cap, which with an unprecedented precision can show where in the human brain the epilepsy occurs. Information which is highly relevant for doctors when deciding whether or not a given epilepsy patient should be offered a surgical procedure. The video clip is available here: http://region-hovedstaden-ekstern.23video.com/tankehat-ny-eeg-haette-kan-forbedre

Grant from Brd. Hartmanns Fond

Congratulations to Gitte for receiving 100.000 DKK from Brødrene Hartmanns Fond for the NeuroPharm (NP2) project "Neurobiologiske effekter af 5-HT2AR modulering". The grant will finance a new fluorescence detector for NRU which in this project will be used for measuring ketanserin levels in plasma. Below is a Danish summary of the granted application.

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Welcome to Kevser og Sidra

NRU welcomes Kevser and Sidra, both from Medicine & Technology. They will be working on their BSc project "Optimization of motion correction of frames in dynamic PET molecular imaging studies".

Kevser                                Sidra

        

Marie Curie grant to NRU

We are happy to announce that Gitte Moos has been granted a two-year Marie Sklodowska-Curie Individual Fellowship (MSCA-IF-2016) for post doc Brice Ozenne and the proposal "NEUROMODEL - Statistical Modelling for relating multimodal neuroimaging to clinical outcomes in order to predict patient response to depression therapy".

The EU grant is worth 200.194 EUR and it enables Brice, who for the last 15 months has been working in a 50/50 post doc position shared by NRU and Section of Biostatistics on KU, to be fully employed at NRU for the next 24 months. We are looking forward to hosting Brice's project here at NRU!

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